From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations
…, AN Chiang, SA Houck, Z Cai… - Molecular biology of …, 2016 - molbiolcell.org
More than 2000 mutations in the cystic fibrosis transmembrane conductance regulator (CFTR)
have been described that confer a range of molecular cell biological and functional …
have been described that confer a range of molecular cell biological and functional …
Schwann cells in pancreatic cancer: Unraveling their multifaceted roles in tumorigenesis and neural interactions
Z Cai, H Yao, J Chen, AA Ahmed, C Li, X Hu, X Tang… - Cancer letters, 2024 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC), characterized by heightened neural density,
presents a challenging prognosis primarily due to perineural invasion. Recognized for their …
presents a challenging prognosis primarily due to perineural invasion. Recognized for their …
Triglyceride-glucose index trajectory and stroke incidence in patients with hypertension: a prospective cohort study
…, Q Yue, X Wang, Z Chen, Z Cai, W Li, Z Cai… - Cardiovascular …, 2022 - Springer
Background It has been suggested that the baseline triglyceride-glucose (TyG) index, a simple
surrogate measure for insulin resistance, is significantly associated with the occurrence of …
surrogate measure for insulin resistance, is significantly associated with the occurrence of …
Understanding how cystic fibrosis mutations disrupt CFTR function: from single molecules to animal models
Y Wang, JA Wrennall, Z Cai, H Li… - The international journal of …, 2014 - Elsevier
Defective epithelial ion transport is the hallmark of the life-limiting genetic disease cystic
fibrosis (CF). This abnormality is caused by mutations in the cystic fibrosis transmembrane …
fibrosis (CF). This abnormality is caused by mutations in the cystic fibrosis transmembrane …
Electrode materials for electrochromic supercapacitors
J Li, H Yu, Y Lv, Z Cai, Y Shen, L Ruhlmann… - …, 2024 - iopscience.iop.org
Smart energy storage systems, such as electrochromic supercapacitor (ECSC) integrated
technology, have drawn a lot of attention recently, and numerous developments have been …
technology, have drawn a lot of attention recently, and numerous developments have been …
Alteration of protein function by a silent polymorphism linked to tRNA abundance
S Kirchner, Z Cai, R Rauscher, N Kastelic… - PLoS …, 2017 - journals.plos.org
Synonymous single nucleotide polymorphisms (sSNPs) are considered neutral for protein
function, as by definition they exchange only codons, not amino acids. We identified an sSNP …
function, as by definition they exchange only codons, not amino acids. We identified an sSNP …
Revertant mutants G550E and 4RK rescue cystic fibrosis mutants in the first nucleotide-binding domain of CFTR by different mechanisms
M Roxo-Rosa, Z Xu, A Schmidt, M Neto, Z Cai… - Proceedings of the …, 2006 - pnas.org
The revertant mutations G550E and 4RK [the simultaneous mutation of four arginine-framed
tripeptides (AFTs): R29K, R516K, R555K, and R766K] rescue the cell surface expression …
tripeptides (AFTs): R29K, R516K, R555K, and R766K] rescue the cell surface expression …
Residual function of cystic fibrosis mutants predicts response to small molecule CFTR modulators
…, AF McCague, TA Evans, AT Joynt, Z Lu, Z Cai… - JCI …, 2018 - pmc.ncbi.nlm.nih.gov
Treatment of individuals with cystic fibrosis (CF) has been transformed by small molecule
therapies that target select pathogenic variants in the CF transmembrane conductance …
therapies that target select pathogenic variants in the CF transmembrane conductance …
Dynamic recrystallization behavior and hot workability of AZ41M magnesium alloy during hot deformation
Z Cai, F Chen, F Ma, J Guo - Journal of Alloys and Compounds, 2016 - Elsevier
… Author links open overlay panel Zhiwei Cai a , Fuxiao Chen a c , Fengjie Ma b , Junqing
Guo a c … ZW Cai, FX Chen, JQ Guo … Wang, ZY Chen, FC Wang, HN Cai …
Guo a c … ZW Cai, FX Chen, JQ Guo … Wang, ZY Chen, FC Wang, HN Cai …
Relationship of cumulative exposure to the triglyceride-glucose index with ischemic stroke: a 9-year prospective study in the Kailuan cohort
…, B Feng, Z Huang, Z Cai, X Yu, Z Chen, Z Cai… - Cardiovascular …, 2022 - Springer
Background A single measurement of the triglyceride-glucose (TyG) index, a simple and
reliable surrogate marker of insulin resistance, is associated with ischemic stroke. However, …
reliable surrogate marker of insulin resistance, is associated with ischemic stroke. However, …