Cellular and molecular effects of sirtuins in health and disease
Y Horio, T Hayashi, A Kuno, R Kunimoto - Clinical science, 2011 - portlandpress.com
Sirtuins are NAD + -dependent protein deacetylases that are broadly conserved from bacteria
to humans. Because sirtuins extend the lifespan of yeast, worms and flies, much attention …
to humans. Because sirtuins extend the lifespan of yeast, worms and flies, much attention …
Emerging beneficial roles of sirtuins in heart failure
M Tanno, A Kuno, Y Horio, T Miura - Basic research in cardiology, 2012 - Springer
Sirtuins are a highly conserved family of histone/protein deacetylases whose activity can
prolong the lifespan of model organisms such as yeast, worms and flies. In mammalian cells, …
prolong the lifespan of model organisms such as yeast, worms and flies. In mammalian cells, …
Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non–small-cell lung cancer with …
T Mitsudomi, T Kosaka, H Endoh, Y Horio… - Journal of Clinical …, 2005 - ascopubs.org
Purpose To evaluate the relationship between mutations of the epidermal growth factor
receptor (EGFR) gene and the effectiveness of gefitinib treatment in patients with recurrent lung …
receptor (EGFR) gene and the effectiveness of gefitinib treatment in patients with recurrent lung …
Regulation of FOXOs and p53 by SIRT1 modulators under oxidative stress
YS Hori, A Kuno, R Hosoda, Y Horio - PloS one, 2013 - journals.plos.org
Excessive reactive oxygen species (ROS) induce apoptosis and are associated with various
diseases and with aging. SIRT1 (sirtuin-1), an NAD+-dependent protein deacetylase, …
diseases and with aging. SIRT1 (sirtuin-1), an NAD+-dependent protein deacetylase, …
Ramucirumab plus erlotinib in patients with untreated, EGFR-mutated, advanced non-small-cell lung cancer (RELAY): a randomised, double-blind, placebo-controlled …
…, Y Goto, Y Hosomi, H Sakai, Y Takiguchi… - The Lancet …, 2019 - thelancet.com
Background Dual blockade of the EGFR and VEGF pathways in EGFR-mutated metastatic
non-small-cell lung cancer (NSCLC) is supported by preclinical and clinical data, yet the …
non-small-cell lung cancer (NSCLC) is supported by preclinical and clinical data, yet the …
Induction of coronary artery spasm by acetylcholine in patients with variant angina: possible role of the parasympathetic nervous system in the pathogenesis of …
H Yasue, Y Horio, N Nakamura, H Fujii, N Imoto… - Circulation, 1986 - ahajournals.org
We injected acetylcholine (ACh), the neurotransmitter of the parasympathetic nervous
system, into the coronary arteries of 28 patients with variant angina. Injection of 10 to 80 …
system, into the coronary arteries of 28 patients with variant angina. Injection of 10 to 80 …
Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1
…, J Sakamoto, T Miura, K Shimamoto, Y Horio - Journal of Biological …, 2007 - jbc.org
Sir2 (silent information regulator 2) is an NAD + -dependent histone deacetylase that
contributes to longevity in yeast. SIRT1, a mammalian Sir2 ortholog, deacetylates histones and …
contributes to longevity in yeast. SIRT1, a mammalian Sir2 ortholog, deacetylates histones and …
A novel sulfonylurea receptor forms with BIR (Kir6. 2) a smooth muscle type ATP-sensitive K+ channel
…, Y Horio, Y Matsuzawa, Y Kurachi - Journal of Biological …, 1996 - jbc.org
We have isolated a cDNA encoding a novel isoform of the sulfonylurea receptor from a mouse
heart cDNA library. Coexpression of this isoform and BIR (Kir6.2) in a mammalian cell line …
heart cDNA library. Coexpression of this isoform and BIR (Kir6.2) in a mammalian cell line …
Sulphonylurea receptor 2B and Kir6. 1 form a sulphonylurea‐sensitive but ATP‐insensitive K+ channel.
…, C Kondo, T Shindo, Y Horio, Y Kurachi - The Journal of …, 1997 - Wiley Online Library
1. We analysed the K+ channel composed of the sulphonylurea receptor 2B (SUR2B) and
an inwardly rectifying K+ channel subunit Kir6.1 coexpressed in a mammalian cell line, …
an inwardly rectifying K+ channel subunit Kir6.1 coexpressed in a mammalian cell line, …
Immunogold evidence suggests that coupling of K+ siphoning and water transport in rat retinal Müller cells is mediated by a coenrichment of Kir4.1 and AQP4 in …
EA Nagelhus, Y Horio, A Inanobe, A Fujita, F Haug… - Glia, 1999 - Wiley Online Library
Postembedding immunogold labeling was used to examine the subcellular distribution of the
inwardly rectifying K+ channel Kir4. 1 in rat retinal Müller cells and to compare this with the …
inwardly rectifying K+ channel Kir4. 1 in rat retinal Müller cells and to compare this with the …