1785122199
COMPARISON OF ORAL AND PARENTERAL GENTAMICIN (G) IN THE PREVENTION OF ENTERALLY-ACQUIRED PSEUDOMONAS (PS) SEPSIS
Pediatr Res, 1987
We evaluated the protective effect of oral and parenteral G in the leukopenic mouse. C3H/HeN mice were made leukopenic by injection of cyclophosphamide. Mice were either gavage fed (po) or injected (ip) with G in 5% glucose water (D5W) at 5, 10, or 15 mg/kg/day (days 1-7). On day 4 the animals were orogastrically inoculated with Ps. aeruginosa, immunotype 7 (ATCC #27318) in D5W. Survival of treatment groups were compared by 2-way ANOVA. RESULTS: The MIC of G for PS is 2 μg/ml. Protection by G is significantly related to dose [F(2,55)=5.65, p=0.0059]. Prophylactic G is more protective at 15 mg/kg/day than 5 mg/kg/day (p
1785122199
On the existence of minimisers for strain‐gradient single‐crystal plasticity
Z Angew Math Mech, 2017
We prove the existence of minimisers for a family of models related to the single-slip-to-single-plane relaxation of single-crystal, strain-gradient elastoplasticity with -hardening penalty. In these relaxed models, where only one slip-plane normal can be activated at each material point, the main challenge is to show that the energy of geometrically necessary dislocations is lower-semicontinuous along bounded-energy sequences which satisfy the single-plane condition, meaning precisely that this side condition should be preserved in the weak -limit. This is done with the aid of an ‘exclusion’ lemma of Conti & Ortiz, which essentially allows one to put a lower bound on the dislocation energy at interfaces of (single-plane) slip patches, thus precluding fi...
1785122199
Determination of oxytocin in a dilute IV solution by LC–MSn
Journal of Pharmaceutical and Biomedical Analysis, 2008
The most common drug prescribed to induce labor in the United States is oxytocin, a peptide hormone composed of nine amino acids. Oxytocin is often reconstituted in intravenous (IV) saline solutions at less than 0.05 units ml−1 (125 ng ml−1) to be delivered at 1–4 drops per minute. Existing LC–UV methods for oxytocin do not have sufficient detection limits to quantitate and/or confirm oxytocin in IV solutions without sample concentration. A determinative and confirmatory method for oxytocin was developed using an LC–MSn ion trap instrument with an electrospray ionization (ESI) interface in positive ion mode. Separation was achieved on a C-18 column using an isocratic elution of water with 50% acetonitrile (v/v) and water with 0.05% formic acid (v/v...
1785122199
Maternal Obesity during the Preconception and Early Life Periods Alters Pancreatic Development in Early and Adult Life in Male Mouse Offspring
PLoS ONE, 2013
Maternal obesity induced by a high fat (HF) diet may program susceptibility in offspring, altering pancreatic development and causing later development of chronic degenerative diseases, such as obesity and diabetes. Female mice were fed standard chow (SC) or an HF diet for 8 weeks prior to mating and during the gestational and lactational periods. The male offspring were assessed at birth, at 10 days, and at 3 months of age. The body mass (BM) gain was 50% greater before pregnancy and 80% greater during pregnancy in HF dams than SC dams. Dams fed an HF diet showed higher oral glucose tolerance test (OGTT), blood pressure, serum corticosterone, and insulin levels than dams fed SC. At 10 days of age and at 3 mo old the HF offspring showed greater BM and higher...
1785122199
Dopamine transporter SPECT: How to remove subjectivity?
Movement Disorders, 2009
Clinical criteria enable accurate and reliable diagnosis of parkinsonian syndromes when cardinal clinical features are fully developed. Single photon emission computed tomography (SPECT) investigating the striatal dopamine transporter (DAT) status have been suggested to increase the diagnostic accuracy in uncertain parkinsonian syndromes such as isolated tremor symptoms not fulfilling essential tremor criteria, as well as drug-induced, vascular and psychogenetic parkinsonism. Several approaches for the analysis of the striatal DAT distribution have been tested for their ability to analyze and quantify SPECT images. Visual assessment of DAT binding and semiquantitative analysis using region of interests have been recommended by Nuclear Medicine Associations t...
1785122198
Fluoride-assisted galvanic replacement synthesis of Ag and Au dendrites on aluminum foil with enhanced SERS and catalytic activities
J. Mater. Chem., 2012
Although Al has a lower redox potential [Al3+/Al, −1.67 V vs. SHE] than most metallic ions, metal galvanic replacement reactions on pure aluminum foil can be hardly observed because of the existence of the thin layer of aluminum oxide, In this work, we develop a facile, economical and general approach to achieve large-scale production of silver and gold dendrites as well as other metal hierarchical micro/nanostructures (Cu, Pt, Pd, Ni, Co and Zn) on commercial aluminum foil in the presence of NaF or NH4F. Studies of the galvanic replacement reaction by open circuit potential–time (OCP–t) measurements demonstrate that fluoride plays an important role in etching the alumina layer and thus induces the continuous proceeding of the galvanic replacement reac...
1785122198
Sex chromosome quadrivalents in oocytes of the African pygmy mouse Mus minutoides that harbors non-conventional sex chromosomes
Chromosoma, 2019
Eutherian mammals have an extremely conserved sex-determining system controlled by highly differentiated sex chromosomes. Females are XX and males XY, and any deviation generally leads to infertility, mainly due to meiosis disruption. The African pygmy mouse (Mus minutoides) presents an atypical sex determination system with three sex chromosomes: the classical X and Y chromosomes and a feminizing X chromosome variant, called X*. Thus, three types of females coexist (XX, XX*, and X*Y) that all show normal fertility. Moreover, the three chromosomes (X and Y on one side and X* on the other side) are fused to different autosomes, which results in the inclusion of the sex chromosomes in a quadrivalent in XX* and X*Y females at meiotic prophase. Here, we characte...
1785122198
Methodology and base cost models to determine the total benefits of preservation interventions on road sections in Switzerland
Structure and Infrastructure Engineering, 2012
In Switzerland, it is common practice to estimate the total benefits of new roads before they have been built and of road improvement interventions before they have been performed. The guidelines with respect to standardised methodologies and models to be used have been developed (VSS 2003a VSS. 2003a. SN 641 820: Cost-benefit analysis in road traffic, Switzerland: Swiss Association of Road and Traffic Experts (VSS). Technical Committee 2: Planning and Development (in German) [Google Scholar]) and are now in use. It is not yet, however, common practice to estimate the total benefits of road preservation interventions and hence guidelines do not exist with respect to standardised methodologies and models to be used. In order to provide this information, the r...
1785122198
UniDoSA: The Unified Specification and Detection of Service Antipatterns
IIEEE Trans. Software Eng., 2019
Service-based Systems (SBSs) are developed on top of diverse Service-Oriented Architecture (SOA) technologies or architectural styles. Like any other complex systems, SBSs face both functional and non-functional changes at the design or implementation-level. Such changes may degrade the design quality and quality of service (QoS) of the services in SBSs by introducing poor solutions—service antipatterns. The presence of service antipatterns in SBSs may hinder the future maintenance and evolution of SBSs. Assessing the quality of design and QoS of SBSs through the detection of service antipatterns may ease their maintenance and evolution. However, the current literature lacks a unified approach for modelling and evaluating the design of SBSs in term of desi...
