In the G protein-coupled receptor rhodopsin, the conserved NPxxY(x) 5,6 F motif connects
the transmembrane helix VII and the cytoplasmic helix 8. The less geometrically constrained …

Mutations in the retinal pigment epithelium gene encoding RPE65 are a cause of the incurable
early-onset recessive human retinal degenerations known as Leber congenital amaurosis…

Protein conformational disorders, which include certain types of retinitis pigmentosa, are a set
of inherited human diseases in which mutant proteins are misfolded and often aggregated. …

The visual process is initiated by the photoisomerization of 11-cis-retinal to all-trans- retinal.
For sustained vision the 11-cis-chromophore must be regenerated from all-trans-retinal. This …

The retinoid cycle is a recycling system that replenishes the 11-cis-retinal chromophore of
rhodopsin and cone pigments. Photoreceptor-specific retinol dehydrogenase (prRDH) …

In vertebrate retinal photoreceptors, photoisomerization of opsin-bound visual chromophore
11-cis-retinal to all-trans-retinal triggers phototransduction events. Regeneration of the …

Retinoids carry out essential functions in vertebrate development and vision. Many of the
retinoid processing enzymes remain to be identified at the molecular level. To expand the …

Since the science white paper of the Large High Altitude Air Shower Observatory (LHAASO)
published on arXiv in 2019 [e-Print: 1905.02773 (astro-ph.HE)], LHAASO has completed the …

Increased exposure to blue or visible light, fluctuations in oxygen tension, and the excessive
accumulation of toxic retinoid byproducts places a tremendous amount of stress on the …

Most serine cycle methylotrophic bacteria lack isocitrate lyase and convert acetyl coenzyme
A (acetyl-CoA) to glyoxylate via a novel pathway thought to involve butyryl-CoA and …