Tubular unimolecular transmembrane channels: construction strategy and transport activities

W Si, P Xin, ZT Li, JL Hou - Accounts of chemical research, 2015 - ACS Publications
Conspectus Lipid bilayer membranes separate living cells from their environment. Membrane
proteins are responsible for the processing of ion and molecular inputs and exports, …

Promising reagents for difluoroalkylation

DQ Dong, H Yang, JL Shi, WJ Si, ZL Wang… - Organic Chemistry …, 2020 - pubs.rsc.org
This review describes recent advances in difluoroalkylation reactions using different
substrates. Generally speaking, RCF2 radical is generally proposed in the mechanism of these …

Prevalence of depressive symptoms in primary school students in China: a systematic review and meta-analysis

DD Xu, WW Rao, XL Cao, SY Wen, FR An… - Journal of Affective …, 2020 - Elsevier
Backgrounds Depression in children and adolescents is usually under-recognized. The
findings of epidemiological studies on depressive symptoms in primary school students are …

Pan-cancer single-cell landscape of tumor-infiltrating T cells

L Zheng, S Qin, W Si, A Wang, B Xing, R Gao, X Ren… - Science, 2021 - science.org
INTRODUCTION Cancer immunotherapies that target tumor-specific T cells have benefited
many cancer patients, but the clinical efficacy varies greatly among different cancer types. …

Selective artificial transmembrane channels for protons by formation of water wires.

W Si, L Chen, XB Hu, G Tang, Z Chen… - … (International ed. in …, 2011 - europepmc.org
Lined up water molecules: Artificial transmembrane channels from pillar [5] arene monomeric
and dimeric derivatives have been prepared. Single-channel conductance measurements …

Chiral selective transmembrane transport of amino acids through artificial channels

L Chen, W Si, L Zhang, G Tang, ZT Li… - Journal of the American …, 2013 - ACS Publications
Peptide-appended pillar[n]arene (n = 5, 6) derivatives have been synthesized. H NMR and
IR studies revealed that the molecules adopt a tubular conformation in solution and lipid …

Voltage‐driven reversible insertion into and leaving from a lipid bilayer: Tuning transmembrane transport of artificial channels

W Si, ZT Li, JL Hou - Angewandte Chemie International Edition, 2014 - Wiley Online Library
Three new artificial transmembrane channel molecules have been designed and
synthesized by attaching positively charged Arg‐incorporated tripeptide chains to pillar[5]arene. …

Highly permeable artificial water channels that can self-assemble into two-dimensional arrays

Y Shen, W Si, M Erbakan, K Decker, R De Zorzi… - Proceedings of the …, 2015 - pnas.org
Bioinspired artificial water channels aim to combine the high permeability and selectivity of
biological aquaporin (AQP) water channels with chemical stability. Here, we carefully …

Prevalence of depressive symptoms in children and adolescents in China: a meta-analysis of observational studies

WW Rao, DD Xu, XL Cao, SY Wen, WI Che, CH Ng… - Psychiatry …, 2019 - Elsevier
Depressive symptoms are common in children and adolescents. The prevalence of depressive
symptoms in children and adolescents in China vary significantly across studies. A meta-…

TLR4/NF-κB signaling induces GSDMD-related pyroptosis in tubular cells in diabetic kidney disease

Y Wang, X Zhu, S Yuan, S Wen, X Liu… - Frontiers in …, 2019 - frontiersin.org
Gasdermin D (GSDMD) has been proven to be a key protein in the activation of pyroptosis.
Pyroptosis of renal tubular epithelial cells contributes to the progression of tubular injury in …