1785122197
Electromechanical Sigma–Delta Modulators (<inline-formula> <tex-math notation="LaTeX">$\Sigma \Delta {\mathrm{ M}}$ </tex-math> </inline-formula>) Force Feedback Interfaces for Capacitive MEMS Inertial Sensors: A Review
IEEE Sensors J., 2016
Analog-to-digital converters based on sigma–delta modulators ( $\Sigma \Delta {\mathrm{ M}}$ ) are a popular choice for high resolution conversion from the analog to the digital domain. With relatively small modifications, they can also be used as electromechanical $\Sigma \Delta {\mathrm{ M}}$ (EM- $\Sigma \Delta {\mathrm{ M}}$ ) force feedback interfaces for capacitive micro-electromechanical systems (MEMSs) inertial sensors. Such interfaces are able to combine the benefits of force feedback and analog-to-digital conversion at relatively modest circuit cost. This paper provides a comprehensive review of EM- $\Sigma \Delta {\mathrm{ M}}$ interfaces for capacitive MEMS inertial sensors. The principle and the design methodology of EM- $\Sigma \Delta {\mathr...
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ChemInform Abstract: Thiourea: A Novel Cleaving Agent for 1,3‐Dioxolanes.
ChemInform, 1999
One of the most common methods of protecting aldehydes,
ketones, and vicinal diols involves the formation
of acetals. Aldehydes and ketones are usually protected
as their 1,3-dioxolane derivatives, and vicinal diols such
as those present in carbohydrate derivatives are protected
as 2,2-dimethyl-1,3-dioxolanes. Several methods
are available for deprotecting these types of acetals,
which mostly utilize acidic cleaving methods.1 Other
cleaving methods involving the use of silica gel2 or
lithium tetrafluoroborate in wet acetonitrile3 and some
nonaqueous cleaving methods have also been reported
for this purpose.4-6 Herein we report that thiourea can
effect the cleavage of 1,3-dioxolanes derived from aldehydes
and ketones, as well as the selective cleavage of
the ...
1785122197
Modeling and controller design of a micro gas turbine for power generation
ISA Transactions, 2022
This paper investigates the modeling and controller design of a micro gas turbine in power generation scenario. From the perspective of the controller design, it is well recognized that an accurate model in possession of the complex dynamic characteristics of a micro gas turbine is paramount. Thus, a nominal nonlinear model originated from integrating the start-up model and the component characteristic map model together is established to depict the main operating modes of the full operation envelope, containing the start-up mode, loading mode and unloading mode. The start-up model is got by the combination of polynomial fitting method with identification method. The component characteristic map model is achieved by combining inter-component volume method wi...
1785122197
Articulation in apraxia of speech
SAJCD, 1976
In an attempt to show that aphasics with apraxia of speech have characteristic articulatory patterns, two aphasics with apraxia of speech, and one subject with articulatory problems related to his sensory aphasia, underwent articulation testing. A quantitative measure of distance between error sound and target sound showed that the types of aphasics did not differ on distance, and apraxics could therefore not be said to be closer to the target sound than a sensory aphasic. However, the more severe the communication disorder, the higher was the distance score. A qualitative analysis of the data revealed that the apraxics had substitutions of phonemes as their major error, whereas in the subject without apraxia, substitutions were as prevalent as other errors ...
1785122197
Neutralizing Antibodies Induced by Gene-Based Hydrodynamic Injection Have a Therapeutic Effect in Lethal Influenza Infection
Front. Immunol., 2018
The influenza virus causes annual epidemics and occasional pandemics and is thus a major public health problem. Development of vaccines and antiviral drugs is essential for controlling influenza virus infection. We previously demonstrated the use of vectored immune-prophylaxis against influenza virus infection. We generated a plasmid encoding neutralizing IgG monoclonal antibodies (mAbs) against A/PR/8/34 influenza virus (IAV) hemagglutinin (HA). We then performed electroporation of the plasmid encoding neutralizing mAbs (EP) in mice muscles and succeeded in inducing the expression of neutralizing antibodies in mouse serum. This therapy has a prophylactic effect against lethal IAV infection in mice. In this study, we established a new method of passive immun...
1785122197
‘Voice’ is not enough: conceptualising Article 12 of the United Nations Convention on the Rights of the Child
British Educational Res J, 2007
This article provides a children's rights critique of the concept of ‘pupil voice’. The analysis is founded on Article 12 of the United Nations Convention on the Rights of the Child, which gives children the right to have their views given due weight in all matters affecting them. Drawing on research conducted on behalf of the Northern Ireland Commissioner for Children and Young People, the article assesses some of the barriers to the meaningful and effective implementation of the right within education. It is argued that the phrases which are commonly used as abbreviations for Article 12, such as ‘pupil voice’, have the potential to diminish its impact as they provide an imperfect summary of the full extent of the obligation. The article proposes a ...
1785122196
Two-Dimensional Reaction Free Energy Surfaces of Catalytic Reaction: Effects of Protein Conformational Dynamics on Enzyme Catalysis
J. Phys. Chem. B, 2007
We introduce a two-dimensional (2D) multisurface reaction free energy description of the catalytic cycle that explicitly connects the recently observed multi-time-scale conformational dynamics as well as dispersed enzymatic kinetics to the classical Michaelis−Menten equation. A slow conformational motion on a collective enzyme coordinate Q facilitates the catalytic reaction along the intrinsic reaction coordinate X, providing a dynamic realization of Pauling's well-known idea of transition-state stabilization. The catalytic cycle is modeled as transitions between multiple displaced harmonic wells in the XQ space representing different states of the cycle, which is constructed according to the free energy driving force of the cycle. Subsequent to substrate ...
1785122196
The Chemistry behind Antioxidant Capacity Assays
J. Agric. Food Chem., 2005
This review summarizes the multifaceted aspects of antioxidants and the basic kinetic models of inhibited autoxidation and analyzes the chemical principles of antioxidant capacity assays. Depending upon the reactions involved, these assays can roughly be classified into two types: assays based on hydrogen atom transfer (HAT) reactions and assays based on electron transfer (ET). The majority of HAT-based assays apply a competitive reaction scheme, in which antioxidant and substrate compete for thermally generated peroxyl radicals through the decomposition of azo compounds. These assays include inhibition of induced low-density lipoprotein autoxidation, oxygen radical absorbance capacity (ORAC), total radical trapping antioxidant parameter (TRAP), and crocin b...
1785122196
A Study on the Interaction of Rhodamine B with Methylthioadenosine Phosphorylase Protein Sourced from an Antarctic Soil Metagenomic Library
PLoS ONE, 2013
The presented study examines the phenomenon of the fluorescence under UV light excitation (312 nm) of E. coli cells expressing a novel metagenomic-derived putative methylthioadenosine phosphorylase gene, called rsfp, grown on LB agar supplemented with a fluorescent dye rhodamine B. For this purpose, an rsfp gene was cloned and expressed in an LMG194 E. coli strain using an arabinose promoter. The resulting RSFP protein was purified and its UV-VIS absorbance spectrum and emission spectrum were assayed. Simultaneously, the same spectroscopic studies were carried out for rhodamine B in the absence or presence of RSFP protein or native E. coli proteins, respectively. The results of the spectroscopic studies suggested that the fluorescence of E. coli cells expres...
