1794518628
A transglycosylating chitinase from Chitiniphilus shinanonensis (CsChiL) hydrolyzes chitin in a processive manner
International Journal of Biological Macromolecules, 2020
Chitin, mostly extracted from shrimp waste, is the second most abundant biopolysaccharide, next only to cellulose. Enzymatic conversion of chitin into useful bioactive molecules such as chitooligosaccharides (COS) has potential biotechnological applications. The current study describes the characterization of a single modular GH18 chitinase from Chitiniphilus shinanonensis (CsChiL). CsChiL was optimally active at 50 °C in sodium citrate buffer, pH 6.0 and active over a broad pH range (6–10). In addition to hydrolysis, CsChiL displayed chitobiase and transglycosylation activities on COS with degree of polymerization (DP) 2 and 4–6, respectively. CsChiL hydrolyzed chitin polymers (α, β, and colloidal chitin) in a processive manner. Molecular dynamics si...
1794518628
MiR-92b regulates the cell growth, cisplatin chemosensitivity of A549 non small cell lung cancer cell line and target PTEN
Biochemical and Biophysical Research Communications, 2013
MicroRNAs (miRNAs) have emerged to play important roles in tumorigenesis and drug resistance of human cancer. Fewer studies were explored the roles of miR-92b on human lung cancer cell growth and resistance to cisplatin (CDDP). In this paper, we utilized real-time PCR to verify miR-92b was significantly up-regulated in non-small cell lung cancer (NSCLC) tissues compared to matched adjacent normal tissues. In vitro assay demonstrated that knock-down of miR-92b inhabits cell growth and sensitized the A549/CDDP cells to CDDP. Furthermore, we found miR-92b could directly target PTEN, a unique tumor suppressor gene, which was downregulated in lung cancer tissues compared to the matched adjacent normal tissues. These data indicate that the miR-92b play an oncogene...
1794518628
Strength, Modulus of Elasticity, and Brittleness Index of Rubberized Concrete
J. Mater. Civ. Eng., 2008
This paper presents a study of rubberized concretes designed by replacing coarse aggregate in normal concrete with ground and crushed scrap tire rubber in various volume ratios. The objective of the study was to investigate the effect of rubber types and rubber content on strength and deformation properties. The compressive strength, static, and dynamic modulus of elasticity of rubberized concrete were tested and studied. The stress-strain hysteresis loops were obtained by loading, unloading, and reloading on specimens. Brittleness index values were calculated based on the hysteretic loops. The experiments revealed that strength and modulus elasticity of rubberized concrete decreased with the increasing amount of rubber content. Compressive strength and modu...
1794518628
Quantitative Modeling of Complex Environments
International Journal of Intelligent Systems in Accounting, Finance and Management, 1993
There are many formal approaches to specifying how the mental state of an agent entails the particular actions it will perform. These approaches put the agent at the center of analysis. For some questions and purposes, it is more realistic and convenient for the center of analysis to be the task environment, domain or society of which agents will be a part. This paper presents such a task environment-oriented modeling framework that can work hand in hand with more agent-centered approaches. Our approach features careful attention to the quantitative computational interrelationships between tasks, to what information is available (and when) to update an agent's mental state and to the general structure of the task environment rather than single-instance examp...
1794518628
Synthesis, Crystal Structure, and Photophysical Properties of (1E,3E,5E)‐1,3,4,6‐Tetraarylhexa‐1,3,5‐trienes: A New Class of Fluorophores Exhibiting Aggregation‐Induced Emission
Chemistry An Asian Journal, 2009
Double Horner-Wadsworth-Emmons reaction of (E)-2,3-diaryl-1,4-bis(diethylphosphonyl)but-2-ene with (p-substituted) benzaldehydes gave (1E,3E,5E)-1,3,4,6-tetraarylhexa-1,3,5-trienes in moderate to good yields. Substitution of electron-withdrawing or -donating groups at the para position of the 1,6-diphenyl groups induced a slight bathochromic shift of UV spectra measured in CHCl(3) compared with that of the parent 1,3,4,6-tetraphenylhexa-1,3,5-triene. Although fluorescence was not observed with all the trienes in CHCl(3), they markedly emitted visible light in powder forms with quantum yields of 0.15-0.44. Introduction of amino groups at the para position of the 3,4-diphenyl groups induced a bathochromic shift of emission maxima with good solid-state quantum ...
1794518628
MOCVD growth of strained multiple quantum well structure for 1.3 μm InAsP/InP laser diodes
Solid-State Electronics, 1999
In this article, we describe the growth and characterization for 1.3 μm InAsP/InP strained multiple quantum well (SMQW) laser diodes (LDs) with separate confinement heterostructure grown at 580°C by metalorganic chemical vapor deposition. The grown strained single quantum well (SSQW) stack and strained multiple quantum well (SMQW) structures are characterized using double-crystal X-ray diffraction and photoluminescence (PL) to confirm the structural and optical qualities for practical device applications. The InAsP/InP SSQW stack grown at 580°C appears to be extremely abrupt, uniform, free of misfit dislocations and narrow PL half width. Although the InAsP/InP SMQWs grown at 580°C maintain its structural integrity throughout the deposition sequence, the ...
1794518628
Microwave‐Assisted Preparation of Semiconducting Polymers
Macromol. Rapid Commun., 2007
Polymeric semiconducting materials are being utilized as components in a new generation of electronic devices. The generation of high quality polymeric semiconductors often involves transition metal-catalyzed cross-coupling reactions, which require long reaction times. Microwave heating can be very efficient in reducing reaction times and consequently leads to increased reaction yields and concomitantly reduces the amount of side products. This microreview aims to summarize the use of microwave heating to prepare conjugated polymers, which are specifically tailored towards applications in optoelectronic and electronic devices. Moreover, microwave heating is a valuable investigative tool for the screening towards novel materials, especially when optimizing th...
1794518628
Ausência de desgaste agudo da musculatura esquelética e cardíaca em atletas amadores de triathlon
Rev. Bras. Cineantropom. Desempenho Hum., 2011
Creatine kinase (CK) and creatine kinase muscle-brain fraction (CK-MB) might be associated with damage to muscle and cardiac tissue, respectively, as a consequence of intense prolonged exercise. The objective of the present study was to determine whether acute changes in CK and CK-MB reflect some risk of damage to skeletal and cardiac muscles in amateur athletes after Ironman 70.3. The sample consisted of 10 male athlete volunteers (age: 34.0 ± 9.2 years). A venous blood sample (2 mL) was collected before and after the competition. The volunteers completed the race in 5h20min to 6 h. CK and CK-MB were analyzed by an enzymatic method using Wiener labreagent in an automatic spectrophotometer (Targa bt 3000). The nonparametric Wilcoxon test showed sig...
1794518628
Study of the formation process and the characteristics of tantalum layers electrodeposited on Nitinol plates in the 1-butyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide ionic liquid
Electrochimica Acta, 2013
Thanks to excellent mechanical and biochemical properties, the nickel–titanium shape memory alloy (Nitinol) constitutes an increasingly praised platform material in dental, cardiovascular and orthopedic biomedical devices. In order to strengthen their protective abilities toward corrosion, to reinforce their biocompatibility and to confer them specific osseointegrative capacities, Nitinol plates are covered with a thin tantalum layer by electrodeposition in the 1-butyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide ionic liquid. XPS and SEM/EDX analyses highlight the chemical and morphological characteristics of the deposits: notably, these present an intrinsic dimpled nanometric structuration which is particularly remarkable considering the “so...
