Increased intestinal bile acid absorption contributes to age-related cognitive impairment

…, M Zhao, T Bao, T Chen, A Zhao, X Zheng, X Gu… - Cell Reports …, 2024 - cell.com
Cognitive impairment in the elderly is associated with alterations in bile acid (BA) metabolism.
In this study, we observe elevated levels of serum conjugated primary bile acids (CPBAs) …

Huanglian Jiedu decoction remodels the periphery microenvironment to inhibit Alzheimer's disease progression based on the “brain-gut” axis through multiple …

X Gu, J Zhou, Y Zhou, H Wang, N Si, W Ren… - Alzheimer's Research & …, 2021 - Springer
Background In recent years, excellent results have suggested an association between the “brain-gut”
axis and Alzheimer’s disease (AD) progression, yet the role of the “brain-gut” axis …

Baicalin ameliorates hepatic insulin resistance and gluconeogenic activity through inhibition of p38 MAPK/PGC-1α pathway

P Fang, Y Sun, X Gu, M Shi, P Bo, Z Zhang, L Bu - Phytomedicine, 2019 - Elsevier
Background Although the results of our and other studies show that baicalin can enhance
glucose uptake and insulin sensitivity in skeletal muscle and adipocytes of mice, the specific …

Aboveground Biomass Inversion Based on Object-Oriented Classification and Pearson–mRMR–Machine Learning Model

X Chen, K Yang, J Ma, K Jiang, X Gu, L Peng - Remote Sensing, 2024 - mdpi.com
Cities play a crucial role in the carbon cycle. Measuring urban aboveground biomass (AGB)
is essential for evaluating carbon sequestration. Satellite remote sensing enables large-…

An integrative analysis of Qingfei Paidu Decoction for its anti-HCoV-229E mechanism in cold and damp environment based on the pharmacokinetics, metabolomics …

Y Zhang, X Gu, Y Zhou, N Si, W Gao, B Sun, J Sun, T Li… - Phytomedicine, 2023 - Elsevier
Background The novel coronavirus pneumonia (COVID-19) has spread rapidly around the
world. As a member against the epidemic, Qingfei Paidu Decoction (QFPDD) has been …

High-fat diet alleviates neuroinflammation and metabolic disorders of APP/PS1 mice and the intervention with Chinese medicine

X Fan, B Liu, J Zhou, X Gu, Y Zhou, Y Yang… - Frontiers in Aging …, 2021 - frontiersin.org
Alzheimer's disease (AD) is a progressive neurodegenerative disease caused by the complex
interaction of multiple mechanisms. Recent studies examining the effect of high-fat diet (…

Luteolin: A potential therapeutic agent for respiratory diseases

M Li, X Gu, J Yang, C Zhang, Y Zhou, P Huang… - European Journal of …, 2025 - Elsevier
Acute lung injury, COVID-19, lung cancer, and asthma are a few of the respiratory conditions
that are the main causes of morbidity and mortality worldwide. The increasing incidence …

Resistant ovary syndrome: Two case reports and a literature review of effective controlled ovarian stimulation in IVF

S Zhao, W Zheng, X Gu, G Liang, G Long - Medicine, 2024 - journals.lww.com
Interventions: The patients were subjected to a COS protocol involving pituitary downregulation
followed by ovarian stimulation using recombinant follicle-stimulating hormone (r-FSH) …

Huanglian Jiedu Decoction in the Treatment of the Traditional Chinese Medicine Syndrome “Shanghuo”–An Intervention Study

…, B Bian, X Wei, N Si, A Brantner, X Fan, X Gu… - Frontiers in …, 2021 - frontiersin.org
“Shanghuo” (“excessive internal heat”) is caused by exuberant endogenous fire, which does
not have a comprehensive and systematic traditional Chinese medicine theory. In previous …

Anti-inflammatory and regulatory effects of Huanglian Jiedu Decoction on lipid homeostasis and the TLR4/MyD88 signaling pathway in LPS-induced zebrafish

J Zhou, X Gu, X Fan, Y Zhou, H Wang, N Si… - Frontiers in …, 2019 - frontiersin.org
Huanglian Jiedu decoction (HLJDD) has been used in the clinical treatment of inflammatory
conditions. To clarify the mechanism of its comprehensive anti-inflammatory activities, the …