1785122196
Selection of the Geomagnetic Normal Field and Calculation of Geomagnetic Anomalous Field
Chinese J. Geophys., 2005
According to the geomagnetic observation data in China for 2003 from 135 geomagnetic stations and 35 geomagnetic observatories, and the geomagnetic data of 38 IGRF calculated points in China's adjacent regions, the distribution of the geomagnetic anomalous field in China was calculated. Two kinds of geomagnetic models are selected as the geomagnetic normal field: one is the spherical harmonic model of the international geomagnetic reference field, and the other is the Taylor polynomial model of the geomagnetic field in China. Based on the geomagnetic anomaly values (the observed value minus the calculated value of the model) at various stations, the spherical cap harmonic model of the geomagnetic anomalous field was calculated by using the spherical cap harm...
1785122196
Corporate Diversity Programs and Gender Inequality in the Oil and Gas Industry
Work and Occupations, 2014
Since the 1980s, major U.S. corporations have embraced diversity as a management strategy to increase the number of women in top jobs. Diversity management programs include targeted recruitment, hiring, and promotions policies; mentoring programs; affinity groups; and diversity training. Few of these programs have proven effective in achieving gender diversity in the corporate world, despite their widespread popularity. To explore the reasons for this, the authors investigate the experiences of women scientists in the oil and gas industry who are targeted by these programs. In-depth interviews reveal possible reasons why these programs fail to achieve their intended goals. The authors find that these programs can paradoxically reinforce gender inequality and...
1785122196
Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling
Cell, 2020
The fidelity of intracellular signaling hinges on the organization of dynamic activity architectures. Spatial compartmentation was first proposed over 30 years ago to explain how diverse G protein-coupled receptors achieve specificity despite converging on a ubiquitous messenger, cyclic adenosine monophosphate (cAMP). However, the mechanisms responsible for spatially constraining this diffusible messenger remain elusive. Here, we reveal that the type I regulatory subunit of cAMP-dependent protein kinase (PKA), RIα, undergoes liquid-liquid phase separation (LLPS) as a function of cAMP signaling to form biomolecular condensates enriched in cAMP and PKA activity, critical for effective cAMP compartmentation. We further show that a PKA fusion oncoprotein associ...
1785122195
A Rapid and Simple Manifold to Study Exchangeable Cations and Cation Exchange Capacity in 24 Soil Samples Simultaneously
Communications in Soil Science and Plant Analysis, 2019
ABSTRACTThe outcomes of this work highlight the development and validation of a rapid and simple manifold for determination of exchangeable cations [calcium (Ca), magnesium (Mg), sodium (Na), and potassium (K)] and cation exchange capacity (CEC) in soil. First, the performance of the manifold was evaluated to determine the best conditions to use: filter assembly, volume and number of aliquots of extracting solution, and the use of vacuum. Second, the analytical performance was study from trueness and precision analysis. For that, soil samples with assigned values, an in house reference material and unknown soil samples, were used, comparing their results with those obtained using the classical extraction method (agitation, centrifugation, and filtration). Th...
1785122195
Studies of Energetic and Nonenergetic Materials Immersed in Molten Salts
Combustion Science and Technology, 1998
Immersion of energetic materials into molten-salt baths is being considered as a method for their safe destruction. In the present research, a solid energetic material, 2,6-dinitrotoluene (DNT), and a solid nonenergetic material, solidified n-dodecane, were studied. Cylindrical samples initially about 1 cm in diameter were injected into salt baths, and data were taken photographically. As salt temperatures increased, surface regression rates increased. Thin gas films were observed to exist around the samples. In addition, DNT bubbles displayed sudden rapid size increases with strong increases in opacity suggesting that chemical reactions were taking place in the bubbles; these behaviors were not observed with bubbles from the dodecane samples. Temperature p...
1785122195
Ground-glass nodule segmentation in chest CT images using asymmetric multi-phase deformable model and pulmonary vessel removal
Computers in Biology and Medicine, 2018
We propose a ground-glass nodule (GGN) segmentation method that can separate solid component and ground-glass opacity (GGO) using an asymmetric multi-phase deformable model in chest CT images. First, initial solid component and GGO were extracted using intensity-based segmentation with histogram modeling. Second, the initial extracted regions were refined using an asymmetric multi-phase deformable model with modified energy functional and intensity-constrained averaging function. Finally, vessel-like structures are removed based on multi-scale shape analysis. In experiments, the segmentation accuracy of the entire GGN was evaluated using datasets from SNUH and LIDC/IDRI. The average DSC values of Seoul National University Hospital (SNUH) and Lung Image Datab...
1785122195
Selenium Adsorption by Goethite
Soil Science Soc of Amer J, 1987
Abstract The adsorption of Se by goethite was studied as a function of time (10 min–24 h), temperature (295.5 and 303.5 K), pH (4–11), particle concentration (3–300 mg/L), total Se concentration (0.02–5 × 10 −5 M ), oxidation state [Se(IV) and Se(VI)], and competing anion concentration [(anion)/(Se(IV) = 0.25 to 50 000] in order to assess the influence of these factors on Se mobility. The data indicate that (i) the surface sites of goethite are heterogeneous, (ii) the adsorption of selenite [Se(IV)] reaches equilibrium in 2 h and is completely reversible with respect to pH, (iii) the removal of selenite from solution increases with decreasing pH and increasing particle concentration, (iv) the adsorption edge for selenite shifts to lower pH values ...
1785122195
Qualitative assessment of climate-driven ecological shifts in the Caspian Sea
PLoS ONE, 2017
The worldwide occurrence of complex climate-induced ecological shifts in marine systems is one of the major challenges in sustainable bio-resources management. The occurrence of ecological environment-driven shifts was studied in the Southern Caspian Sea using the "shiftogram" method on available fisheries-related (i.e. commercially important bentho-pelagic fish stocks) ecological and climatic variables. As indicators of potential environmentally driven shift patterns we used indices for the North Atlantic Oscillation, the Southern Oscillation, the Siberian High, the East Atlantic-West Russia pattern, as well as Sea Surface Temperature and surface chlorophyll-a concentration. Given the explorative findings from the serial shift analyses, the cascading and se...
1785122195
Enhancing Tumor Drug Distribution With Ultrasound-Triggered Nanobubbles
Journal of Pharmaceutical Sciences, 2019
Issues with limited intratumoral drug penetration and heterogeneous drug distribution continue to impede the therapeutic efficacy of nanomedicine-based delivery systems. Ultrasound (US)-enhanced drug delivery has emerged as one effective means of overcoming these challenges. Acoustic cavitation in the presence of nanoparticles has shown to increase the cellular uptake and distribution of chemotherapeutic agents in vivo. In this study, we investigated the potential of a drug-loaded echogenic nanoscale bubbles in combination with low frequency (3 MHz), high energy (2 W/cm2) US for antitumor therapy. The doxorubicin-loaded nanobubbles (Dox-NBs) stabilized with an interpenetrating polymer mesh were 171.5 ± 20.9 nm in diameter. When used in combination with ther...
1785122194
Effects of oscillations and energy-driven fluctuations on the dynamics of enzyme catalysis and free-energy transduction
Phys. Rev. A, 1989
It has been shown that many enzymes should be capable of utilizing free energy supplied by external time-dependent perturbations to drive the chemical or transport reactions they catalyze away from equilibrium. This property is analyzed in terms of thermodynamic and kinetic theory. An explicit demonstration using irreversible thermodynamics, through second order, is given for the case of a simple model enzyme in the presence of a periodic external perturbation. Three reasons for an enzyme to drive a reaction in a nonstationary environment may be identified: the average values of the forces, the root mean square of the external time-dependent perturbation, and the frequency-dependent correlation between the applied perturbation and the enzyme response. The ex...
