Despite advances in treatment, cancer remains the 2nd most common cause of death in the
United States. Poor cure rates may result from the ability of cancer to recur and spread after …

Overexpression of the deubiquitylase ubiquitin-specific peptidase 22 (USP22) is a marker of
aggressive cancer phenotypes like metastasis, therapy resistance, and poor survival. …

Fragile X-related protein-1 (FXR1) gene is highly amplified in patients with ovarian cancer,
and this amplification is associated with increased expression of both FXR1 mRNA and …

This study uncovers a role for OSMR in promoting ovarian cancer cell proliferation and
metastasis by activating STAT3 signaling and demonstrates the preclinical efficacy of antibody-…

PURPOSE: The development of drug-resistant phenotypes has been a major obstacle to
cisplatin use in non–small-cell lung cancer. We aimed to identify some of the molecular …

Introduction: Persistent STAT3 activation contributes to lung carcinogenesis. Survivin, one of
STAT3-regulated genes, is antiapoptotic and confers cancer radioresistance. Methods: We …

Increased breast cancer (BC) mortality risk posed by delayed surgical resection of tumor
after diagnosis is a growing concern, yet the underlying mechanisms remain unknown. Our …

Introduction Defects in the apoptosis pathway limit the effectiveness of radiation in non-small
cell lung cancer (NSCLC) therapy. BV6 is an antagonist of cIAP1 and XIAP, members of the …

Insulin-like growth factor binding protein 3 (IGFBP3) modulates cell growth through IGF-dependent
and -independent mechanisms. Reports suggest that the serum levels of IGFBP3 are …

Crizotinib (PF02341066) is a tyrosine kinase inhibitor of anaplastic lymphoma kinase (ALK)
that has been shown to selectively inhibit growth of cancer cells that harbor the EML4-ALK …