Short-chain fatty acid metabolism and multiple effects on cardiovascular diseases

T Hu, Q Wu, Q Yao, K Jiang, J Yu, Q Tang - Ageing Research Reviews, 2022 - Elsevier
Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide, and fatty
acid metabolism has been well studied. Short-chain fatty acids (SCFAs) have been less …

S100A8/A9 in myocardial infarction: a promising biomarker and therapeutic target

ZL Cai, Q Xie, T Hu, Q Yao, J Zhao, Q Wu… - Frontiers in cell and …, 2020 - frontiersin.org
Myocardial infarction (MI), the main cause of cardiovascular-related deaths worldwide, has
long been a hot topic because of its threat to public health. S100A8/A9 has recently attracted …

A Novel Postbiotic From Lactobacillus rhamnosus GG With a Beneficial Effect on Intestinal Barrier Function

J Gao, Y Li, Y Wan, T Hu, L Liu, S Yang… - Frontiers in …, 2019 - frontiersin.org
It has long been known that probiotics can be used to maintain intestinal homeostasis and
treat a number of gastrointestinal disorders, but the underlying mechanism has remained …

PRDM16 exerts critical role in myocardial metabolism and energetics in type 2 diabetes induced cardiomyopathy

T Hu, Q Wu, Q Yao, J Yu, K Jiang, Y Wan, Q Tang - Metabolism, 2023 - Elsevier
Background The prevalence of type 2 diabetes mellitus (T2DM) has increased over the past
decades. Diabetic cardiomyopathy (DCM) is the leading cause of death in T2DM patients, …

[HTML][HTML] Dapagliflozin protects against chronic heart failure in mice by inhibiting macrophage-mediated inflammation, independent of SGLT2

Q Wu, Q Yao, T Hu, J Yu, K Jiang, Y Wan, Q Tang - Cell Reports Medicine, 2023 - cell.com
The specific mechanism of sodium-glucose cotransporter 2 (SGLT2) inhibitor in heart failure
(HF) needs to be elucidated. In this study, we use SGLT2-global-knockout (KO) mice to …

NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology

…, Z Gong, L Liu, H Zhang, Y Li, S Yang, T Hu… - Cellular & molecular …, 2020 - nature.com
Tongtong Hu

Cathepsin B deteriorates diabetic cardiomyopathy induced by streptozotocin via promoting NLRP3-mediated pyroptosis

C Liu, Q Yao, T Hu, Z Cai, Q Xie, J Zhao, Y Yuan… - … Therapy Nucleic Acids, 2022 - cell.com
Cathepsin B (CTSB), a member of lysosomal cathepsin, is involved in cell autophagy and
apoptosis. We previously reported that CTSB increased cardiomyocyte apoptosis in mice heart …

Andrographolide protects against adverse cardiac remodeling after myocardial infarction through enhancing Nrf2 signaling pathway

…, C Liu, M Duan, Z Cai, Q Xie, T Hu… - International …, 2020 - pmc.ncbi.nlm.nih.gov
Adverse cardiac remodeling after myocardial infarction (MI) is associated with extremely high
mortality rates worldwide. Although optimized medical therapy, Preservation of lusitropic …

The relationship between home-based parental involvement, parental educational expectation and academic performance of middle school students in mainland …

Y Li, T Hu, T Ge, E Auden - International Journal of Educational Research, 2019 - Elsevier
As China continues to develop rapidly, Chinese parents are increasingly focused on their
children’s education. Previous research investigates the relationship between parental …

High-mobility group AT-hook 1 promotes cardiac dysfunction in diabetic cardiomyopathy via autophagy inhibition

QQ Wu, C Liu, Z Cai, Q Xie, T Hu, M Duan, H Wu… - Cell death & …, 2020 - nature.com
High-mobility group AT-hook1 (HMGA1, formerly HMG-I/Y), an architectural transcription
factor, participates in a number of biological processes. However, its effect on cardiac …