1785122194
Rotary Oscillations of Spheroids and Disks in an Elastico‐Viscous Fluid
Z Angew Math Mech, 1974
Es wird eine Theorie für die Strömung einer elastoviskosen Flüssigkeit aufgestellt, in der ein axialsymmetrischer Körper Drehschwingungen ausführt. Ziel ist die Behandlung des Scheiben-Elastoviskosimeters. Zu diesem Zweck Lösen wir die Randwertaufgabe für Rotationsellipsoide und leiten daraus durch Grenzübergang die Lösung für die Scheibe her. Es werden die Werte sowohl der Geschwindigkeit im Strömungsfeld als auch des Drehmoments, das die umströmten Körper erleiden, abgeleitet. The theory is developed for the flow of an elastico-viscous fluid when an axially symmetric body executes rotary oscillations in it. Our aim is to discuss the disk elastico-viscometer. For this purpose we solve the boundary value problems for the spheroids and derive the...
1785122194
Revaluation of the aging property modification factor of lead rubber bearings based on accelerated aging tests and finite element analysis
Nuclear Engineering and Design, 2019
The hysteresis characteristics of lead rubber bearings (LRBs) are affected by external temperature and aged-related degradation, among other things. The American Association of State Highway and Transportation Officials (AASHTO) presents an aging property modification factor (λaging) according to the type of seismic isolators in order to consider the change at design stage, of the age-related degradation characteristics of LRBs. However, the aging property modification factor is affected by the diameter of a bearing and the aging time as well as the type of seismic isolators. In this study, the time dependent properties of rubber materials were defined based on the results of an accelerated aging test, and the critical aging depth of the LRBs was calculated...
1785122194
Management of severe traumatic brain injury (first 24 hours)
Anaesthesia Critical Care & Pain Medicine, 2018
The latest French Guidelines for the management in the first 24hours of patients with severe traumatic brain injury (TBI) were published in 1998. Due to recent changes (intracerebral monitoring, cerebral perfusion pressure management, treatment of raised intracranial pressure), an update was required. Our objective has been to specify the significant developments since 1998. These guidelines were conducted by a group of experts for the French Society of Anesthesia and Intensive Care Medicine (Société francaise d'anesthésie et de réanimation [SFAR]) in partnership with the Association de neuro-anesthésie-réanimation de langue française (ANARLF), The French Society of Emergency Medicine (Société française de médecine d'urgence (SFMU), the Société ...
1785122194
A Methodological Review of Extraction, Purification, and Identification Techniques for Natural Bioactive Compounds
Org. Process Res. Dev., 2025
Natural resources, both land and sea, contain many bioactive compounds. Today, these compounds have attracted the attention of many researchers due to their many therapeutic, medical, and other industrial applications. Due to their important health effects, extracting, purifying, and identifying the properties and structural descriptions of natural compounds show great attention in their analytical science. A crucial initial step in generating high-quality research results is preparing medicinal plants for testing. Prior to performing the intended biological test, biologically active chemicals must be extracted, purified, and their concentration and purity determined. Examples of popular extraction methods include percolation, Soxhlet, maceration, ultrasonic...
1785122194
Efficient Registration of Intraoral Point Clouds Using 3-D Spatial Consistent Grouping Method With Global Optimization
IEEE Trans. Instrum. Meas., 2025
Intraoral 3-D scanning is a vital component of modern oral therapy. Because of the limited field of view (FOV) and degraded image quality of the intraoral scanner, matching the bundle of the intraoral dense point clouds with a low signal-to-noise ratio (SNR) in real time (approximately 25 point clouds per second) is challenging; consequently, the accuracy of the reconstructed full arch gets degraded. This study proposes an innovative matching method for intraoral point clouds with high efficiency, which involves a 3-D spatial consistent grouping (3D-SCG) method in the intraoral scanning scheme. First, the method introduces the Tooth-Net module, which is a multilayer neural network based on the attention mechanism, to achieve high-dimensional geometric featur...
1785122194
FoxQ1 Promotes Glioma Cells Proliferation and Migration by Regulating NRXN3 Expression
PLoS ONE, 2013
Background Forkhead box Q1 (FoxQ1) is a member of the forkhead transcription factor family, and it has recently been found to participate in cancer development. However, whether FoxQ1 expression contributes to glioma development and progression is not known. We investigate FoxQ1 expression in gliomas and the role of FoxQ1 during tumorgenesis. Methods Reverse transcription quantitative real-time PCR (RT-qPCR) and Western blot were used to determine the FoxQ1 and Neurexins 3 (NRXN3) expression in gliomas. Chromatin immunoprecipitation (ChIP) and luciferase assays were used to determine the regulation between FoxQ1 and NRXN3. We established depleted FoxQ1 stable clones in U-87MG cells and overexpressed FoxQ1 stable clones in SW1088 cells. MTT and transwell were...
1785122193
Infrared Irradiation Drying Impact on Bee Pollen: Case Study on the Phenolic Composition of Eucalyptus globulus Labill and Salix atrocinerea Brot. Pollens
Processes, 2021
Bee pollen is commonly reputed as a rich source of nutrients, both for bees and humans. Its composition is well balanced and can be taken as a stand-alone food or as supplement, including for the elderly owing its low caloric value. However, storage conditions frequently lead to product degradation, namely due to the high moisture content that enable the proliferation of molds and bacteria. Herein, an infrared (IR)-based technology is proposed as a mean to determine moisture content, setting also a new scalable approach for the development of a drying technology to be used for bee pollen processing, which can be carried out in a short time, without impacting the phenolic and flavonoid content and associated bioactive effects. Proof-of-concept was attained wi...
1785122193
Left Atrial Morphology and Function
Circ: Cardiovascular Imaging, 2016
In the prediction of the risk of cardiovascular events, the role of the left ventricle (LV) has been established for a long time, in the general population and especially in patients with heart failure. LV dimensions and systolic function, the latter mainly expressed as ejection fraction, were the first variables investigated; over the years, the role of predictors of cardiovascular outcomes has been extended to an increased LV mass (ie, hypertrophy) and altered chamber geometry, to an increase in stiffness and parallel reduction in filling properties (diastolic dysfunction), and more recently, to subclinical alterations of systolic function (myocardial strain and strain rate), in an attempt to identify predictors of risk at an early stage of dysfunction, wh...
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Severe Meprobamate Intoxication: In Death as in Life?
Canadian Society of Forensic Science Journal, 1996
An unusual case is presented where a toxicological investigation conducted in one laboratory was important for the proper interpretation of postmortem toxicology findings in the same person, in a different laboratory, seven months later. The first incident, a minor motor vehicle accident, involved a severe meprobamate intoxication in which the person's blood concentration was 98 mg/L. In the second incident, a fatal house fire, the postmortem blood meprobamate concentration was 96 mg/L. Knowledge of the first toxicological investigation and circumstances surrounding the matter aided interpretation of the postmortem toxicology findings: that the very high blood meprobamate concentrations probably resulted from chronic abuse of the drug and not from a suicidal...