1794518628
Microneedle-mediated intradermal delivery of 5-aminolevulinic acid: Potential for enhanced topical photodynamic therapy
Journal of Controlled Release, 2008
Photodynamic therapy of deep or nodular skin tumours is currently limited by the poor tissue penetration of the porphyrin precursor 5-aminolevulinic acid (ALA). In this study, silicon microneedle arrays were used, for the first time, to enhance skin penetration of ALA in vitro and in vivo. Puncturing excised murine skin with 6 x 7 arrays of microneedles 270 microm in height, with a diameter of 240 mum at the base and an interspacing of 750 microm led to a significant increase in transdermal delivery of ALA released from a bioadhesive patch containing 19 mg ALA cm(-2). Microneedle puncture enhanced ALA delivery to the upper regions of excised porcine skin but, at mean depths of 1.875 mm, ALA concentrations were similar to control values, possibly reflecting b...
1794518628
L’addiction au travail : quels effets de la charge de travail, de la dissonance émotionnelle et du surinvestissement ?
Pratiques Psychologiques, 2015
L’étude avait pour objectif d’évaluer l’addiction au travail au regard des exigences du travail (demande psychologique, effort, surinvestissement, dissonance émotionnelle) et des ressources liées au travail (latitude, soutien, récompense). Cette recherche a été conduite auprès de 342 conseillers en insertion professionnelle. Les résultats révèlent que les conseillers en insertion ont d’autant plus tendance à développer des comportements d’addiction au travail que le contexte de travail les expose à des demandes psychologiques élevées, à des efforts importants, à un surinvestissement et les place en situation de dissonance émotionnelle élevée et de faibles niveaux de soutien ainsi que de récompenses. La régression multiple met...
1794518628
Imitation and Innovation: The Dual Engines of Cultural Learning
Trends in Cognitive Sciences, 2015
Imitation and innovation work in tandem to support cultural learning in children and facilitate our capacity for cumulative culture. Here we propose an integrated theoretical account of how the unique demands of acquiring instrumental skills and cultural conventions provide insight into when children imitate, when they innovate, and to what degree. For instrumental learning, with an increase in experience, high fidelity imitation decreases and innovation increases. By contrast, for conventional learning, imitative fidelity stays high, regardless of experience, and innovation stays low. We synthesize cutting edge research on the development of imitative flexibility and innovation to provide insight into the social learning mechanisms underpinning the uniquely...
1794518628
Purification and Characterization of Laccase from Ceriporiopsis subvermispora
Asian J. Chem., 2014
Laccase from Ceriporiopsis subvermispora was purified and partially characterized using a combination of ammonium sulfate precipitation, DEAE-cellulose ion exchange chromatography and Sephadex G-100 molecular sieve column chromatography.The results demonstrated that the maximum laccase output from C. subvermispora fermentation reached 3900 U/L.The specific activity of the laccase increased from 10.28 U/mg in a crude enzyme solution to 245.27 U/mg after isolation and purification, with a purification factor of 23.86 and a yield of 24.40 %.The molecular mass of laccase was 63 kDa and the Michaelis-Menten constant value was 23.3 µmol/L.The optimal temperature for enzyme activity was 50 °C.The stabilization pH range was 4-5; within a pH 4-5 range, the relative...
1794518627
Altered error-related activity in patients with schizophrenia
Neuropsychologia, 2009
Deficits in working memory (WM) and executive cognitive control are core features of schizophrenia. However, findings regarding functional activation strengths are heterogeneous, partly due to differences in task demands and behavioral performance. Previous investigators proposed integrating these heterogeneous findings into a comprehensive model of cortical inefficiency assuming the inverted U-shaped relationship between performance and neuronal activation to be shifted in patients. The present study pursued a novel approach of precise performance balancing potentially resolving a number of discrepancies with regard to performance related cognitive activation patterns in schizophrenia. Error-related WM activity was examined in 55 patients and 55 controls by...
1794518627
Productivity Growth, On-the-Job Search, and Unemployment
SSRN Journal, 2011
This paper studies the impact of long-run productivity growth on job finding and separation rates, and thus the unemployment rate, using a search and matching model. We incorporate disembodied technological progress and on-the-job search into the endogenous job separation model of Mortensen and Pissarides (1994). Because we include on-the-job search, faster growth reduces unemployment by decreasing job separation and inducing job creation. The incorporation of on-the-job search substantially improves the ability of the Mortensen and Pissarides model to explain the effect of growth on labor market variables. Specifically, our model generates not only an empirically consistent sign of the effect, but also a larger impact of growth on unemployment than the stan...
1794518627
Bitstream syntax description: a tool for multimedia resource adaptation within MPEG-21
Signal Processing: Image Communication, 2003
Abstract In this paper, a generic method is described to allow the adaptation of different multimedia resources by a single, media resource-agnostic processor. This method is based on an XML description of the media resource's bitstream syntax, which can be transformed to reflect the desired adaptation and then be used to generate an adapted version of the bitstream. Based on this concept, two complementary technologies, BSDL 2 and gBS Schema, are presented. The two technologies provide solutions for parsing a bitstream to generate its XML description, for the generic structuring and marking of this description, and the generation of an adapted bitstream using its transformed description. The two technologies can be used as stand-alone tools; however, a join...
1794518627
Distinct µ-opioid ensembles trigger positive and negative fentanyl reinforcement
Nature, 2024
AbstractFentanyl is a powerful painkiller that elicits euphoria and positive reinforcement1. Fentanyl also leads to dependence, defined by the aversive withdrawal syndrome, which fuels negative reinforcement2,3 (that is, individuals retake the drug to avoid withdrawal). Positive and negative reinforcement maintain opioid consumption, which leads to addiction in one-fourth of users, the largest fraction for all addictive drugs4. Among the opioid receptors, µ-opioid receptors have a key role5, yet the induction loci of circuit adaptations that eventually lead to addiction remain unknown. Here we injected mice with fentanyl to acutely inhibit ...
1794518627
Withdrawal from extended‐access cocaine self‐administration results in dysregulated functional activity and altered locomotor activity in rats
Eur J of Neuroscience, 2013
Much work has focused on determining the consequences of cocaine self-administration on specific neurotransmitter systems, thus neglecting the global changes that occur. Previous imaging studies have focused on the effects of cocaine self-administration in the presence of high blood levels of cocaine, but have not determined the functional effects of cocaine self-administration after cocaine has cleared. Extended-access cocaine self-administration, where animals administer cocaine for 6 h each day, results in escalation in the rate of cocaine intake and is believed to model the transition from recreational use to addiction in humans. We aimed to determine the functional changes following acute (48 h) withdrawal from an extended-access, defined-intake self-ad...
1794518627
Observational studies: going beyond the boundaries of randomized controlled trials
Diabetes Research and Clinical Practice, 2010
The term observational study describes a wide range of study designs including prospective and retrospective cohort studies, case-control studies, and cross-sectional studies, a defining feature of which is that any intervention studied is determined by clinical practice and not the protocol. Data from large, prospective observational studies provide information about the safety and efficacy of medicines in daily clinical use. Such observational studies are generally carried out once a medicine has received approval from regulatory agencies. Observational trials have inherent limitations in terms of their susceptibility to bias and confounding, restricting their ability to define causality. However, their strengths include that they reflect daily clinical pr...
