1781933235
THE GENETIC PROGRAM OF GENITAL HUMAN PAPILLOMAVIRUSES IN INFECTION AND CANCER
Obstetrics and Gynecology Clinics of North America, 1996
Human papillomavirus (HPV) infection has been recognized as the major cause of cervical cancer. This article summarizes the functions of HPV gene products that cause abnormal cell growth--E6 and E7--and reviews how cellular and viral factors influence their synthesis. E6 and E7 inactivate two cellular tumor-suppressor gene products, p53 and RB. In cervical cancer, E6-E7 gene control is deranged by mutations in viral control sequences and in integrated HPV fragments by the disruption of the viral repressor E2. Elimination of this sequence makes E6-E7 mRNAs unstable, and deranges cellular regulation at the integration site. It is apparent that an intricate interplay of cellular and viral factors determines whether the outcome is active papillomavirus infection...
1781933235
The Influence of Centerline Segregation on the Mechanical Performance and Microstructure of X70 Pipeline Steel
steel research int., 2018
Centerline segregation is an inherent phenomenon during solidification. It is controlled by optimizing the continuous casting process, but is not easy to be avoided. According to the severity of centerline segregation of the slab, it affects the mechanical properties and final microstructure of rolled strip. The objective of this paper is to study the influence of centerline segregation degree on the microstructure and mechanical properties of X70 pipeline steels. In this study, the mechanical properties of strips produced from the slabs are examined and the results show that centerline segregation is some adverse effect on Charpy impact toughness and tensile properties of hot‐rolled strips. The strips from slab with higher degree of segregation, exhibits ...
1781933235
Inter‐viral conflicts that exploit host
CRISPR
immune systems of
S
ulfolobus
Molecular Microbiology, 2014
Infection of Sulfolobus islandicus REY15A with mixtures of different Sulfolobus viruses, including STSV2, did not induce spacer acquisition by the host CRISPR immune system. However, coinfection with the tailed fusiform viruses SMV1 and STSV2 generated hyperactive spacer acquisition in both CRISPR loci, exclusively from STSV2, with the resultant loss of STSV2 but not SMV1. SMV1 was shown to activate adaptation while itself being resistant to CRISPR-mediated adaptation and DNA interference. Exceptionally, a single clone S-1 isolated from an SMV1 + STSV2-infected culture, that carried STSV2-specific spacers and had lost STSV2 but not SMV1, acquired spacers from SMV1. This effect was also reproducible on reinfecting wild-type host cells with a variant SMV1 isol...
1781933235
Intraglomerular Synthesis of Complement C3 and Its Activation Products in IgA Nephropathy
Nephron, 2001
Complement activation is thought to be pathologically important in IgA nephropathy (IgAN). Although C3 deposition in the mesangium is found in IgAN, the origin of C3 is not clear. We recently demonstrated intraglomerular C3 synthesis in the human kidney; however, the activation and pathological role of locally synthesized C3 remains unclear. Here we performed nonradioactive in situ hybridization for C3 mRNA and immunohistochemistry for C3 and its activation products, such as C3d and membrane attack complex (MAC), to determine whether locally produced C3 in glomeruli was activated in IgA nephropathy.Renal samples from 14 patients with IgAN and 5 with minimal change nephrotic syndrome (MCNS) were examined. Uninvolved portions of surgically removed kidneys with...
1781933235
Using Ultrasound-guided PIV Insertion in the Pediatric Population to Decrease Insertion Attempts
Journal of Radiology Nursing, 2021
Intravenous (IV) therapy using a peripheral IV (PIV) in children is a medical intervention frequently used in hospitals. Current evidence supports ultrasound-guided PIV placement in the adult patient population. The purpose of this study was to implement an evidence-based practice approach to determine if ultrasound-guided IV insertion decreased the number of attempts for successful cannulation and improved staff and patient satisfaction with the treatment in the pediatric inpatient population. Data collection was conducted in a pediatric medical surgical unit and pediatric intensive care unit (PICU). After the implementation of ultrasound-guided IV insertion, the average number of attempts necessary for successful insertion decreased from 2 to 1.37. Finding...
