Caspase-2 is one of the earliest identified caspases, but the mechanism of caspase-2-induced
apoptosis remains unknown. We show here that caspase-2 engages the mitochondria-…

Aberrant activation of Bruton’s tyrosine kinase (BTK) plays an important role in pathogenesis
of B-cell lymphomas, suggesting that inhibition of BTK is useful in the treatment of …

OBJECTIVE: The purpose of this study was to perform a comprehensive analysis of the
microRNA expression profile in placentas from preeclamptic pregnancies vs normal placentas. …

A palladium-catalyzed intramolecular oxidative aryltrifluoromethylation reaction of activated
alkenes has been explored. The reaction allows for an efficient synthesis of a variety of CF 3 -…

Material properties and selection are very important in product design. To get more sustainable
products, not only the technical and economic factors, but also the environmental factors …

A novel fluorescent probe was developed by integrating chlorinated coumarin and
benzothiazolylacetonitrile and exploited for simultaneous detection of cysteine (Cys), homocysteine (…

The caspase recruitment domain (CARD) is a protein-binding module that mediates the
assembly of CARD-containing proteins into apoptosis and NF-κB signaling complexes. We …

There is considerable potential for integrating transarterial chemoembolization (TACE),
programmed death-(ligand)1 (PD-[L]1) inhibitors, and molecular targeted treatments (MTT) in …

This study was aimed to develop a new practical ligament scaffold by synergistic incorporation
of silk fibers, a knitted structure, and a collagen matrix. The efficacy for ligament tissue …

Turnover and exchange of nucleosomal histones and their variants, a process long believed
to be static in post-replicative cells, remains largely unexplored in brain. Here, we describe …