1794518627
Homocysteine levels and cancer risk in hypertensive adults across MTHFR C677T genotypes
Sci Rep, 2026
Metabolic factors, such as homocysteine (Hcy) metabolism, are believed to influence cancer risk. The MTHFR C677T polymorphism, which raises Hcy levels by affecting folate metabolism, has been associated with varying cancer risks. However, previous studies have not fully explored the interaction between Hcy levels and MTHFR C677T genotypes in relation to cancer risk. This nested case-control study within the China H-Type Hypertension Registry Study (CHHRS) included 1,219 cancer patients and 1,219 matched controls. Serum Hcy and MTHFR C677T genotypes were assessed, and odds ratios (ORs) with 95% confidence intervals (CIs) for cancer risk were calculated using conditional logistic regression. In univariate analyses, each standard deviation increase in Hcy was l...
1794518626
Akt2 Inhibition Enables the Forkhead Transcription Factor FoxO3a To Have a Repressive Role in Estrogen Receptor α Transcriptional Activity in Breast Cancer Cells
Molecular and Cellular Biology, 2010
Estrogen receptor alpha (ER) and the insulin-like growth factor I receptor (IGF-IR) pathways are engaged in a functional cross talk in breast cancer, promoting tumor progression and increased resistance to anticancer treatments and radiotherapy. Here, we introduce new mechanisms through which proteins of the IGF-I/IGF-IR signaling pathway may regulate ER function in the absence of ligand. Our results indicate that in ER-positive breast cancer cells, Akt2 modulates ER transcriptional activity at multiple levels, including (i) the regulation of ER expression and its nuclear retention and (ii) the activation of one of its downstream targets, the Forkhead transcription factor FoxO3a. FoxO3a colocalizes and coprecipitates with ER in the nucleus, where it binds to...
1794518626
Remove Organic and Inorganic Contaminants in the Waste Oil Using MBBR, Nano Reactor and Physical Methods
J Pet Environ Biotechnol, 2016
The aim of this study was to evaluate the performance of pilots physical, biochemical and chemical, in series and together for waste water treatment plants, processing oil in the Persian Gulf’s oil and gas. For this purpose a Skimmer tank, MBBR reactor, Nano reactor, UV tank was used. Incoming wastewater system effluent desalination unit. Hydraulic retention time for various different system is intended. If you reduce the retention time of 18 to 12 hours, removed COD from 91% to 76% reduced. It was also found that the total removal of carbon materials in part MBBR 78.2% and 21.8% of the biofilm floating microorganisms. The results indicate that the whole system, which consists of 4 pilot that each part of its eliminates COD in waste water, the ability to r...
1794518626
Sources of the adventitious microflora of a smear-ripened cheese
J Appl Microbiol, 2006
Aims: To determine the relationships between the major organisms from the cheese-making personnel and environment and the surface of a smear cheese. Methods and Results: 360 yeast and 593 bacteria from the cheese surface, the dairy environment and the hands and arms of personnel were collected. Pulsed-field gel electrophoresis, repetitive sequence-based polymerase chain reaction and 16S rDNA sequencing were used for typing and identifying the bacteria, and mitochondrial DNA restriction fragment length polymorphism and Fourier-transform infrared spectroscopy for typing and identifying the yeast. The three most dominant bacteria were Corynebacterium casei, Corynebacterium variabile and Staphylococcus saprophyticus, which were divided into three, five and seven...
1794518626
Anisotropic mechanical behavior and corresponding microstructure evolution of extruded AZ31 under combined normal/shear stress states
Materials Science and Engineering: A, 2019
In order to clarify the anisotropic mechanical behavior and corresponding microstructure evolution of extruded AZ31 Mg alloy under combined stress states, modified shear-tension specimens (STSs) and shear-compression specimens (SCSs) were specifically designed and tested by means of quasi-static uni-axial loading. The specimens with beveled opposed slots of different angles (0°, 15°, 30°, 45°, 60° and 75°) are used to obtain different τ/σn ratio (SN Ratio, τ/σn). With the SN Ratio increasing, different mechanical properties between STSs and SCSs are observed, i.e., equivalent yield strength and strain-hardening rate. These differences in deformation behavior are resulted from the activation stresses for twinning and slips. It is found that the defo...
1794518626
A multicentre epidemiological study on sunbed use and cutaneous melanoma in Europe
European Journal of Cancer, 2005
A large European case–control study investigated the association between sunbed use and cutaneous melanoma in an adult population aged between 18 and 49 years. Between 1999 and 2001 sun and sunbed exposure was recorded in 597 newly diagnosed melanoma cases and 622 controls in Belgium, France, The Netherlands, Sweden and the UK. Fifty three precent of cases and 57% of controls ever used sunbeds. The overall adjusted odds ratio (OR) associated with ever sunbed use was 0.90 (95% CI: 0.71–1.14). There was a South-to-North gradient with high prevalence of sunbed exposure in Northern Europe and lower prevalence in the South (prevalence of use in France 20%, OR: 1.19 (0.68–2.07) compared to Sweden, prevalence 83%, relative risk 0.62 (0.26–1.46)). Dose and l...
1794518626
Selective Glucose Isomerization to Fructose via a Nitrogen-doped Solid Base Catalyst Derived from Spent Coffee Grounds
ACS Sustainable Chem. Eng., 2018
In this work, glucose isomerization to fructose was conducted via a solid base biochar catalyst derived from spent coffee grounds and melamine. The X-ray photoelectron spectroscopy spectra identified the majority of pyridinic nitrogen on the biochar surface, which imparted the strong base character of the catalyst. Activity of the catalyst was evidenced by fast conversion of glucose (12%) and high selectivity to fructose (84%) in 20 min at a moderate temperature (120 °C) compared to recently reported immobilized tertiary amines at comparable N concentrations (10–15 mol % relative to glucose). By increasing the reaction temperature to 160 °C, fructose yield achieved 14% in 5 min. The base biochar catalyst showed superior selectivity (>80%) to commonly use...
1794518626
Comparison of self-citation by peer reviewers in a journal with single-blind peer review versus a journal with open peer review
Journal of Psychosomatic Research, 2015
Some peer reviewers may inappropriately, or coercively request that authors include references to the reviewers' own work. The objective of this study was to evaluate whether, compared to reviews for a journal with single-blind peer review, reviews for a journal with open peer review included (1) fewer self-citations; (2) a lower proportion of self-citations without a rationale; and (3) a lower ratio of proportions of citations without a rationale in self-citations versus citations to others' work.Peer reviews for published manuscripts submitted in 2012 to a single-blind peer review journal, the Journal of Psychosomatic Research, were previously evaluated (Thombs et al., 2015). These were compared to publically available peer reviews of manuscripts published...
1794518626
Effects of quarter individual and conventional milking systems on teat condition
Preventive Veterinary Medicine, 2014
An on-farm experiment was performed to investigate the effects of two milking systems on teat condition. An auto-tandem milking parlor made by GEA(®) with a conventional milking cluster (CON) and a single tube milking system called MultiLactor(®) (MULTI) from Siliconform GmbH were tested. For both milking system, in total 73 animals were milked over a period of seven months. To assess the effect of milking on teat condition, each teat was scored according to teat-condition evaluation systems. To evaluate teat condition, the teat color, ring formation at the teat base and formation of teat hyperkeratosis were assessed. The evaluation was conducted once a month after milking. The collected data were then statistically analyzed with generalized linear mixed m...
1794518626
Multiscale computational scheme for semi-analytical modeling of the point contact of inhomogeneous materials
International Journal of Solids and Structures, 2019
Semi-analytical models (SAMs) have been developed to analyze contact problems efficiently, including those of inhomogeneous materials, based on the equivalent inclusion method. However, understanding the behavior of microscopic inhomogeneities requires SAMs of even higher efficiency. This study builds a new semi-analytical model for high-speed simulations of contacts of materials containing distributed particles of sizes orders of magnitude smaller than that of the contact radius. The domain decomposition method is applied to construct a two-level mesh set to implement multiscale computation. The macroscopic mesh uses homogenized elements that ensure a high computing efficiency in obtaining the contact pressure distribution as a boundary condition, whereas t...
