The expression of matrix metalloproteinase-2 (MMP-2) has been linked with tumor invasion,
angiogenesis, and metastasis. However, the molecular basis for MMP-2 overexpression in …

Brain metastasis is a major cause of morbidity and mortality in patients with melanoma. The
molecular changes that lead to brain metastasis remain poorly understood. In this study, we …

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer
worldwide. To explore the genetic origins of this cancer, we used whole-exome sequencing and …

The survival of patients with oral squamous cell carcinoma (OSCC) has not changed
significantly in several decades, leading clinicians and investigators to search for promising …

The transcription factor Forkhead box M1 (FoxM1) is overexpressed in malignant glioma.
However, the functional importance of this factor in human glioma is not known. In the present …

Many mutant p53 proteins (mutp53s) exert oncogenic gain-of-function (GOF) properties, but
the mechanisms mediating these functions remain poorly defined. We show here that GOF …

Nanotechnology profoundly affects the advancement of medicine. Limitations in diagnosing
and treating cancer and chronic diseases promote the growth of nanomedicine. However, …

Angiogenesis is a key pathologic feature of glioblastoma, which is the most common and
most lethal primary brain tumor in adults. The degree of angiogenesis has been shown to be …

To determine the key aroma compounds in Chinese rice wine (CRW), four types of CRW (YH,
JF, SN, and XX) were analyzed by gas chromatography–mass spectrometry (GC–MS), gas …

Pancreatic cancer lacks effective therapy. Here, we reported two metastatic pancreatic cancer
patients administrated with Claudin 18.2 (CLDN 18.2) CART therapy after the failure of …