MicroRNAs (miRNAs), a class of small non-coding RNA molecules, are responsible for RNA
silencing and post-transcriptional regulation of gene expression. They can mediate a fine-…

Here, we demonstrate that protein-coding RNA transcripts can crosstalk by competing for
common microRNAs, with microRNA response elements as the foundation of this interaction. …

Stem-cell function is an exquisitely regulated process. Thus far, the contribution of metabolic
cues to stem-cell function has not been well understood. Here we identify a previously …

We recently proposed that competitive endogenous RNAs (ceRNAs) sequester microRNAs
to regulate mRNA transcripts containing common microRNA recognition elements (MREs). …

Tumor cells metastasize to distant organs through genetic and epigenetic alterations,
including changes in microRNA (miR) expression. Here we find miR-22 triggers epithelial-…

MicroRNAs are frequently deregulated in cancer. Here we show that miR-22 is upregulated
in myelodysplastic syndrome (MDS) and leukemia and its aberrant expression correlates …

Competitive endogenous (ce)RNAs cross-regulate each other through sequestration of
shared microRNAs and form complex regulatory networks based on their microRNA signature. …

Research over the past decade has suggested important roles for pseudogenes in physiology
and disease. In vitro experiments demonstrated that pseudogenes contribute to cell …

Primary Sclerosing Cholangitis (PSC) is a persistent inflammatory liver condition that affects
the bile ducts and is commonly diagnosed in young individuals. Despite efforts to …

DNA hypomethylation in certain genes is associated with tobacco exposure but it is
unknown whether these methylation changes translate into increased lung cancer risk. In an …