CD-HIT is a widely used program for clustering biological sequences to reduce sequence
redundancy and improve the performance of other sequence analyses. In response to the …

Motivation: Pair-wise residue-residue contacts in proteins can be predicted from both threading
templates and sequence-based machine learning. However, most structure modeling …

We developed LOMETS, a local threading meta-server, for quick and automated predictions
of protein tertiary structures and spatial constraints. Nine state-of-the-art threading programs …

Background Predicting 3-dimensional protein structures from amino-acid sequences is an
important unsolved problem in computational structural biology. The problem becomes …

Background The new field of metagenomics studies microorganism communities by culture-independent
sequencing. With the advances in next-generation sequencing techniques, …

The rapid advances of high-throughput sequencing technologies dramatically prompted
metagenomic studies of microbial communities that exist at various environments. Fundamental …

We develop a new threading algorithm MUSTER by extending the previous sequence
profile–profile alignment method, PPA. It combines various sequence and structure information …

Epilepsy is a frequent feature of neurodevelopmental disorders (NDDs), but little is known
about genetic differences between NDDs with and without epilepsy. We analyzed de novo …

Helminth parasites ensure their survival by regulating host immunity through mechanisms
that dampen inflammation. These properties have recently been exploited therapeutically to …

Helminth infection in pigs serves as an excellent model for the study of the interaction
between human malnutrition and parasitic infection and could have important implications in …