User profiles for Seung-Hyun Oh
Seung Hyun OhCollege of Veterinary Medicine, Seoul National University Verified email at snu.ac.kr Cited by 5180 |
Structural basis for depletion of heat shock protein 90 client proteins by deguelin
Background The molecular chaperone heat shock protein 90 (Hsp90) participates in preserving
the expression and activity of various oncoproteins, including hypoxia-inducible factor …
the expression and activity of various oncoproteins, including hypoxia-inducible factor …
Hepatitis B virus X protein enhances transcriptional activity of hypoxia-inducible factor-1α through activation of mitogen-activated protein kinase pathway
Hepatitis B virus X protein (HBx) of the hepatitis B virus was strongly implicated in angiogenesis
and metastasis during hepatocarcinogenesis. Here, we explored the possibility of cross-…
and metastasis during hepatocarcinogenesis. Here, we explored the possibility of cross-…
Chemopreventive effects of deguelin, a novel Akt inhibitor, on tobacco-induced lung tumorigenesis
Tobacco carcinogens induce Akt activation and lung carcinogenesis. We previously
demonstrated that deguelin, a natural plant product, specifically inhibits the proliferation of …
demonstrated that deguelin, a natural plant product, specifically inhibits the proliferation of …
DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progression
…, CH Lee, SH Oh, YS Song, HS Kim, YH Oh… - Nature …, 2015 - nature.com
DOT1L has emerged as an anticancer target for MLL-associated leukaemias; however, its
functional role in solid tumours is largely unknown. Here we identify that DOT1L cooperates …
functional role in solid tumours is largely unknown. Here we identify that DOT1L cooperates …
Targeting heat shock protein 90 overrides the resistance of lung cancer cells by blocking radiation-induced stabilization of hypoxia-inducible factor-1α
Hypoxia-inducible factor-1 (HIF-1) has been suggested to play a major role in tumor
radioresistance. However, the mechanisms through which irradiation regulates HIF-1α expression …
radioresistance. However, the mechanisms through which irradiation regulates HIF-1α expression …
Ergosterol peroxide from Chaga mushroom (Inonotus obliquus) exhibits anti-cancer activity by down-regulation of the β-catenin pathway in colorectal cancer
Aim of the study In this study, we examined the effect of different fractions and components
of Chaga mushroom (Inonotus Obliquus) on viability and apoptosis of colon cancer cells. …
of Chaga mushroom (Inonotus Obliquus) on viability and apoptosis of colon cancer cells. …
Identification of novel antiangiogenic anticancer activities of deguelin targeting hypoxia‐inducible factor‐1 alpha
Hypoxia‐inducible factor 1 (HIF‐1) plays an essential role in tumor angiogenesis and growth
by regulating the transcription of several genes in response to hypoxic stress and changes …
by regulating the transcription of several genes in response to hypoxic stress and changes …
Gut microbiota of the young ameliorates physical fitness of the aged in mice
… In the same manner, feces from old or very old mice (O or VO) were respectively given to
12- or 25-month-old groups, resulting in Old O or vOld VO mice. All the recipient mice were …
12- or 25-month-old groups, resulting in Old O or vOld VO mice. All the recipient mice were …
Regulation of the chondrocyte phenotype by β-catenin
β-Catenin regulates important biological processes, including embryonic development and
tumorigenesis. We have investigated the role ofβ-catenin in the regulation of the chondrocyte …
tumorigenesis. We have investigated the role ofβ-catenin in the regulation of the chondrocyte …
Cancer-associated splicing variant of tumor suppressor AIMP2/p38: pathological implication in tumorigenesis
Although ARS-interacting multifunctional protein 2 (AIMP2, also named as MSC p38) was
first found as a component for a macromolecular tRNA synthetase complex, it was recently …
first found as a component for a macromolecular tRNA synthetase complex, it was recently …