Over the past decade, PAS domains have been identified in dozens of signal transduction
molecules and various forms have been found in animals, plants, and prokaryotes. In this …

We report that MOP3 is a general dimerization partner for a subset of the basic-helix–loop–helix
(bHLH)-PER–ARNT–SIM (PAS) superfamily of transcriptional regulators. We …

Hypoxia inducible factors (HIFs) are heterodimeric transcription factors that regulate a
number of adaptive responses to low oxygen tension. They are composed of α- and β-subunits …

In an effort to better understand the mechanism of toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin,
we employed an iterative search of human expressed sequence tags to identify novel …

The first formal qualification of safety biomarkers for regulatory decision making marks a
milestone in the application of biomarkers to drug development. Following submission of drug …

The aryl hydrocarbon receptor (AHR) and the α-class hypoxia inducible factors (HIF1α, HIF2α,
and HIF3α) are basic helix-loop-helix PAS (bHLH-PAS) proteins that heterodimerize with …

The genotoxicity testing battery is highly sensitive for detection of chemical carcinogens.
However, it features a low specificity and provides only limited mechanistic information required …

Application of any new biomarker to support safety-related decisions during regulated phases
of drug development requires provision of a substantial data set that critically assesses …

PAS (PER, ARNT, SIM) proteins play important roles in adaptation to low atmospheric and
cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations …

Phospholipidosis (PLD) is characterized by the excessive intracellular accumulation of
phospholipids. It is well established that a large number of cationic amphiphilic drugs have the …