1794518625
Eine Megaselia‐Art (Dipt., Phoridae) als Parasit von Chilocorus quadrimaculatus Weise (Col., Coccinellidae) in Kenia
Zeitschrift für Angewandte Entomologie, 1972
Abstract Megaselia sp. (Dipt., Phoridae) as a parasite of Chilocorus quadrimaculatus Weise (Col., Coccinellidae) in Kenya. The ladybird C. quadrimaculatus is parasitized by a phorid of the genus Megaselia in the Kenya highlands (Nairobi). The larvae of the phorid penetrate the host's skin after hatching from the eggs which are deposited on the dorsal side of the larvae of the beetle. Pupation takes place 5–6 days later (at constant temperatures of 22–23° C) either near the anterior end of the dead larvae or around the pupae of the beetle. The pupal stage lasts 16–18 days. The pupae are parasitized by hyperparasitic Hymenoptera. Zusammenfassung Der Marienkäfer C. quadrimaculatus wird im Hochland von Kenia (Stadtgebiet von Nairobi) von einer Phoride de...
1794518625
Mitigating temozolomide resistance in glioblastoma via DNA damage-repair inhibition
J. R. Soc. Interface., 2020
Glioblastomas are among the most lethal cancers, with a 5 year survival rate below 25%. Temozolomide is typically used in glioblastoma treatment; however, the enzymes alkylpurine-DNA- N -glycosylase (APNG) and methylguanine-DNA-methyltransferase (MGMT) efficiently mediate the repair of DNA damage caused by temozolomide, reducing treatment efficacy. Consequently, APNG and MGMT inhibition has been proposed as a way of overcoming chemotherapy resistance. Here, we develop a mechanistic mathematical model that explicitly incorporates the effects of chemotherapy on tumour cells, including the processes of DNA damage induction, cell arrest and DNA repair. Our model is carefully parametrized and validated, and then used to virtually recreate the response of heterocl...
1794518625
White matter tracts associated with set-shifting in healthy aging
Neuropsychologia, 2009
Attentional set-shifting ability, commonly assessed with the Trail Making Test (TMT), decreases with increasing age in adults. Since set-shifting performance relies on activity in widespread brain regions, deterioration of the white matter tracts that connect these regions may underlie the age-related decrease in performance. We used an automated fiber tracking method to investigate the relationship between white matter integrity in several cortical association tracts and TMT performance in a sample of 24 healthy adults, 21–80 years. Diffusion tensor images were used to compute average fractional anisotropy (FA) for five cortical association tracts, the corpus callosum (CC), and the corticospinal tract (CST), which served as a control. Results showed that ...
1794518625
Genome-wide association study of the age of onset of childhood asthma
Journal of Allergy and Clinical Immunology, 2012
Childhood asthma is a complex disease with known heritability and phenotypic diversity. Although an earlier onset has been associated with more severe disease, there has been no genome-wide association study of the age of onset of asthma in children.We sought to identify genetic variants associated with earlier onset of childhood asthma.We conducted the first genome-wide association study of the age of onset of childhood asthma among participants in the Childhood Asthma Management Program (CAMP) and used 3 independent cohorts from North America, Costa Rica, and Sweden for replication.Two single nucleotide polymorphisms (SNPs) were associated with earlier onset of asthma in the combined analysis of CAMP and the replication cohorts: rs9815663 (Fisher P= 2.31 ...
1794518625
Thermal conductivity measurements of methane in the dense gaseous state
Physica, 1966
Abstract The thermal conductivity of methane has been measured at 1.9, 24.6, 43.6 and 75.1°C and pressures up to 580 atm with a coaxial cylindrical cell. For each of these temperatures, the thermal conductivity — reduced density relationships have been developed and have been used to establish the corresponding ( j ϱ R ) min values. These values have been utilized to calculate thermal conductivities predicted from the Enskog theory. The measured thermal conductivity values also have been used to produce the relationships of k - k ∗ versus ρ R and k - k ∗ versus ( ∂PR ∂TR ) ρR for methane. These relationships also include the thermal conductivity values of other investigators which were found in good agreement with the results of the present stu...
1794518625
Nitrosierung. Nitrosation: Von D. L. H. Williams. Cambridge University Press, Cambridge - New York - New Rochelle - Melbourne - Sydney 1988. 214 S., Abb., Tab., £ 27.50. ISRN 0-521-26796-X
Nachr. Chem. Tech. Lab., 1988
Nachrichten aus Chemie, Technik und LaboratoriumVolume 36, Issue 7 p. 762-763 Bücher Nitrosierung. Nitrosation: Von D. L. H. Williams. Cambridge University Press, Cambridge - New York - New Rochelle - Melbourne - Sydney 1988. 214 S., Abb., Tab., £ 27.50. ISRN 0-521-26796-X H. Meier, H. Meier MainzSearch for more papers by this author H. Meier, H. Meier MainzSearch for more papers by this author First published: Juli 1988 https://doi.org/10.1002/nadc.19880360718AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms...
1794518625
Hindered transport in fibrous membranes and gels: Effect of solute size and fiber configuration
Journal of Colloid and Interface Science, 1990
Hindered transport coefficients for a spherical macromolecule in a spatially periodic fibrous medium were calculated using two different methods. The first method is an effective medium approach based on Brinkman's equation and can be readily applied to disordered fibrous media. The second and more rigorous set of calculations makes use of generalized Taylor dispersion theory. Results from these two approaches are compared for two different spatially periodic lattices of bead-and-string fibers, which were chosen to illustrate the effects of inhomogeneity in the distribution of fibers. In addition, ratios of solute radius to fiber radius ranging from 0.5 to 5.0 were considered. Qualitative agreement between the two methods was obtained for each case studied, ...
1794518625
Theoretical systems of triboelectric nanogenerators
Nano Energy, 2015
Triboelectric nanogenerator (TENG) technology based on contact electrification and electrostatic induction is an emerging new mechanical energy harvesting technology with numerous advantages. The current area power density of TENGs has reached 313 W/m2 and their volume energy density has reached 490 kW/m3. In this review, we systematically analyzed the theoretical system of triboelectric nanogenerators. Starting from the physics of TENGs, we thoroughly discussed their fundamental working principle and simulation method. Then the intrinsic output characteristics, load characteristics, and optimization strategy is in-depth discussed. TENGs have inherent capacitive behavior and their governing equation is their V–Q–x relationship. There are two capacitance ...
1794518625
Fish-based biomonitoring to determine toxic characteristics of complex chemical mixtures: documentation of bioremediation at a pesticide disposal site
Aquatic Toxicology, 1991
Abstract Medaka ( Oryzias latipes ) embryo and larval short-term bioassays were used to rapidly demonstrate changes in toxicity of aqueous soil extracts at a pesticide disposal site before and after bioremediation. By chemical analysis, concentrations of most pesticides (particularly endosulfans) decreased after the 63-day bioremediation. In static larval assays of extracts before bioremediation, concentrations from 2.2 to 2.9% produced 50% larval mortality after 72 h exposure, whereas extract concentrations of 18 to 34% were required after remediation. Extract concentrations required to inhibit normal embryo development increased from 10% before bioremediation to 20% afterwards. Aqueous extracts from untreated soil were nonmutagenic (Ames bioassay) and, nin...
