In infections, microbial components provide signals that alert the immune system to danger
and promote the generation of immunity 1 , 2 . In the absence of such signals, there is often …

We describe the landscape of somatic genomic alterations based on multidimensional and
comprehensive characterization of more than 500 glioblastoma tumors (GBMs). We identify …

… Yan Shi is with the State Key Laboratory of Networking and Switching Technology, Beijing
… Yan Shi (shiyan@bupt.edu.cn) received her Ph.D. degree from Beijing University of Posts …

Multiple sclerosis (MS) is a devastating neuroinflammatory disorder of the central nervous
system (CNS) in which T cells that are reactive with major components of myelin sheaths have …

Amyloid-beta peptide is central to the pathology of Alzheimer's disease, because it is
neurotoxic—directly by inducing oxidant stress, and indirectly by activating microglia. A specific cell-…

Paired helical filament (PHF) tau is the principal component of neurofibriliary tangles, a
characteristic feature of the neurodegenerative pathology in Alzheimer's disease (AD). Post-…

AGEs Tumor biology Amphoterin albumin prepared in vitro (7). Its extracellular domain
consists of three immunoglobulin-like regions, one “V”-type followed by two “C”-type (8). RAGE …

An improved understanding of stem-cell and regenerative biology, as well as a better control
of stem-cell fate, is likely to produce treatments for many devastating diseases and injuries. …

Receptor for advanced glycation end products (RAGE) is a multiligand member of the
immunoglobulin superfamily of cell surface molecules whose repertoire of ligands includes …

Recent breakthroughs in using viral transduction of a few genes for the reprogramming of both
mouse and human somatic cells into induced pluripotent stem (iPS) cells have opened up …