Lysine‐specific demethylase 5A (KDM5A) has recently become a promising target for epigenetic
therapy. In this study, we designed and synthesized metal complexes bearing ligands …

Twenty six peroxides belonging to bridged 1,2,4,5‐tetraoxanes, bridged 1,2,4‐trioxolanes (ozonides),
and tricyclic monoperoxides were evaluated for their in vitro antimalarial activity …

Background and Purpose Celastrol exhibits anti‐arthritic effects in rheumatoid arthritis (RA),
but the role of celastrol‐mediated Ca 2+ mobilization in treatment of RA remains undefined. …

Drug resistance hinder most cancer chemotherapies and leads to disease recurrence and
poor survival of patients. Resistance of cancer cells towards apoptosis is the major cause of …

Acute lung injury (ALI) is generally caused by severe respiratory infection and characterized
by overexuberant inflammatory responses and inefficient pathogens-containing, the two …

Four benzofuran-conjugated iridium(III) or rhodium (III)-based metal complexes are synthesized
to screen as an inhibitor of STAT3 activity in prostate cancer cells. All complexes show …

Recent studies have shown that short-chain fatty acids (SCFAs), primarily acetate, propionate
and butyrate, play a crucial role in the pathogenesis of cardiovascular disease. Whether …

Autophagy is a universal catabolic cellular process for quality control of cytoplasm and
maintenance of cellular homeostasis upon nutrient deprivation and environmental stimulus. It …

Resistance of cancer cells to chemotherapy is a significant clinical concern and mechanisms
regulating cell death in cancer therapy, including apoptosis, autophagy or necrosis, have …

Galectin-3 is a multi-functional protein and participates in mediating inflammatory reactions.
The pronounced overexpression of galectin-3 in prion-infected brain tissue prompted us to …