1785122193
Stability and Local Unfolding of SOD1 in the Presence of Protein Crowders
J. Phys. Chem. B, 2019
Using NMR and Monte Carlo (MC) methods, we investigate the stability and dynamics of superoxide dismutase 1 (SOD1) in homogeneous crowding environments, where either bovine pancreatic trypsin inhibitor (BPTI) or the B1 domain of streptococcal protein G (PGB1) serves as a crowding agent. By NMR, we show that both crowders, and especially BPTI, cause a drastic loss in the overall stability of SOD1 in its apo monomeric form. Additionally, we determine chemical shift perturbations indicating that SOD1 interacts with the crowder proteins in a residue-specific manner that further depends on the identity of the crowding protein. Furthermore, the specificity of SOD1–crowder interactions is reciprocal: chemical shift perturbations on BPTI and PGB1 identify regions ...
1785122192
Ketogenic Diets Alter the Gut Microbiome Resulting in Decreased Intestinal Th17 Cells
Cell, 2020
Summary Very low-carbohydrate, high-fat ketogenic diets (KDs) induce a pronounced shift in metabolic fuel utilization that elevates circulating ketone bodies; however, the consequences of these compounds for host-microbiome interactions remain unknown. Here, we show that KDs alter the human and mouse gut microbiota in a manner distinct from high-fat diets (HFDs). Metagenomic and metabolomic analyses of stool samples from an 8-week inpatient study revealed marked shifts in gut microbial community structure and function during the KD. Gradient diet experiments in mice confirmed the unique impact of KDs relative to HFDs with a reproducible depletion of bifidobacteria. In vitro and in vivo experiments showed that ketone bodies selectively ...
1785122192
Laser Surface Treatment of Sintered Stainless Steels for Wear Resistance Enhancement
KEM, 2019
In the present study, sintered austenitic stainless steel type 316L was laser surface alloyed with Inconel 625 powder by the fibre optic laser. The Inconel 625 spheroidal powder of grain size 60-150 μm was introduced by the coaxial feeding head directly to the liquid metal, during laser surface alloying. The process parameters were selected to melt and fully dissolve alloying powder into the alloyed surface. As a result of laser alloying, the porosity of sintered stainless steel was eliminated, a uniform distribution of nickel and molybdenum in the entire alloyed zone was obtained. The alloyed surface shows fully austenitic microstructure of 17%Cr, 18%Ni, 3%Mo. The superficial hardness, microhardness and surface wear resistance were significantly improved i...
1785122192
Pediatric Somatic Tumor Sequencing Identifies Underlying Cancer Predisposition
JCO Precision Oncology, 2019
PURPOSE The diagnosis of cancer predisposition in pediatric patients with cancer is vital for treatment decisions, surveillance, and management of at-risk family members. Somatic tumor testing can identify potential underlying constitutional variants that confer increased cancer risk. Here, we report the characteristics of constitutional variants identified through tumor testing. MATERIALS AND METHODS Data were abstracted from medical record review of 1,023 patients who received in-house somatic tumor testing over a 28-month period. Patients were identified for testing using referral criteria developed as a collaboration between genomic diagnostics, pathology, and oncology. Characteristics of patients who underwent constitutional testing, including family hi...
1785122192
Atomic Structure and Dynamics of Epitaxial Platinum Bilayers on Graphene
ACS Nano, 2019
Platinum atomic layers grown on graphene were investigated by atomic resolution transmission electron microscopy (TEM). These TEM images reveal the epitaxial relationship between the atomically thin platinum layers and graphene, with two optimal epitaxies observed. The energetics of these epitaxies influences the grain structure of the platinum film, facilitating grain growth via in-plane rotation and assimilation of neighbor grains, rather than grain coarsening from the movement of grain boundaries. This growth process was enabled due to the availability of several possible low-energy intermediate states for the rotating grains, the Pt-Gr epitaxies, which are minima in surface energy, and coincident site lattice grain boundaries, which are minima in grain b...
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Short ballistic Josephson coupling in micrometer-long tantalum/graphene/tantalum junction
Current Applied Physics, 2019
Abstract Enhancing the Josephson coupling strength inside superconductor-normal-superconductor junctions facilitates the versatile applications of Josephson devices. We adopted DC magnetron sputtered tantalum film for the superconducting contact of graphene Josephson junction which resulted in reinforcing the superconducting correlation. The transport properties of the micrometer scale graphene Josephson junctions both in normal and superconducting states are investigated. The strong Josephson coupling is manifested by two transport characteristics of Josephson junction. First, the I C R N product in scale of superconducting gap energy approaches to 2, which is close to the theoretical prediction for the Josephson junction in short and ballistic regime. Seco...
1785122192
Information Geometric Approach to Multisensor Estimation Fusion
IEEE Trans. Signal Process., 2019
Distributed estimation fusion is concerned with the combination of local estimates from multiple distributed sensors to produce a fused result. In this paper, we characterize local estimates as posterior probability densities, and assume that they all belong to a parametric family. Our starting point is to consider this family as a Riemannian manifold by introducing the Fisher information metric. From the perspective of information geometry, the fused density is formulated as an informative barycenter in the space of probability densities and sought by minimizing the sum of its squared geodesic distances from the local posterior densities. Under Gaussian assumptions, a geodesic projection (GP) method and a Siegel distance (SD) method in the information-geome...
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VP15.06: Peripheral chemoreflex and cardiac function during acute hypoxemia and metabolic acidosis without placental compromise in late‐term sheep fetuses
Ultrasound in Obstet & Gyne, 2020
Hypoxia activates fetal chemoreflex which aids to redistribute blood flow to brain, myocardium and adrenal glands. We wanted to examine the chemoreflex activation and cardiac function in term gestation with a sheep model without manipulating umbilical blood flow. At GA 115-128/145, a vascular catheter was placed either in the carotid artery (n = 10) or in the descending aorta (n = 7). After a 4-day recovery period, baseline measurements were performed. Maternal hypo-oxygenation was induced, after which the measurements were repeated at 10 min (Acute hypoxemia) and at 60 min (prolonged hypoxemia). Fetal cardiac function and peripheral hemodynamics were assessed with Doppler ultrasound at each phase, and invasive blood pressures (BP) and arterial blood samples...
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The evolutionary process of Medical Emergency Team (MET) implementation: reduction in unanticipated ICU transfers
Resuscitation, 2001
To determine whether the introduction of the Medical Emergency Team (MET) system designed to provide immediate help for seriously ill patients: (i) changed the pattern of ICU patient transfers from the wards; and (ii) improved hospital survival rates.Prospective information on MET calls and unanticipated ICU transfers was collected for 3 years in a suburban metropolitan hospital.A 3-year review of MET showed the number of MET calls doubled in the second and third year and the team was activated for more than just the most extremely ill patients. Whilst the frequency of calls for cardiopulmonary arrest remained constant (n = 16), increased use of the MET resulted in the proportion of calls for cardiopulmonary arrest dropping from 30% in year 1 to 13% in year ...
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Coseismic hydrological changes associated with dislocation of the September 21, 1999 Chichi earthquake, Taiwan
Geophysical Research Letters, 2002
[1] Being situated in the immediate vicinity of the 1999 Chichi earthquake epicenter, 178 automatic-recording monitoring wells of the Choshui fan-delta provided a very valuable data set for testing whether the coseismic water-level changes in confined aquifers can be explained as a poroelastic response of well-aquifer systems to coseismic volumetric strain. This study demonstrates that the polarities of the observed coseismic water-level and river discharge changes are in good agreement with those of the static volumetric strain calculated by a dislocation model, using the well-constrained rupture model of the seismogenic Chelungpu fault. The puzzling “bull-eye” patterns formed by the equipotential lines of the coseismic water-level changes in the confi...
