It has been reported that ACE2 is the main host cell receptor of 2019-nCoV and plays a
crucial role in the entry of virus into the cell to cause the final infection. To investigate the …

Signalling by the Wnt family of secreted lipoproteins has essential functions in development
and disease 1 . The canonical Wnt/β-catenin pathway requires a single-span …

Canonical Wnt/β-catenin signaling has central roles in development and diseases, and is
initiated by the action of the frizzled (Fz) receptor, its coreceptor LDL receptor-related protein 6 (…

The secreted protein Sonic hedgehog (Shh) exerts many of its patterning effects through a
combination of short- and long-range signalling 1 , 2 , 3 . Three distinct mechanisms, which …

Glucose transporters are essential for metabolism of glucose in cells of diverse organisms
from microbes to humans, exemplified by the disease-related human proteins GLUT1, 2, 3 …

Wnt signaling through the canonical β-catenin pathway plays essential roles in development
and disease. Low-density-lipoprotein receptor-related proteins 5 and 6 (Lrp5 and Lrp6) in …

In humans, mutations in BMPR1A, SMAD4 and PTEN are responsible for juvenile polyposis
syndrome 1 , juvenile intestinal polyposis 2 and Cowden disease 3 , respectively. The …

Tissue engineering has become a promising strategy for repairing damaged cartilage and
bone tissue. Among the scaffolds for tissue-engineering applications, injectable hydrogels …

Large pretrained models have become foundation models leading to breakthroughs in natural
language processing and related fields. Developing foundation models for deciphering …

LDL receptor related proteins 5 and 6 (LRP5/6) and their Drosophila homolog Arrow are
single-span transmembrane proteins essential for Wnt/β-catenin signaling, likely via acting as …