1794518625
Reservoir property changes during CO2–brine flow-through experiments in tight sandstone: Implications for CO2 enhanced oil recovery in the Triassic Chang 7 Member tight sandstone, Ordos Basin, China
Journal of Asian Earth Sciences, 2019
Abstract The effects of supercritical CO2 (ScCO2) on reservoir property changes of the Chang 7 Member tight sandstones of the Yanchang Formation, Ordos Basin, China, were investigated using CO2–brine flow-through experiments, in conjunction with detailed rock and fluid characterization (pre- and post-experiment) using X-ray diffraction mineral analysis, 3D computed tomography scanning, high-resolution scanning electron microscopy, and inductively coupled plasma–atomic emission spectrophotometry. An in situ 3D model was developed to define porosity–mineral evolution. Experiments on three contrasting samples show that minerals such as potassium (K) feldspar, albite, and calcite are variably dissolved during CO2–brine–mineral interactions. The dissolu...
1794518625
Heat‐cured concrete: Improving the early strength and pore structure by activating aluminosilicate internal curing agent with triisopropanolamine
J Am Ceram Soc, 2019
Although heat-cured concrete (HCC) has received extensive research interests in recent years, it still suffers from problems including coarsened microstructure, low cement hydration degrees, etc, which limited its application. Some of these problems can be solved by internal curing method resulting in low early strength of HCC and low-production efficiency. This study addressed this issue by activating the aluminosilicate internal curing agent (lightweight fine aggregate, LWFA) with triisopropanolamine (TIPA). The results indicated that more Al3+ and Fe3+ ions were dissolved from LWFA by TIPA, which assisted the formation of hydrates with cement ions in interfacial transition zone (ITZ), and enhanced the density of ITZ in the early stage. The introduction of...
1794518625
Future outlook for growth factors
Anti-Cancer Drugs, 1993
In the future improvements in the efficacy and safety profiles of the various growth factors in clinical use should be achievable through optimization of dosage schedules. The use of combinations of growth factors to provide hemopoietic support should enable considerable advances to be made in the treatment of hematological and non-hematological malignancies. Growth factors, such as granulocyte-macrophage colony stimulating factor may be used not only to maximize neutrophil recovery after myeloablative therapy, but also to mobilize peripheral blood stem cells prior to harvesting by leukapheresis. Growth inhibitory cytokines such as transforming growth factor-beta and macrophage inflammatory protein-1 alpha may be used to protect normal cells in the bone marr...
1794518625
Industrial method of cotton fabric finishing with chitosan–ZnO composite for anti-bacterial and thermal stability
Industrial Crops and Products, 2013
Abstract Chitosan–ZnO composites were prepared by hydrothermal method using commercial chitosan, 0.1 M zinc nitrate and 1.6 M sodium hydroxide. The advantage of this method is direct and a relatively easy ways of getting large amounts of chitosan–ZnO at lower temperature. Presence of chitosan was confirmed by FTIR spectroscopic analysis and crystalline structure of ZnO by XRD pattern. Photoluminescence spectra showed a yellow luminescence at ~620–630 nm and blue-violet emission at ~410–430 nm. TG/DTA analysis of the prepared chitosan–ZnO composites revealed higher thermal stability than commercial chitosan. SEM analysis shows that more number of chitosan–ZnO composite particles was dispersed within the micrometer scale. Antibacterial activity...
1794518624
VUV photoionization of Si(CH3)2Cl2 using synchrotron radiation
Chemical Physics Letters, 2004
The complicated dissociative photoionization of Si(CH3)2Cl2 has been investigated with photoionization mass spectrometry (PIMS) and a synchrotron as source of vacuum ultraviolet (VUV) radiation. We determined appearance energies (AE) of the parent cation Si(CH3)2Cl2+ and various ionic fragments -Si(CH3)2Cl+,Si(CH3)Cl2+,Si(CH3)Cl+, etc. – originating from photofragmentation. The appearance energy of Si(CH3)2Cl2+ is 10.41 eV, in agreement with measurements of the photoelectron spectrum. Relative photoexcitation spectra of individual fragment ion yields are obtained and the dissociative processes are discussed. A comparison of Si(CH3)2Cl2 and Si(CH3)Cl3 provides insight and understanding of fragmentation processes on dissociative photoionization of gaseous ch...
1794518624
The Impact of Mechanical and Restricted Kinematic Alignment on Knee Anatomy in Total Knee Arthroplasty
The Journal of Arthroplasty, 2017
Total knee arthroplasty (TKA), aiming at neutral mechanical alignment (MA), inevitably modifies the patient's native knee anatomy. Another option is kinematic alignment (KA), which aims to restore the original anatomy of the knee. The aim of this study was to evaluate the variations in lower limb anatomy of a patient population scheduled for TKA, and to assess the use of a restricted KA TKA protocol and compare the resulting anatomic modifications with the standard MA technique.A total of 4884 knee computed tomography scans were analyzed from a database of patients undergoing TKA with patient-specific instrumentation. The lateral distal femoral angle (LDFA), medial proximal tibial angle (MPTA), and hip-knee-ankle angle (HKA) were measured. Bone resections we...
1794518624
The Role of Community Engagement in Urban Innovation Towards the Co-Creation of Smart Sustainable Cities
J Knowl Econ, 2023
Abstract One of the most recent topics in smart cities is community engagement which has been generally deliberated in both industrial and academic literature around the approaches and tools employed in urban environment. Accordingly, the purpose of this study is to advocate for community engagement as a key driver that supports the acquisition of knowledge and requirements needed for innovation and creativity towards achieving an equitable community for social sustainability. A semi-systematic review method is adopted to analyze 71 sources from Web of Science and Scopus databases. Secondary data from the literature is extracted and synthesized to provide narrative and descriptive analysis. Findings from this study presents a developed model that can support...
1794518624
Detection of hypophosphite, phosphite, and orthophosphate in natural geothermal water by ion chromatography
Journal of Chromatography A, 2004
Current doctrine states that phosphorus is incorporated into cells in the pentavalent(V) oxidation state as orthophosphate. However, recent studies show that microorganisms contain enzymes used to metabolize reduced forms of phosphorous, including phosphite(III) and hypophosphite(I), which suggests that there is a natural source for these chemical species. This paper will discuss suppressed conductivity ion chromatography methods developed to detect hypophosphite, phosphite, and orthophosphate in a geothermal water matrix containing fluoride, chloride, bromide, nitrate, hydrogen carbonate and sulfate. All peaks were clearly resolved, and calibrations were linear with estimated 3σ detection limits of 0.83, 0.39, and 0.35 μM for hypophosphite, phosphite, and...
1794518624
Basal LAT-diacylglycerol-RasGRP1 Signals in T Cells Maintain TCRα Gene Expression
PLoS ONE, 2011
In contrast to the well-characterized T cell receptor (TCR) signaling pathways that induce genes that drive T cell development or polarization of naïve CD4 T cells into the diverse TH1, TH2, TH17 and Treg lineages, it is unclear what signals maintain specific gene expression in mature resting T cells. Resting T cells residing in peripheral lymphoid organs exhibit low-level constitutive signaling. Whereas tonic signals in B cells are known to be critical for survival, the roles of tonic signals in peripheral T cells are unknown. Here we demonstrate that constitutive signals in Jurkat T cell lines are transduced via the adapter molecule LAT and the Ras exchange factor RasGRP1 to maintain expression of TCRα mRNA and surface expression of the TCR/CD3 complex. ...
