Predicting Phase 3 clinical trial results is a critical step of Go/No-Go decision making and
Phase 3 trial design optimization. To predict the overall treatment effect for patients enrolled …

Compressed sensing is a signal processing technique used to efficiently acquire and
reconstruct signals across various fields, including science, engineering, and business. A critical …

Background: Colorectal cancer (CRC) is one of the most prevalent cancers worldwide and
is closely linked to the gut microbiota. Identifying reproducible and generalizable microbial …

The increasing access to large social network data has generated substantial interest in the
marketing community. However, due to its large scale, traditional analysis methods often …

Successful prediction of clinical outcomes facilitates tailored diagnosis and treatment. The
microbiome has been shown to be an important biomarker to predict host clinical outcomes. …

The supersaturated design is often used to discover important factors in an experiment with
a large number of factors and a small number of runs. We propose a method for constructing …

Background 2021 World Health Organization (WHO) Central Nervous System (CNS) tumor
classification increasingly emphasizes the important role of molecular markers in glioma …

This study introduced a process for synthesizing mesoporous silicon@nano-bioactive glass
(nano-BAG) complex particles, and evaluated their effects on dentin bonding and …

In the field of hyperspectral unmixing (HU), accurately determining the spectral signatures of
pure materials (end-members) and their abundances presents significant challenges. …

The thesis consists of two topics. The first topic is construction of supersaturated designs.
Supersaturated designs are often used to discover important factors in an experiment with a …