Purpose To develop an experimental protocol to calculate the precision and accuracy of
fractional anisotropy (FA), mean diffusivity (MD), and the orientation of the principal eigenvector (…

Diffusion tensor imaging (DTI) is used to study tissue composition and architecture in vivo.
To increase the signal to noise ratio (SNR) of DTI contrasts, studies typically use more than …

The mechanisms underlying the pathogenesis of multiple sclerosis induce the changes that
underpin relapse-associated and progressive disability. Disease mechanisms can be …

Modern MRI image processing methods have yielded quantitative, morphometric, functional,
and structural assessments of the human brain. These analyses typically exploit carefully …

Magnetization transfer (MT) imaging provides a unique method of tissue characterization by
capitalizing on the interaction between solid‐like tissue components and bulk water. We …

Chemical exchange saturation transfer (CEST)‐derived, pH‐weighted, amide proton
transfer (APT) MRI has shown promise in animal studies for the prediction of infarction risk in …

Chemical exchange saturation transfer imaging can generate contrast that is sensitive to
amide protons associated with proteins and peptides (termed amide proton transfer, APT). In …

Quantitative spinal cord (SC) magnetic resonance imaging (MRI) presents many challenges,
including a lack of standardized imaging protocols. Here we present a prospectively …

Objective To determine whether damage to the optic radiation (OR) in multiple sclerosis (MS)
is associated with optic nerve injury and visual dysfunction. Design Case-control study. …

Purpose To investigate the physical mechanisms associated with the contrast observed in
neuromelanin MRI. Methods Phantoms having different concentrations of synthetic melanins …