1794518624
Bayesian Neural Networks for Internet Traffic Classification
IEEE Trans. Neural Netw., 2007
Internet traffic identification is an important tool for network management. It allows operators to better predict future traffic matrices and demands, security personnel to detect anomalous behavior, and researchers to develop more realistic traffic models. We present here a traffic classifier that can achieve a high accuracy across a range of application types without any source or destination host-address or port information. We use supervised machine learning based on a Bayesian trained neural network. Though our technique uses training data with categories derived from packet content, training and testing were done using features derived from packet streams consisting of one or more packet headers. By providing classification without access to the conte...
1794518624
Rethinking the Alternatives: Food Sovereignty as a Prerequisite for Sustainable Food Security
Food ethics, 2023
AbstractThe concept of food sovereignty is primarily taken as an alternative to the prevailing neoliberal food security model. However, the approach has hitherto not received adequate attention from policy makers. This could be because the discourse is marked by controversies and contradictions, particularly regarding its ability to address the challenges of feeding a rapidly growing global population. In response to these criticisms, this paper argues that the principles of food sovereignty, such as democratic and transparent food systems, agroecology, and local market prioritization, should be fundamental pillars for achieving sustainable food security. It acknowledges that neither food sovereignty nor food security models ...
1794518624
Mycobacterium tuberculosis: 2014 Clinical Trials in Review
Canadian Journal of Infectious Diseases and Medical Microbiology, 2015
Tuberculosis (TB) is a major cause of death and suffering worldwide. Based on data from the WHO, an estimated nine million new cases were diagnosed in 2013, with 1.5 million associated deaths (1.1 million HIV-negative cases and 0.36 million HIV-positive cases) (1). Worldwide incidence and mortality rates have been declining over the past decade due to enhanced diagnosis and management of both TB and HIV infection. However, multidrug-resistant TB, which occurs in approximately 4% of cases, is challenging these advances (2). The past year witnessed the publication of several clinical trials surrounding TB management and control. In the present note, we briefly review and highlight clinical trials from the past year evaluating new diagnostic and therapeutic str...
1794518624
THE LICK-INDEX CALIBRATION OF THE GEMINI MULTI-OBJECT SPECTROGRAPHS
AJ, 2013
We present the calibration of the spectroscopic Lick/IDS standard line-index system for measurements obtained with the Gemini Multi-Object Spectrographs known as GMOS-North and GMOS- South. We provide linear correction functions for each of the 25 standard Lick line indices for the B600 grism and two instrumental setups, one with 0.5 arcsecond slit width and 1x1 CCD pixel binning (corresponding to ~2.5 Angstroem spectral resolution) and the other with 0.75 arcsecond slit width and 2x2 binning (~4 Angstroem). We find small and well-defined correction terms for the set of Balmer indices Hbeta, HgammaA, and HdeltaA along with the metallicity sensitive indices Fe5015, Fe5270, Fe5335, Fe5406, Mg2 and Mgb that are widely used for stellar population diagnostics of ...
1794518624
Association between TNF α Gene Polymorphisms and the Risk of Duodenal Ulcer: A Meta-Analysis
PLoS ONE, 2013
Epidemiological studies have evaluated the association between tumor necrosis factor α (TNF-α) single nucleotide polymorphisms (SNPs) and duodenal ulcer (DU), but the results remain inconclusive. The aim of this study was to perform a meta-analysis to investigate a more authentic association between TNF-α SNPs and DU.We performed the meta-analysis by searching PubMed, Embase, and Web of Science databases from the first available year to Sep. 5, 2012. Additionally, checking reference lists from identified articles, reviews, and the abstracts presented at related scientific societies meetings were also performed. All case-control studies investigating the association between TNF-α SNPs and DU risk were included. The association was assessed by odds ratio (...
1794518624
A light-responsive, self-immolative linker for controlled drug delivery via peptide- and protein-drug conjugates
Chem. Sci., 2019
When designing prodrugs, choosing an appropriate linker is the key to achieving efficient, controlled drug delivery. Herein, we report the use of a photocaged C4'-oxidized abasic site (PC4AP) as a light-responsive, self-immolative linker. Any amine- or hydroxyl-bearing drug can be loaded onto the linker via a carbamate or carbonate bond, and the linker is then conjugated to a carrier peptide or protein via an alkyl chain. The PC4AP linker is stable under physiologically relevant conditions. However, photodecaging of the linker generates an active intermediate that reacts intramolecularly with a primary amine (the ε-amine of a lysine residue and the N-terminal amine) on the carrier, leading to rapid and efficient release of the drug via an addition-eliminati...
1794518623
Human health risk assessment: selected internet and world wide web resources
Toxicology, 2002
The world wide web (WWW) has become a valuable source of 24 hour-a-day access to information needed by human health risk assessors. Various web sites and other Internet resources provide information needed for human hazard identification, dose-response evaluation, exposure assessment, risk characterization, and risk management. Information on risk communication is also available. Substantial collections of information on multiple aspects of risk assessment are found in sites sponsored by RiskWorld, the (US) EPA's National Center for Environmental Assessment (NCEA), the (US) National Library of Medicine's TOXNET, the (US) Agency for Toxic Substances and Disease Registry (ATSDR), and the International Programme on Chemical Safety (IPCS). Also valuable are vari...
1794518623
Subjective sleep disturbance and its correlates in middle-aged Hong Kong Chinese women
Maturitas, 2006
To examine the factors associated with subjective sleep disturbance in middle-aged Hong Kong Chinese women.A total of 305 women aged 45-55 years were recruited at community-based women's clubs. Eligible subjects were of Chinese ethnicity and not taking oral contraceptives, hormone therapy or had received surgical removal of ovary. Standardized questionnaires, including sociodemographic, health and life-style variables, Pittsburgh Sleep Quality Index (PSQI), Greene Climacteric Scale (GCS) and Perceived Stress Scale were administered.About 18% of the sample complained of difficulty initiating sleep, difficulty maintaining sleep or early morning awakening at least three times per week in the past month. About 26% of the women were poor sleepers as defined by a ...
1794518623
Synthesis and microstructure evolution during vacuum sintering of Mo2FeB2 based cermets
International Journal of Refractory Metals and Hard Materials, 2014
Mo2FeB2 based cermets were prepared by vacuum sintering at different temperatures and with different holding times. The phase transformation and microstructure evolution were studied by using scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDX) and X-ray diffraction analysis (XRD). It was found that the hard phase Mo2FeB2 was produced in the compact at the stage of solid phase sintering by the reaction Mo and Fe2B, which exhibited an equiaxed morphology. An extremely rapid densification occurred in the temperature ranging from 1050 °C to 1080 °C, and almost full densification was obtained at the temperature of 1080 °C without holding time. With an increase of liquid phase sintering temperature, the cermets exhibited a relatively homo...
1794518623
Estimation of manufacturing systems degradation rate for residual life prediction through dynamic workload adjustment
Sādhanā, 2019
Complex systems in a work cell often consist of multiple units to process the manufacturing functions effectively for achieving the desired objectives. All manufacturing work cells are familiar with many unforeseeable events, for instance machine down time and scheduled maintenance. In fact, every configuration naturally exhibits some level of redundancy during those unpredictable events that may fail a small portion of units. In this work, using the remaining units and by raising the workloads on these units, up to the level of their capacities, we tried to fulfil the requirement of products. To procure the requirement, dynamic workload adjustment strategy has been suggested on two important configurations such as parallel and hybrid, by actively controllin...
