User profiles for Xu He

Xu He

NJUST
Verified email at njust.edu.cn
Cited by 8092

Amyloid beta: structure, biology and structure-based therapeutic development

…, Y Yan, Y Zhou, Y Jiang, K Melcher, HE Xu - Acta pharmacologica …, 2017 - nature.com
Amyloid beta peptide (Aβ) is produced through the proteolytic processing of a transmembrane
protein, amyloid precursor protein (APP), by β-and γ-secretases. Aβ accumulation in the …

Targeting integrin pathways: mechanisms and advances in therapy

X Pang, X He, Z Qiu, H Zhang, R Xie, Z Liu… - … and Targeted Therapy, 2023 - nature.com
Integrins are considered the main cell-adhesion transmembrane receptors that play multifaceted
roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in biochemical …

Androgen receptor: structure, role in prostate cancer and drug discovery

MH Tan, J Li, HE Xu, K Melcher, E Yong - Acta Pharmacologica Sinica, 2015 - nature.com
Androgens and androgen receptors (AR) play a pivotal role in expression of the male phenotype.
Several diseases, such as androgen insensitivity syndrome (AIS) and prostate cancer, …

Quantifying the triboelectric series

…, X He, G Dai, H Zheng, C Chen, AC Wang, C Xu… - Nature …, 2019 - nature.com
Triboelectrification is a well-known phenomenon that commonly occurs in nature and in our
lives at any time and any place. Although each and every material exhibits triboelectrification…

Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir

…, Y Jiang, H Jiang, Y Xu, S Zhang, Y Zhang, HE Xu - Science, 2020 - science.org
The pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has become a global crisis. Replication of SARS-…

On the electron‐transfer mechanism in the contact‐electrification effect

C Xu, Y Zi, AC Wang, H Zou, Y Dai, X He… - Advanced …, 2018 - Wiley Online Library
A long debate on the charge identity and the associated mechanisms occurring in contact‐electrification
(CE) (or triboelectrification) has persisted for many decades, while a conclusive …

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

…, RC Stevens, V Cherezov, K Melcher, HE Xu - Nature, 2015 - nature.com
G-protein-coupled receptors (GPCRs) signal primarily through G proteins or arrestins. Arrestin
binding to GPCRs blocks G protein interaction and redirects signalling to numerous G-…

DWARF 53 acts as a repressor of strigolactone signalling in rice

…, L Zhao, H Ma, Y He, Z Wu, K Melcher, Q Qian, HE Xu… - Nature, 2013 - nature.com
Strigolactones (SLs) are a group of newly identified plant hormones that control plant shoot
branching. SL signalling requires the hormone-dependent interaction of DWARF 14 (D14), a …

Molecular recognition of fatty acids by peroxisome proliferator–activated receptors

HE Xu, MH Lambert, VG Montana, DJ Parks… - Molecular cell, 1999 - cell.com
The peroxisome proliferator–activated receptors (PPARs) are nuclear receptors for fatty
acids (FAs) that regulate glucose and lipid homeostasis. We report the crystal structure of the …

A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport

…, ML Sznaidman, MH Lambert, HE Xu… - Proceedings of the …, 2001 - pnas.org
The peroxisome proliferator-activated receptors (PPARs) are dietary lipid sensors that
regulate fatty acid and carbohydrate metabolism. The hypolipidemic effects of the fibrate drugs …