1781933235
Religiosity and Homonegativism: A Path-Analytic Study
Basic and Applied Social Psychology, 1988
Religiosity has been shown to be related to negative attitudes toward homosexuals. We hypothesized that the dimension of ethical conservatism is the major intervening variable that links religiosity to homonegativity. Other variables hypothesized to predict homonegativity included respondents' sex, sexual preference, belief about the amount of choice in sexual orientation, and number of gay friends. A path model of these relationships was proposed and was tested on college students who responded to items measuring the variables in the model. Regression analyses supported the hypothesis that religiosity predicted ethical conservatism, which in turn predicted homonegativity. The model accounted for 50% of the variability in the homonegativity items. These find...
1781933235
Influence of drought stress on pistil physiology and reproductive success of twoGossypium hirsutumcultivars differing in drought tolerance
Physiologia Plantarum, 2019
The causes of reproductive failure under drought stress (DS) are poorly understood. We hypothesized that reproductive failure was related to drought-induced changes in pistil biochemistry. To address this hypothesis, a water deficit-induced experiment was conducted with two cotton cultivars (Dexiamian 1, drought tolerant; Yuzaomian 9110, drought sensitive). Results showed that DS decreased the photosynthesis of subtending leaf and downregulated sucrose transporter gene (GhSUT-1) expression in pistil for both cultivars, resulting in lower pistil carbon accumulation which was reflected in the decreased starch accumulation. Lower starch, as potential energy, and adenosine triphosphate (ATP), as direct energy, in droughted pistils suggested less energy for polle...
1781933235
Apoptin-induced cell death is modulated by Bcl-2 family members and is Apaf-1 dependent
Oncogene, 2005
Apoptin, a chicken anemia virus-derived protein, selectively induces apoptosis in transformed but not in normal cells, thus making it a promising candidate as a novel anticancer therapeutic. The mechanism of apoptin-induced apoptosis is largely unknown. Here, we report that contrary to previous assumptions, Bcl-2 and Bcl-xL inhibit apoptin-induced cell death in several tumor cell lines. In contrast, deficiency of Bax conferred resistance, whereas Bax expression sensitized cells to apoptin-induced death. Cell death induction by apoptin was associated with cytochrome c release from mitochondria as well as with caspase-3 and -7 activation. Benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl ketone, a broad spectrum caspase inhibitor, was highly protective against apopti...
1781933235
Reduction of Energetic Ion Production in Hollow Cathodes by External Gas Injection
Journal of Propulsion and Power, 2013
Studies of the hollow-cathode discharge have shown the existence of energetic ions at high-discharge currents that are likely responsible for the high erosion rates observed on the cathode keeper electrode. This work examines the effect of neutral gas injection in the discharge plume of a 250 A lanthanum hexaboride hollow cathode on the production of energetic ions to determine the conditions that yield cathode operation and life. Two different gas injector types are used to deliver neutral gas into the discharge plume and a retarding-potential analyzer is used for ion energy measurements. The flow splits between the cathode internal and external flows, and the number and locations of the external gas injection sites are examined as a function of the dischar...
1781933235
Channel deformation of bilayer material using tool rollers: part II-effect of layer thickness on springback
Advances in Materials and Processing Technologies, 2021
In this second part of the two-part paper, the layer thickness in the top-layer aluminium alloy and bottom-layer aluminium alloy samples were changed to see the effect if layer thickness has any influence on the deformation and springback behaviour. Four thickness were considered 0.2, 0.4, 0.6, and 0.8 mm for aluminium layer either as a top layer or the bottom layer. To match the bilayer thickness of 1 mm, the remaining thickness was given to the carbon fibre composite layer. Again the 10-process variation were simulated for each layer thickness of aluminium material and results were presented. As found in the first part of the paper the fixed roller and no roller process provides the highest springback in all considered cases. Three distinct regions in the ...