1794518623
Depression and Risk of Mortality in People with Diabetes Mellitus: A Systematic Review and Meta-Analysis
PLoS ONE, 2013
Objective To examine the association between depression and all-cause and cardiovascular mortality in people with diabetes by systematically reviewing the literature and carrying out a meta-analysis of relevant longitudinal studies. Research Design and Methods PUBMED and PSYCINFO were searched for articles assessing mortality risk associated with depression in diabetes up until August 16, 2012. The pooled hazard ratios were calculated using random-effects models. Results Sixteen studies met the inclusion criteria, which were pooled in an overall all-cause mortality estimate, and five in a cardiovascular mortality estimate. After adjustment for demographic variables and micro- and macrovascular complications, depression was associated with an increased risk o...
1794518623
Commentary
Clinics in Dermatology, 1993
To judge from the mounting number of publications during the past decade, there is enormous global interest in Lyme borreliosis, not only among the medical community but also among the public in general. This issue is a compilation of the current international knowledge of various aspects, mainly with clinical implications, of this tickborne infection, knowledge obtained by a multidisciplinary approach. Ongoing and future research may, however, alter or modify current views. Lyme borreliosis is a zoonotic disease with a wide distribution in the Northern Hemisphere. It is remarkable that although one of the clinical manifestations was recognized and described more than a century ago, it has only been about 10 years since the etiologic agent, Borrelia burgdorf...
1794518623
Protein packing in adsorbed layers studied by excitation energy transfer
Journal of Colloid and Interface Science, 1990
Abstract Excitation energy transfer (EET) from fluorescein donors attached to a bovine serum albumin molecule to tetramethylrhodamine acceptors attached to another albumin molecule in protein assemblies adsorbed on hydrophobized silica was measured by the total internal reflection fluorescence method as a quantity reflecting the arrangement of adsorbed proteins. There was no evidence of albumin aggregation during the growth of albumin-adsorbed layers. Layers obtained by adsorption from mixed albumin and immunoglobulin (IgG) solutions showed a random distribution of the protein molecules on the surface. A higher EET was observed if albumin was adsorbed from 1 mg/ml solution on a clean surface than if the surface was preexposed to low concentrated solutions be...
1794518623
Epithelial–mesenchymal transition and gastric cancer stem cell
Tumour Biol., 2017
Gastric cancer remains a big health problem in China. Gastric cancer cells contain a small subpopulation of cells that exhibit capabilities of differentiation and tumorigenicity. A putative explanation for ineffective therapy is the presence of cancer stem-like cells. Side population cells, which have cancer stem-like cells’ property, are characterized by the high efflux ability of Hoechst 33342 dye. Side population cells have been isolated from gastric cancer cell lines in previous studies. The epithelial–mesenchymal transition is very important in the invasion and metastasis of epithelial-derived cancers. More and more studies showed that gastric cancer stem-like cells possess high invasive ability and epithelial–mesenchymal transition property. A br...
1794518623
Application of cyclodextrin‐mediated capillary electrophoresis to determine the apparent binding constants and thermodynamic parameters of the alkylnaphthalene derivatives
Electrophoresis, 2005
The separation and migration behavior of seven positional and structural neutral alkylnaphthalene derivatives in cyclodextrin-mediated capillary electrophoresis were systematically investigated. The effective separation conditions were to use 10 mM phosphate buffer with negatively charged carboxymethyl-beta-cyclodextrin (CM-beta-CD) at pH 6.0. The guest-host interactions with 1:1 or both 1:1 and 1:2 binding stoichiometries for various derivatives were evaluated by comparing their apparent binding constants. The results reveal that the substituent group(s) attached to the naphthalene ring significantly affected the inclusion stoichiometric behaviors. Alkylnaphthalene derivatives with the substituent(s) at the 1-position(s), such as 1-ethylnaphthalene, 1,4-dim...
1794518623
Static and dynamic dilatation of the high-Tc superconductor EuBa2Cu3O7 − δHx
Journal of the Less Common Metals, 1991
Abstract Hydrogen induces an orthorhombic-to-tetragonal transformation in superconducting ceramics of the type RBa2Cu3O7. We have studied this transformation by measuring the thermal expansion coefficients of the system EuBa2Cu3O7Hx between liquid nitrogen and room temperature by X-ray diffractometry. For the hydrogen-free orthorhombic compound, the relative thermal expansion is approximately 50% stronger along b and c than along the a axis. Upon the addition of hydrogen, all thermal expansion coefficients decrease, with a strong drop near x = 0.5 (e.g. by more than a factor of four for a −1 Δa ΔT . The lattice parameters increase with x, with in general 1 a Δa Δx > 1 b Δb Δx > 1 c Δc Δx up to x ≈ 0.5, from whereon one observes coexistence of an ...
1794518623
Rhodium Catalyzed Regioselective C−H Allylation of Simple Arenes via C−C Bond Activation of Gem‐difluorinated Cyclopropanes
Angew Chem Int Ed, 2021
Herein, we report a rhodium catalyzed directing-group free regioselective C−H allylation of simple arenes. Readily available gem-difluorinated cyclopropanes can be employed as highly reactive allyl surrogates via a sequence of C−C and C−F bond activation, providing allyl arene derivatives in good yields with high regioselectivity under mild conditions. The robust methodology enables facile late-stage functionalization of complex bioactive molecules. The high efficiency of this reaction is also demonstrated by the high turnover number (TON, up to 1700) of the rhodium catalyst on gram-scale experiments. Preliminary success on kinetic resolution of this transformation is achieved, providing a promising access to enantio-enriched gem-difluorinated cyclopro...
1794518623
Holter monitoring in 36 dogs with myxomatous mitral valve disease
Aust Veterinary J, 2010
Objective Describe the presence of arrhythmias in dogs with myxomatous mitral valve disease (MMVD) and the potential association with class of heart failure and left atrial enlargement. Compare the standard electrocardiogram (ECG) with Holter monitoring for assessing heart rate (HR). Experimental procedure The study group of 36 dogs weighing less than 20 kg was divided into MMVD and no clinical signs (preclinical) or MMVD and clinical signs (clinical). A standard echocardiogram, ECG and 24-h Holter recording were obtained in all dogs. Results Minimum and mean Holter HRs were higher in the clinical group than in the preclinical group. Clinical dogs had more ventricular arrhythmias than preclinical dogs. An enlarged left atrium was associated with the presence...
1794518623
High loop rate adaptive optics flood illumination ophthalmoscope with structured illumination capability
Appl. Opt., 2018
The design and performance of an adaptive optics flood illumination ophthalmoscope (AO-FIO) platform, based on eye motion and dynamic aberrations experimental analysis, are described. The system incorporates a custom-built real-time controller, enabling up to 70 Hz loop rate without jitter, and an AO-corrected illumination capable of projecting high-resolution features in the retina. Wide-field (2.7°×5.4°) and distortionless images from vessel walls, capillaries, and the lamina cribrosa are obtained with an enhanced contrast and signal-to-noise ratio, thanks to careful control of AO parameters. The high spatial and temporal resolution (image acquisition up to 200 Hz) performance achieved by this platform enables the visuali...
