Initially identified as an actin-binding protein containing a PSD95-DLG-ZO1 Domain (PZD
domain), Synaptopodin 2 (SYNPO2) has long been considered a structural protein …

The clinical application of doxorubicin (DOX) is limited due to its cardiotoxicity, which is
primarily attributed to its interaction with iron in mitochondria, leading to lipid peroxidation and …

Predicting a landslide susceptibility map (LSM) is essential for risk recognition and disaster
prevention. Despite the successful application of data-driven approaches for LSM prediction, …

The challenge posed by opioid overdose has become a significant concern for health systems
due to the complexities associated with drug prohibition, widespread clinical use, and …

Gastrointestinal (GI) cancers constitute the largest portion of all human cancers, and the
most prevalent GI cancers in China are colorectal cancer (CRC), gastric cancer (GC), and …

Background: Major depressive disorder (MDD) plays a crucial role in the occurrence of heart
failure (HF). This investigation was undertaken to explore the possible mechanism of MDD’…

From carrying potentially pathogenic genes to severe clinical phenotypes, the basic research
in the inherited cardiac ion channel disease such as long QT syndrome (LQTS) has been a …

Chronic heart failure (CHF) can induce chronic kidney disease (CKD), called type 2 cardio-renal
syndrome (CRS2). The mechanism is not completely clear, and there is a lack of early …

Objective To demonstrate that a 3D-bioprinted integrated osteochondral scaffold can provide
improved repair of articular cartilage defects in the rabbit knee compared to that reported …

Identifying oncogenes that promote cancer cell proliferation or survival is critical for treatment
of colorectal cancer. The Brother of Regulator of Imprinted Sites (BORIS) is frequently …