User profiles for Tian Ge
Tian GeMassachusetts General Hospital, Harvard Medical School Verified email at mgh.harvard.edu Cited by 13790 |
Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders
Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these …
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these …
Principles and methods for transferring polygenic risk scores across global populations
Polygenic risk scores (PRSs) summarize the genetic predisposition of a complex human
trait or disease and may become a valuable tool for advancing precision medicine. However, …
trait or disease and may become a valuable tool for advancing precision medicine. However, …
Genetics of the connectome
Connectome genetics attempts to discover how genetic factors affect brain connectivity.
Here we review a variety of genetic analysis methods—such as genome-wide association …
Here we review a variety of genetic analysis methods—such as genome-wide association …
Immobilization technology: a sustainable solution for biofuel cell design
Biofuel cells provide a versatile means to generate electrical power from environmentally
friendly biomass or biofuels. Immobilization technology has played an important role in the …
friendly biomass or biofuels. Immobilization technology has played an important role in the …
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
Schizophrenia has a heritability of 60–80% 1 , much of which is attributable to common risk
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …
Polygenic prediction via Bayesian regression and continuous shrinkage priors
Polygenic risk scores (PRS) have shown promise in predicting human complex traits and
diseases. Here, we present PRS-CS, a polygenic prediction method that infers posterior effect …
diseases. Here, we present PRS-CS, a polygenic prediction method that infers posterior effect …
Effects of potassium levels on plant growth, accumulation and distribution of carbon, and nitrate metabolism in apple dwarf rootstock seedlings
…, F Wang, J Sha, Q Chen, G Tian, Z Zhu, S Ge… - Frontiers in Plant …, 2020 - frontiersin.org
Nitrogen (N) is one of the most required mineral elements for plant growth, and potassium (K)
plays a vital role in nitrogen metabolism, both elements being widely applied as fertilizers …
plays a vital role in nitrogen metabolism, both elements being widely applied as fertilizers …
The genetic architecture of the human cerebral cortex
…, SF Foley, JM Ford, M Fukunaga, ME Garrett, T Ge… - Science, 2020 - science.org
INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities.
Variations in human cortical surface area and thickness are associated with neurological, …
Variations in human cortical surface area and thickness are associated with neurological, …
Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease
Biobanks facilitate genome-wide association studies (GWASs), which have mapped genomic
loci across a range of human diseases and traits. However, most biobanks are primarily …
loci across a range of human diseases and traits. However, most biobanks are primarily …
Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries
Inflammatory bowel diseases (IBDs) are chronic disorders of the gastrointestinal tract with
the following two subtypes: Crohn’s disease (CD) and ulcerative colitis (UC). To date, most …
the following two subtypes: Crohn’s disease (CD) and ulcerative colitis (UC). To date, most …