Mitogen-Activated Protein Kinase Kinase Kinases (MAPKKKs) are important components of
MAPK cascades, which are universal signal transduction modules and play important role in …

Glioblastoma multiforme (GBM) is one of the most common and aggressive type of malignant
glioma with an average survival time of 12–18 mo. Despite the utilization of extensive …

Congenital heart disease (CHD) is one of the most prevalent neonatal congenital anomalies.
To catalog the putative candidate CHD risk genes, we collected 16,349 variants [single-…

The advent of long-read sequencing offers a new assessment method of detecting genomic
structural variation (SV) in numerous rare genetic diseases. For autism spectrum disorders (…

Neurodevelopmental disorders (NDDs) and congenital anomalies (CAs) are rare disorders
with complex etiology. In this study, we investigated the less understood genomic overlap of …

Understanding host cell heterogeneity is critical for unraveling disease mechanism. Utilizing
large-scale single-cell transcriptomics, we analyzed multiple tissue specimens from patients …

Background: Flexnerism, or “competency-based medical education,” advocates that formal
analytic reasoning, the kind of rational thinking fundamental to the basic sciences, especially …

Background: With the rapid integration of genetics into medicine, it has become evident that
practicing physicians as well as medical students and clinical researchers need to be …

Designing antagonists to anti-apoptotic proteins of Bcl-2 family has become an important
strategy in cancer chemotherapy. Using experimental techniques and computational methods, …

Generation of human induced pluripotent stem cells (iPSCs) through reprogramming was a
transformational change in the field of regenerative medicine that led to new possibilities for …