1794518623
Global analysis of an SIS model with an infective vector on complex networks
Nonlinear Analysis: Real World Applications, 2012
In this paper, a modified SIS model with an infective vector on complex networks is proposed and analyzed, which incorporates some infectious diseases that are not only transmitted by a vector, but also spread by direct contacts between human beings. We treat direct human contacts as a social network and assume spatially homogeneous mixing between vector and human populations. By mathematical analysis, we obtain the basic reproduction number R0 and study the effects of various immunization schemes. For the network model, we prove that if R0
1794518623
Nanoporous Ni with High Surface Area for Potential Hydrogen Storage Application
Nanomaterials, 2018
Nanoporous metals with considerable specific surface areas and hierarchical pore structures exhibit promising applications in the field of hydrogen storage, electrocatalysis, and fuel cells. In this manuscript, a facile method is demonstrated for fabricating nanoporous Ni with a high surface area by using SiO2 aerogel as a template, i.e., electroless plating of Ni into an SiO2 aerogel template followed by removal of the template at moderate conditions. The effects of the prepared conditions, including the electroless plating time, temperature of the structure, and the magnetism of nanoporous Ni are investigated in detail. The resultant optimum nanoporous Ni with a special 3D flower-like structure exhibited a high specific surface area of about 120.5 m2/g. Th...
1794518623
Use of xanthan gum for whole cell immobilization and its impact in bioremediation - a review
Bioresource Technology, 2022
Xanthan gum is one of the exo-polysaccharides produced by bacteria and is characterized by unique non-Newtonian properties. Its structure and conformation strongly depend on the fermentation conditions and such factors as temperature and ions concentration. The properties of the xanthan gum were appreciated in the controlled drug delivery but in the crosslinked form. Due to its ability to enhance the survival rate of immobilized bacteria, the potential of a crosslinked form is promising. Unfortunately, xanthan gum crosslinking procedures often require toxic substances or harsh environmental conditions, which cannot be used in the entrapment of living cells. In this study, we summarised a crosslinking method that could potentially be modified to reduce its to...
1794518622
Minimum pressure gradient for foam flow in porous media: Effect of interactions with stationary lamellae
Journal of Colloid and Interface Science, 1990
As foam bubbles flowing through a porous medium at low pressure gradients pass trapped bubbles in adjacent pores, the moving lamellae interact with the stationary lamellae that separate the flowing from the trapped bubbles. These interactions distort the shapes of the flowing bubbles and thereby alter the capillary resistance to their flow. For incompressible foams at high capillary pressure, these interactions reduce the minimum pressure gradient required to maintain foam flow, (∇p)min; they may, in fact, reduce (∇p)min nearly to zero for these foams. We base this conclusion on a comparison of a two-dimensional (2-D) model for lamella shapes with observations of three-dimensional (3-D) lamellae in a model pore. The simplified 2-D model offers insights i...
1794518622
Effect of substrates on the structure of polymer interphases
Journal of Colloid and Interface Science, 1990
The molecular structure of the interphases formed when a model epoxy anhydride adhesive was cured against 2024 aluminum and copper was determined using X-ray photoelectron spectroscopy (XPS) and reflection—absorption infrared spectroscopy (RAIR). Adhesive joints were prepared by curing beams of epoxy against polished substrates at elevated temperatures. When the joints were immersed in liquid nitrogen, the residual stresses were sufficient to enable cracks to be propagated very near the interface, exposing the substrate and adhesive failure surfaces for analysis. Results obtained from XPS and RAIR showed that the anhydride curing agent reacted with the cuprous oxide (Cu 2 O) on the copper substrates. Cuprous ions were removed from the oxide and oxidized, r...
1794518622
Analgesic effect of sacroplasty in osteoporotic sacral fractures: A study of six cases
Joint Bone Spine, 2012
To evaluate the short-term analgesic effect of sacroplasty in patients with osteoporotic sacral fractures.Single-center retrospective observational study of all patients managed with sacroplasty for osteoporotic sacral fractures between October 2008 and November 2009. For each patient, symptom duration, pain intensity, and analgesic consumption were recorded. Sacroplasty was performed under local analgesia, in the prone position, with computed tomography guidance. The long-axis approach was sued to introduce the needles and polymethylmethacrylate cement along the fracture line(s). Pain was evaluated on a 10-point visual analog scale (VAS) 24 hours before sacroplasty then at the time of weight-bearing resumption 24 hours after the procedure. Hospital stay len...
1794518622
Development, characterization, and toxicity evaluation of amphotericin B–loaded gelatin nanoparticles
Nanomedicine: Nanotechnology, Biology and Medicine, 2008
Our aim in the present investigation was to develop a nanoparticulate carrier of amphotericin B (AmB) for controlled delivery as well as reduced toxicity. Nanoparticles of different gelatins (GNPs) (type A or B) were prepared by two-step desolvation method and optimized for temperature, pH, amount of cross-linker, and theoretical drug loading. AmB-loaded GNPs were characterized for size, polydispersity index (PI), shape, morphology, surface charge, drug release, and hemolysis. The developed GNPs (GNP(A300)) were found to be of nanometric size (213 +/- 10 nm), having low PI (0.092 +/- 0.015) and good entrapment efficiency (49.0 +/- 2.9%). All GNPs showed biphasic release characterized by an initial burst followed by controlled release. The in vivo hematologic...
1794518622
First experiences and perspectives for the use of cytokines in the treatment of non-Hodgkin??s lymphoma
Anti-Cancer Drugs, 1993
Log in or Register Subscribe to journalSubscribe Get new issue alertsGet alerts Submit your manuscript Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. For more information, please refer to our Privacy Policy. Subscribe to eTOC Secondary Logo Journal Logo All Articles Images Videos Podcasts Blogs Advanced Search Toggle navigation Subscribe Register Login Articles & Issues Current IssuePrevious IssuesPublished Ahead-of-Print For Authors Submit a ManuscriptInformation for AuthorsLanguage Editing ServicesAuthor Permissions Journal Info About the JournalEditorial BoardAdvertisingOpen AccessSubscr...
1794518622
Short- and long-term effects of early fosinopril administration in patients with acute anterior myocardial infarction undergoing intravenous thrombolysis: Results from the Fosinopril in Acute Myocardial Infarction Study
American Heart Journal, 1998
Background Angiotensin-converting enzyme inhibitors are used in patients who have myocardial infarction with left ventricular (LV) dysfunction. Few data are available in patients whose LV function is within the normal range. Methods and Results The Fosinopril in Acute Myocardial Infarction Study was a 2-year, randomized, double-blind, placebo-controlled, multicenter study of 285 patients with anterior acute myocardial infarction and was designed to investigate the effects of the early (
1794518622
Does repetitive Ritalin injection produce long-term effects on SD female adolescent rats?
Neuropharmacology, 2009
Methylphenidate (MPD), or Ritalin, is a psychostimulant that is prescribed for an extended period of time to children and adolescents with attention deficit hyperactivity disorder. Adolescence is a time of critical brain maturation and development, and the drug exposure during this time could lead to lasting changes in the brain that endure into the adulthood. Circadian rhythms are 24 h rhythms of physiological processes that are synchronized by the master-clock, the suprachiasmatic nucleus, to keep the body stable in a changing environment. The aim of present study is to observe the effect of repeated MPD exposure on the locomotor diurnal rhythm activity patterns of female adolescent Sprague–Dawley (SD) rats using the open field assay. 31 female adolescen...
1794518622
A disruption recovery plan in a three-stage production-inventory system
Computers & Operations Research, 2015
This paper proposes a recovery plan for managing disruptions in a three-stage production-inventory system under a mixed production environment. First, a mathematical model is developed to deal with a disruption at any stage while maximizing total profit during the recovery-time window. The model is solved after the occurrence of a disruption event, with changed data used to generate a revised plan. We also propose a new and efficient heuristic for solving the developed mathematical model. Second, multiple disruptions are considered, where a new disruption may or may not affect the recovery plans of earlier disruptions. The heuristic, developed for a single disruption, is extended to deal with a series of disruptions so that it can be implemented for disrupti...