Global producer responsibility for plastic pollution

…, TA Farrelly, BD Hardesty, K Kerge, N Li, Y Li… - Science …, 2024 - science.org
Brand names can be used to hold plastic companies accountable for their items found
polluting the environment. We used data from a 5-year (2018–2022) worldwide (84 countries) …

Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation

XC Dong, KD Copps, S Guo, Y Li, R Kollipara… - Cell metabolism, 2008 - cell.com
The forkhead transcription factor Foxo1 regulates expression of genes involved in stress
resistance and metabolism. To assess the contribution of Foxo1 to metabolic dysregulation …

Dysregulation of insulin receptor substrate 2 in β cells and brain causes obesity and diabetes

X Lin, A Taguchi, S Park, JA Kushner, F Li, Y Li… - The Journal of clinical …, 2004 - jci.org
The molecular link between obesity and β cell failure that causes diabetes is difficult to establish.
Here we show that a conditional knockout of insulin receptor substrate 2 (Irs2) in mouse …

A multi-material topology optimization approach to hybrid material structures with gradient lattices

Y Li, W Qiu, Z Liu, Y Liu, L Xia - Computer Methods in Applied Mechanics …, 2024 - Elsevier
In this paper, we present a novel approach for designing hybrid material structures that
incorporate solid, void, and spatially-varying lattices. This approach extends the recursively …

Insulin and metabolic stress stimulate multisite serine/threonine phosphorylation of insulin receptor substrate 1 and inhibit tyrosine phosphorylation

NJ Hançer, W Qiu, C Cherella, Y Li, KD Copps… - Journal of Biological …, 2014 - jbc.org
IRS1 and IRS2 are key substrates of the insulin receptor tyrosine kinase. Mass spectrometry
reveals more than 50 phosphorylated IRS1 serine and threonine residues (Ser(P)/Thr(P) …

Bladder oxidative stress in sleep apnea contributes to detrusor instability and nocturia

MW Witthaus, F Nipa, JH Yang, Y Li… - The Journal of …, 2015 - auajournals.org
Purpose : Obstructive sleep apnea is associated with voiding symptoms in humans and
animals, and yet its effects on the urinary tract are poorly understood. We examined bladder …

[PDF][PDF] Structural modifications of the prostate in hypoxia, oxidative stress, and chronic ischemia

P Thurmond, JH Yang, Y Li, LB Lerner… - Korean journal of …, 2015 - synapse.koreamed.org
Purpose: Clinical studies have reported a correlation between pelvic ischemia and voiding
dysfunction in elderly men. The aim of this study was to identify and compare prostate …

Understanding China's Court Mediation Surge: Insights from a Local Court

Y Li, J Kocken, B Van Rooij - Law & Social Inquiry, 2018 - cambridge.org
This article seeks to understand how reported mediation rates in Chinese courts are produced
and what they actually signify. It analyzes data obtained through prolonged fieldwork at a …

Antioxidant and metabolic responses induced by cadmium and pyrene in the earthworm Eisenia fetida in two different systems: contact and soil tests

X Zhang, Y Lu, Y Shi, C Chen, Z Yang, Y Li… - Chemistry and …, 2009 - Taylor & Francis
The effects of cadmium and the polycyclic aromatic hydrocarbon (PAH) pyrene on the
earthworm Eisenia fetida were investigated in contact and soil tests. Metabolic (glutathione-S-…

Cucurbitane-type triterpenes from the tubers of Hemsleya penxianensis and their bioactive activity

N Zhu, Z Sun, M Hu, Y Li, D Zhang, H Wu, Y Tian, P Li… - Phytochemistry, 2018 - Elsevier
The tubers of the medicinal plant Hemsleya penxianensis (Cucurbitaceae) yielded 11
cucurbitane-type triterpenes Xuedanencins AK by silica gel column, ODS column, and pre-HPLC …