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Dynamin-Catalyzed Membrane Fission Requires Coordinated GTP Hydrolysis
PLoS ONE, 2013
Dynamin is the most-studied membrane fission machinery and has served as a paradigm for studies of other fission GTPases; however, several critical questions regarding its function remain unresolved. In particular, because most dynamin GTPase domain mutants studied to date equally impair both basal and assembly-stimulated GTPase activities, it has been difficult to distinguish their respective roles in clathrin-mediated endocytosis (CME) or in dynamin catalyzed membrane fission. Here we compared a new dynamin mutant, Q40E, which is selectively impaired in assembly-stimulated GTPase activity with S45N, a GTP-binding mutant equally defective in both basal and assembly-stimulated GTPase activities. Both mutants potently inhibit CME and effectively recruit other...
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Reciprocal enhancement of gene expression between the phz and prn operon in Pseudomonas chlororaphis G05
J Basic Microbiol, 2018
In previous studies with Pseudomonas chlororaphis G05, two operons (phzABCDEFG and prnABCD) were confirmed to respectively encode enzymes for biosynthesis of phenazine-1-carboxylic acid and pyrrolnitrin that mainly contributed to suppression of some fungal phytopathogens. Although some regulators were identified to govern their expression, it is not known how two operons coordinately interact. By constructing the phz- or/and prn- deletion mutants, we found that in comparison with the wild-type strain G05, phenazine-1-carboxylic acid production in the mutant G05Δprn obviously decreased in GA broth in the absence of prn, and pyrrolnitrin production in the mutant G05Δphz remarkably declined in the absence of phz. By generating the phzA and prnA transcriptiona...
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Pip serves as an intermediate in RpoS-modulated phz2 expression and pyocyanin production in Pseudomonas aeruginosa
Microbial Pathogenesis, 2020
Pyocyanin, a main virulence factor that is produced by Pseudomonas aeruginosa, plays an important role in pathogen-host interaction during infection. Two copies of phenazine-biosynthetic operons on genome, phz1 (phzA1B1C1D1E1F1G1) and phz2 (phzA2B2C2D2E2F2G2), contribute to phenazine biosynthesis. In our previous study, we found that RpoS positively regulates expression of the phz2 operon and pyocyanin biosynthesis in P. aeruginosa PAO1. In this work, when a TetR-family regulator gene, pip, was knocked out, we found that pyocyanin production was dramatically reduced, indicating that Pip positively regulates pyocyanin biosynthesis. With further phenazines quantification and β-galactosidase assay, we confirmed that Pip positively regulates phz2 expression, bu...
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Ab initio potential energy surface and rotationally inelastic collisions of LiH (X1$Sigma;+) with H. I. The ab initio evaluation of the potential energy surface
Journal of Molecular Structure: THEOCHEM, 2004
In this work we present a study of the interaction between the hydrogen atom and the LiH (X1Σ+) molecule. The potential energy surface describing this interaction has been calculated very accurately for a fixed distance, that is the equilibrium distance of the LiH molecule and for a wide range of orientations and distances between the hydrogen atom and the center of mass of the LiH target system. The H–LiH system has been reduced to a system of only three electrons, those of valence, by replacing Li+ (1s2) by a pseudopotential. A large configuration interaction (CI) has been performed. The potential energy curves in terms of Jacobi coordinates V(re=3.014a.u., R, γ), show the strong anisotropy of interaction potential. We note the presence of a double wel...
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A Novel Navigation Device for Precise Percutaneous Placement of the Guidewire in Femoral Neck Fracture Cannulated Screw Fixation Surgery
IEEE J. Transl. Eng. Health Med., 2024
The accuracy of screw placement is a key factor for the stability of the cannulated screws used in the fixation of femoral neck fractures. In this study we designed a navigation device for ensuring the screw reaches the ideal position for optimal fixation. From March 2019 to September 2020, 66 patients with femoral neck fracture were enrolled and divided into 2 groups, one group was treated using the traditional free-hand cannulated screw fixation and the other using the new navigation device with assisted fixation. The effectiveness of the 2 methods was compared based on surgery duration, intraoperative bleeding, number of fluoroscopic examination and guidewire insertion attempts, screw parallelism, and effective fixation area. Fracture healing, complicatio...
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The Nuclear Tyrosine Kinase BRK/Sik Phosphorylates and Inhibits the RNA-binding Activities of the Sam68-like Mammalian Proteins SLM-1 and SLM-2
Journal of Biological Chemistry, 2004
Expression of the intracellular tyrosine kinase BRK/Sik is epithelial-specific and regulated during differentiation. Only a few substrates have been identified for BRK/Sik, including the KH domain containing RNA-binding protein Sam68 and the novel adaptor protein BKS. Although the physiological role of Sam68 is unknown, it has been shown to regulate mRNA transport, pre-mRNA splicing, and polyadenylation. Here we demonstrate that the Sam68-like mammalian proteins SLM-1 and SLM-2 but not the related KH domain containing heterogeneous nuclear ribonucleoprotein K are novel substrates of BRK/Sik. The expression of active BRK/Sik results in increased SLM-1 and SLM-2 phosphorylation and increased retention of BRK/Sik within the nucleus. The phosphorylation of SLM-1...
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Out-of-Plane Strength of Confined Masonry Walls
J. Struct. Eng., 2012
This paper presents the results of a study on the out-of-plane behavior of confined masonry walls. Six full-scale walls were tested in a laboratory under incremental uniform pressures. Walls with different aspect ratios, slenderness ratios, and in-plane stiffness of confining elements were considered. The spring-strut method was developed in this work to determine the out-of-plane strength of the walls. Experimental out-of-plane strengths are compared with those obtained with analytical models based on this spring-strut method, the yield line method, the failure line method, and the compressive strut method. Based on the experimental results, for walls with similar geometry, the out-plane strength depends mainly on the in-plane stiffness of the confining ele...
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Mutations in the glucocerebrosidase gene are common in patients with Parkinson's disease from Eastern Canada
International Journal of Neuroscience, 2015
Mutations in the β-glucocerebrosidase gene (GBA) have been implicated as a risk factor for Parkinson's disease (PD). However, GBA mutations in PD patients of different ethnic origins were reported to be inconsistent.We sequenced all exons of the GBA gene in 225 PD patients and 110 control individuals from Eastern Canada.Two novel GBA variants of c.-119 A/G and S(-35)N, five known GBA mutations of R120W, N370S, L444P, RecNciI and RecTL mutation (del55/D409H/RecNciI) as well as two non-pathological variants of E326K and T369M were identified from PD patients while only one mutation of S13L and two non-pathological variants of E326K and T369M were found in the control individuals. The frequency of GBA mutations within PD patients (4.4%) is 4.8 times higher tha...
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Structures of Pt clusters on graphene by first-principles calculations
Surface Science, 2010
The interactions between Ptn clusters (n⩽13) and a graphene sheet have been investigated by first-principles calculations based on density functional theory. For single Pt-atom and Pt2-dimer adsorptions, the stable adsorption sites are bridge sites between neighboring carbon atoms. When the number of Pt atoms in a cluster increases, the Pt–C interaction energy per contacting Pt atom becomes smaller. For smaller clusters (3⩽n⩽7), the adsorption as a vertical planar cluster is more stable than that as parallel planar or three-dimensional (3D) clusters, due to the stability of a planar configuration itself and the stronger planar-edge/graphene interaction, while the adsorption as a parallel planer cluster becomes stable for larger cluster (n⩾7) via th...
