Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide
association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and …

Health disparities exist among minorities in the United States, with differences seen in disease
prevalence, mortality, and responses to medications. These differences are multifactorial …

Background Exome sequencing in hundreds of thousands of persons may enable the
identification of rare protein-coding genetic variants associated with protection from human …

Body fat distribution is a major, heritable risk factor for cardiometabolic disease, independent
of overall adiposity. Using exome-sequencing in 618,375 individuals (including 160,058 …

Race and ancestry have long been associated with differential risk and outcomes to disease
as well as responses to medications. These differences in drug response are multifactorial …

OBJECTIVES:: Tandem mass spectrometry is a major technological advance in the
screening for inborn errors of metabolism. It has the advantage of sensitive and simultaneous …

Heart failure is a leading cause of morbidity and mortality 1 , 2 . Elevated intracardiac pressures
and myocyte stretch in heart failure trigger the release of counter-regulatory natriuretic …

African Americans (AAs) are disproportionately affected by metabolic diseases and adverse
drug events, with limited publicly available genomic and transcriptomic data to advance the …

Importance Major warfarin-related bleeding occurs more frequently in African Americans than
in other populations. Identification of potential genetic factors related to this adverse event …

Increased blood levels of low-density lipoprotein cholesterol (LDL-C) and fibrinogen are
independent risk factors for cardiovascular disease. We identified associations between an …