Small extracellular vesicles (sEVs) from mesenchymal stromal/stem cells (MSCs) are transiting
rapidly towards clinical applications. However, discrepancies and controversies about …

Importance There are limited efficacious treatments for Alzheimer disease. Objective To assess
efficacy and adverse events of donanemab, an antibody designed to clear brain amyloid …

Community‐based surveys were performed in seven rural areas in Japan to investigate the
prevalence of dementia and illnesses causing dementia. A total of 5431 elderly subjects …

Oligomeric forms of amyloid-β peptide (Aβ) are thought to play a pivotal role in the
pathogenesis of Alzheimer's disease (AD), but the mechanism involved is still unclear. Here, we …

Although hydrogen sulfide (H 2 S) is generally thought of in terms of a poisonous gas, it is
endogenously produced in the brain from cysteine by cystathionine β-synthase (CBS). H 2 S …

The present study used functional magnetic resonance to examine the cerebral activity pattern
associated with musical perception in musicians and non-musicians. Musicians showed …

The aim of this SPECT study was to determine the initial abnormality and longitudinal changes
in regional cerebral blood flow (rCBF) in early Alzheimer's disease (AD) using statistical …

We assessed the accuracy of voxel-based morphometry (VBM) using a three-dimensional
T1-weighted MRI in discriminating Alzheimer's disease (AD) in the very early stage of …

Mild cognitive impairment (MCI) comprises a heterogeneous group with a variety of clinical
outcomes and they are at risk for developing Alzheimer's disease (AD). The prediction of …

BACKGROUND AND PURPOSE: Whether Alzheimer disease (AD) represents exaggerated
aging rather than a disease is controversial. Data about the effects of normal aging on the …