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Clinico-pathomorphological, serum biochemical and histological studies in broilers fed ochratoxin A and a toxin deactivator (Mycofix® Plus)
British Poultry Science, 2008
1. Toxic effects of two concentrations (0·5 and 1 mg/kg) of ochratoxin A (OTA) and attenuating effects of a toxin deactivator (Mycofix® PlusMTV INSIDE) containing the yeast Trichosporon mycotoxinivorans on the performance (feed conversion ratio; body weight gain), serum enzymes (lactate dehydrogenase, gamma-glutamyltranspeptidase and aspartate aminotransferase) and clinico-pathomorphology of internal organs were studied in 270 one-day-old broiler chicks divided into 9 groups over a 42-d period. 2. Feed conversion ratios (FCR) in groups fed toxin deactivator were improved compared with groups receiving OTA only. An increase in the relative weight of kidney and liver was observed in groups fed 0·5 and 1 mg/kg OTA on day 42 of the experiment as compared with...
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Topographical effects of transcutaneous electrical nerve stimulation on the H-reflex of the triceps surae muscles
Journal of Electromyography and Kinesiology, 1994
The present study was conducted on eight normal subjects in order to evaluate the effects of transcutaneous electrical nerve stimulation (TENS); 99 Hz, 250 μs pulse duration, applied over either the common peroneal (CPN) or sural nerve, on the H-reflex of the soleus (SO), gastrocnemius medialis (GM) and gastrocnemius lateralis (GL) muscles. Within each session, SO, GL and GM H-reflexes were recorded before (for 5 min), during (for 30 min) and after (for 10 min) TENS was applied at twice the sensory threshold for perception. It was found that, on average, while the stimulation was administered on the CPN: (a) the GL H-reflex amplitude increased by 40% (Friedman test: χ2 = 11.71, P < 0.05); (b) the SO H-reflex decreased (≥ 10% Hctrl), although not in a sta...
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Universele Rechten En Expliciete Principes
Bijdragen, 1997
Click to increase image sizeClick to decrease image sizeSummaryIts is argued that the point of the ideal of human rights is to protect individuals against oppressive regimes or cruel traditions. This negative description should not be converted into a positive one: it would be wrong to speak in terms of human rights about whatever people need in order to have meaningful lives. The reason why many philosophers are tempted to make that wrong move is that two kinds of individualism are easily conflated. The thesis that individuals should not be oppressed because of their choises or commitments is translated into the (very different) thesis freedom of individual choise should be maximized. The ideal of individual autonomy which manifests itself in the latter the...
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The characteristics and regularities of cardiac adverse drug reactions induced by Chinese materia medica: A bibliometric research and association rules analysis
Journal of Ethnopharmacology, 2020
Chinese materia medica (CMM) has been widely used as an approach of ethnomedicine worldwide. Recently, there are growing concerns related to the potential cardiotoxicity of herbal medicines but comprehensive studies are limited.Comprehensive literature retrieval via publicly available electronic databases was performed to identify the case reports that focused on cardiac adverse reactions (ADRs) triggered by oral CMMs. And a bibliometric survey was conducted to analyze the most commonly suspected risk factors in terms of responsible CMMs, susceptible patients and clinical administration of cardiac ADRs. Moreover, the techniques of data mining were utilized to investigate the regularities and association between the ADRs status and major contributory factors....
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Characterizing Nitrogen Sites in Nitrogen-Doped Reduced Graphene Oxide: A Combined Solid-State
15
N NMR, XPS, and DFT Approach
J. Phys. Chem. C, 2021
Despite the potential applications in energy storage and conversion systems such as Li–oxygen batteries and fuel cells, the nature and distribution of doped nitrogen sites in reduced graphene oxides are still not well understood. In this work, we report a combined approach of 15N solid-state nuclear magnetic resonance (NMR) spectroscopy alongside the predominantly used X-ray photoelectron spectroscopy (XPS) to characterize the nitrogen environments in reduced graphene oxides. Application of 1H–15N low-power double-quantum cross polarization under fast magic angle spinning with the Carr–Purcell–Meiboom–Gill scheme shows selective detection of protonated sites with low-power radio-frequency irradiation. NMR shift calculations of a series of N-contain...
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Living Arrangement and Loneliness Among Lesbian, Gay, and Bisexual Older Adults
GERONT, 2014
Loneliness is a key health risk for older adults. Utilizing the loneliness model, we examine the relationship between living arrangement and loneliness among lesbian, gay, and bisexual (LGB) older adults, taking into consideration potential correlates including social resources and personal constraints.We use data from a national survey of LGB adults aged 50 and older (N = 2,444). Types of living arrangement include living with a partner or spouse, living alone, and living with someone other than a partner or spouse.Compared with LGB older adults living with a partner or spouse, both those living alone and living with others reported higher degrees of loneliness, even after controlling for other correlates. The results of a multivariate regression analysis r...
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High Dietary Fat Intake Affects DNA Methylation/Hydroxymethylation in Mouse Heart: Epigenetic Hints for Obesity‐Related Cardiac Dysfunction
Molecular Nutrition Food Res, 2018
Scope Epigenetic aberrations caused by environmental factors and lifestyle choices have been associated with the development of a number of pathologies, including cardiovascular disorders. However, whether obesity-related heart dysfunction can occur via epigenetic mechanisms is largely undisclosed. The manifested role of DNA hydroxymethylation in heart pathophysiology prompts an investigation of its levels/machinery in heart of mice fed with high-fat diet (HFD) and its possible relation with genes linked to obesity-associated cardiac remodeling. Methods and results Alterations in levels of DNA methylation/hydroxymethylation modifications and in expression of Tet family of DNA hydroxylases are observed in hearts of mice treated with HFD for 8 and 16 weeks. De...
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Studies of the Thermal and Haline Influences on Growth and Survival of Litopenaeus vannamei and Litopenaeus setiferus
J World Aquaculture Soc, 2013
A series of experiments were conducted to examine the effects of salinity (1‐48g/L) on the biological performance, as evaluated by growth and survival, of the Pacific white shrimp, Litopenaeus vannamei, and the Atlantic white shrimp, Litopenaeus setiferus, reared at temperatures of 20, 24 or 28C. Poor growth and survival of L. vannamei was observed after 21‐28d of culture at low salinity (2 and 4g/L) at 20C. Raising salinity to 8 and up to 32g/L significantly increased survival at this temperature, indicating that avoiding low temperatures is critical for survival of this species when reared at low salinity. A major improvement in the growth rate of L. vannamei was observed at 24C, but it still was sub-optimal compared to growth observed at 28C. Irrespec...
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Explorative analysis of a score predicting the therapy response of patients with metastatic, castration resistant prostate cancer undergoing radioligand therapy with 177Lu-labeled prostate-specific membrane antigen
Ann Nucl Med, 2020
Abstract Objective Up to 60% of patients with metastatic, castration-resistant prostate cancer (mCRPC) treated with 177 Lu prostate-specific membrane antigen (PSMA) radioligand therapy (RLT) achieves a partial biochemical response with a decrease of > 50% in prostate-specific antigen (PSA) levels. The remaining fractions, however, do not respond to RLT. The aim of this explorative analysis was to identify pre-therapeutic factors for the prediction of response. Methods 46 patients [age = 68 years (50–87)] with mCRPC who consecutively underwent RLT with 177 Lu PSMA [median applied activity = 6 GBq (2.9–6.2)] were included and analysed retrospectively. The association of different clinical and laboratory factors and parameters from pre-therapeutic 68 Ga ...
