Background Brain tumors are the most common solid tumors and the leading cause of
cancer-related death among all childhood cancers. Tumor segmentation is essential in surgical …

Tumor-associated macrophages (TAMs) play an important role in tumor immunity and comprise
of subsets that have distinct phenotype, function, and ontology. Transcriptomic analyses …

Introduction Despite advancements in molecular and histopathologic characterization of
pediatric low-grade gliomas (pLGGs), there remains significant phenotypic heterogeneity …

The current era of advanced computing has allowed for the development and implementation
of the field of radiomics. In pediatric neuro-oncology, radiomics has been applied in …

Background: Brain tumors are the most common solid tumors in children, and high-grade
brain tumors are the leading cause of cancer-related death among all childhood cancers. …

Medulloblastoma is a highly heterogeneous pediatric brain tumor with five molecular
subtypes, Sonic Hedgehog TP53-mutant, Sonic Hedgehog TP53-wildtype, WNT, Group 3, and …

OBJECTIVE The clinical behavior of meningiomas is not entirely captured by its designated
WHO grade, therefore other factors must be elucidated that portend increased tumor …

Pediatric brain and spinal cancers remain the leading cause of cancer-related death in
children. Advancements in clinical decision-support in pediatric neuro-oncology utilizing the …

In pediatric low-grade gliomas (pLGG), prognosis and responses to treatments are heterogeneous.
This heterogeneity may be explained by the differences in molecular composition of …

Recent studies have shown preliminary evidence for differentiation of the tumor microenvironment
(TME) and immune landscape between molecularly-defined medulloblastoma (MB) …