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School Engagement: Potential of the Concept, State of the Evidence
Review of Educational Research, 2004
The concept of school engagement has attracted increasing attention as representing a possible antidote to declining academic motivation and achievement. Engagement is presumed to be malleable, responsive to contextual features, and amenable to environmental change. Researchers describe behavioral, emotional, and cognitive engagement and recommend studying engagement as a multifaceted construct. This article reviews definitions, measures, precursors, and outcomes of engagement; discusses limitations in the existing research; and suggests improvements. The authors conclude that, although much has been learned, the potential contribution of the concept of school engagement to research on student experience has yet to be realized. They call for richer character...
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Dual coding theory, word abstractness, and emotion: A critical review of Kousta et al. (2011).
Journal of Experimental Psychology: General, 2013
Kousta, Vigliocco, Del Campo, Vinson, and Andrews (2011) questioned the adequacy of dual coding theory and the context availability model as explanations of representational and processing differences between concrete and abstract words. They proposed an alternative approach that focuses on the role of emotional content in the processing of abstract concepts. Their dual coding critique is, however, based on impoverished and, in some respects, incorrect interpretations of the theory and its implications. This response corrects those gaps and misinterpretations and summarizes research findings that show predicted variations in the effects of dual coding variables in different tasks and contexts. Especially emphasized is an empirically supported dual coding the...
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Culture of the Japanese spiny lobster Panulirus japonicus from egg to juvenile stage.
NIPPON SUISAN GAKKAISHI, 1989
About 20, 0OO first stage phyllosomas were cultured at 24-28°C, being fed with nauplii of Artemia. Later stages were fed on Mytilus edulis ovary. Five phyllosomas reached stage VIII, approximately 200 days after hatching. Three phyllosomas reached stage XI and two individuals metamorphosed into pueruli 340-391 days (cf. 306 days for Jasus lalandii) after hatching. More than one molt was observed in several stages: 6 molts for stage VIII, 3 for IX and 3 for X. The intermolt interval was steady at 11-12 days throughout VIII-X, and slight morphological changes were observed at each molt. Stage VIII may be separated into 2 parts: early, consisting of 3 instars without pleopod buds, and advanced, consisting of 3 instars with pleopod buds. Number of stages should...
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Protection against Oxidative Stress in Beta Thalassemia/Hemoglobin E Erythrocytes by Inhibitors of Glutathione Efflux Transporters
PLoS ONE, 2013
In beta thalassemia/hemoglobin E (Hb E), abnormally high levels of oxidative stress account for accelerated senescence and increased destruction of erythrocytes. The present study aimed to investigate the role of glutathione efflux transporters, namely cystic fibrosis transmembrane conductance regulator (CFTR) and multidrug resistance-associated protein 1 (MRP1), in the control of glutathione levels and protection against oxidative challenges in beta thalassemia/Hb E erythrocytes. We found that CFTR protein was expressed in the erythrocytes of beta thalassemia/Hb E patients. Treatments with GlyH-101 (50 µM), a small molecule CFTR inhibitor, and MK571 (50 µM), an MRP1 inhibitor, reduced H2O2-induced free radical generation in the erythrocytes by ∼80% and ...
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Microelectrode recording can be a good adjunct in magnetic resonance image–directed subthalamic nucleus deep brain stimulation for parkinsonism
Surgical Neurology, 2006
The contribution of MER to improving bilateral STN-DBS is debatable. To resolve the controversy and elucidate the role of MER in DBS, we compared the outcome of bilateral STN-DBS surgery with and without MER in parkinsonian patients.From February 2002 to November 2002, the first 7 of 13 consecutive parkinsonian patients received STN-DBS without MER (group A), and the last 6 received STN-DBS with MER (group B). Pre- and postoperative assessments included scoring of UPDRS with video taping, and MR images.The mean Hoehn and Yahr stage was 3.6 in group A and 4.0 in group B. The mean follow-up was 7.4 months for group A and 5.3 months for group B. The mean coordinates of the tip of the permanent electrode relative to the mid-commissural point were x = 8.1 mm, y =...
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Sodium‐glucose co‐transporter (
SGLT
) and glucose transporter (
GLUT
) expression in the kidney of type 2 diabetic subjects
Diabetes Obesity Metabolism, 2017
The sodium-glucose co-transporters (SGLTs) are responsible for the tubular reabsorption of filtered glucose from the kidney into the bloodstream. The inhibition of SGLT2-mediated glucose reabsorption is a novel and highly effective strategy to alleviate hyperglycaemia in patients with type 2 diabetes mellitus (T2DM). However, the effectiveness of SGLT2 inhibitor therapy is diminished due, in part, to a compensatory increase in the maximum reabsorptive capacity (Tm) for glucose in patients with T2DM. We hypothesized that this increase in Tm could be explained by an increase in the tubular expression of SGLT and glucose transporters (GLUT) in these patients. To examine this, we obtained human kidney biopsy specimens from patients with or without T2DM and exami...
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Milk exosomes-mediated miR-31-5p delivery accelerates diabetic wound healing through promoting angiogenesis
Drug Delivery, 2022
The refractory diabetic wound has remained a worldwide challenge as one of the major health problems. The impaired angiogenesis phase during diabetic wound healing partly contributes to the pathological process. MicroRNA (miRNA) is an essential regulator of gene expression in crucial biological processes and is a promising nucleic acid drug in therapeutic fields of the diabetic wound. However, miRNA therapies have limitations due to lacking an effective delivery system. In the present study, we found a significant reduction of miR-31-5p expression in the full-thickness wounds of diabetic mice compared to normal mice. Further, miR-31-5p has been proven to promote the proliferation, migration, and angiogenesis of endothelial cells. Thus, we conceived the idea ...
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Hydrochemical, geophysical and multivariate statistical investigation of the seawater intrusion in the coastal aquifer at Phetchaburi Province, Thailand
Journal of Asian Earth Sciences, 2020
Abstract Seawater intrusion in coastal regions is an imperative ecological issues, and results in an undesirable consequence on future groundwater resources. To assess and mitigate seawater intrusion, the affected aquifers need to be characterized. By integrating geophysical investigation and multivariate statistical analysis of hydrochemical data, seawater intrusion into coastal aquifers at Cha-Am District in Phetchaburi Province (Thailand), as a model area that is adversely affected by this problem, was evaluated. The vertical electrical sounding (VES) survey study was conducted at 80 locations, and then 47 VES locations were used to create four pseudo cross-section lines in a west-east direction. The geophysical results were described together with the hy...
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A proteomic‐based investigation of potential copper‐responsive biomarkers: Proteins, conceptual networks, and metabolic pathways featuring Penicillium janthinellum from a heavy metal‐polluted ecological niche
MicrobiologyOpen, 2017
Filamentous fungi-copper (Cu) interactions are very important in the formation of natural ecosystems and the bioremediation of heavy metal pollution. However, important issues at the proteome level remain unclear. We compared six proteomes from Cu-resistant wild-type (WT) Penicillium janthinellum strain GXCR and a Cu-sensitive mutant (EC-6) under 0, 0.5, and 3 mmol/L Cu treatments using iTRAQ. A total of 495 known proteins were identified, and the following conclusions were drawn from the results: Cu tolerance depends on ATP generation and supply, which is relevant to glycolysis pathway activity; oxidative phosphorylation, the TCA cycle, gluconeogenesis, fatty acid synthesis, and metabolism are also affected by Cu; high Cu sensitivity is primarily due to an ...