1781933235
Assessment of learned changes in stimulus salience as a consequence of preexposure to a single stimulus: Use of a change blindness task
Learning and Motivation, 2017
Abstract In a preexposure phase, all the participants were instructed to conduct a task involving mental mathematical operations. For Group EXPOSED, the instructions for this task, and the operations to be performed, were introduced by the image of a robot. Group CONTROL was not exposed to the image of the robot during this phase. At the beginning of the subsequent change blindness phase, all the participants were exposed to the image of the robot for 60 s. During this time, they were informed that several changes were to be included in that image, and that their task was to detect the greatest number of possible changes. Immediately after, a sequence of eight 2-s. screens with the image of the robot was initiated, and a blank screen lasting 0.5 s. was int...
1781933235
Depression History, Depressive Symptoms, and Incident Dementia: The 3C Study
JAD, 2011
The aim of our study was to investigate whether depression assessed by different markers predicts the risk of incident dementia in elderly individuals. Data was derived from the 3C cohort study conducted in community-dwelling individuals aged 65 years and over, randomly recruited from electoral rolls of three French areas and followed up for four years (1999-2001 through 2004) with assessments every 2 years. The study sample comprised 7989 dementia-free individuals (mean age, 74.0 years; 61% women) assessed at baseline for current or past Major Depressive Episodes (MDE) based on MDE module of the Mini International Neuropsychiatric Interview, self-reported lifetime treated depression, and level of depressive symptoms using the Center for Epidemiologic Studie...
1781933235
Rhodium carbonyl cluster chemistry under high pressure of carbon monoxide and hydrogen. 2. Synthesis of [Rh14(CO)25]4-
Inorg. Chem., 1981
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRhodium carbonyl cluster chemistry under high pressure of carbon monoxide and hydrogen. 2. Synthesis of [Rh14(CO)25]4-Jose L. Vidal and R. C. SchoeningCite this: Inorg. Chem. 1981, 20, 1, 265–269Publication Date (Print):January 1, 1981Publication History Published online1 May 2002Published inissue 1 January 1981https://doi.org/10.1021/ic50215a052RIGHTS & PERMISSIONSArticle Views56Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing th...
1781933235
Wind power and photovoltaic power: How to improve the accommodation capability of renewable electricity generation in China?
Int J Energy Res, 2018
China's wind curtailment and photovoltaic curtailment was one of the prominent issues in 2014, and the renewable curtailment worsened in 2015. With the rapid growth of renewables, the phenomenon of the insufficiency in renewable accommodation capability is becoming more and more serious in 2016. In that case, the problem of the insufficient accommodation capability is pointed out by analyzing China's development requirements. The renewable power generation scale, the renewable power consumption, and the restrictions on the renewable electricity generation are discussed from the China's market perspective. Meanwhile, the legal environment, the planning requirement, the institutional setting, and the policy tools are introduced from the perspective of governme...
1781933235
Binding of Serotonin and N1-Benzenesulfonyltryptamine-Related Analogs at Human 5-HT6 Serotonin Receptors: Receptor Modeling Studies
J. Med. Chem., 2008
A population of 100 graphics models of the human 5-HT6 serotonin receptor was constructed based on the structure of bovine rhodopsin. The endogenous tryptamine-based agonist serotonin (5-HT; 1) and the benzenesulfonyl-containing tryptamine-derived 5-HT6 receptor antagonist MS-245 (4a) were automatically docked with each of the 100 receptor models using a genetic algorithm approach. Similar studies were conducted with the more selective 5-HT6 receptor agonist EMDT (5) and optical isomers of EMDT-related analog 8, as well as with optical isomers of MS-245 (4a)-related and benzenesulfonyl-containing pyrrolidine 6 and aminotetralin 7. Although associated with the same general aromatic/hydrophobic binding cluster, 5-HT (1) and MS-245 (4a) were found to preferenti...
1781933235
Theoretical Study on the Hydrogen Bonding Interactions in Complexes of 5‐Hydroxytryptamine with Water
Chin. J. Chem., 2013
The energies, geometries and harmonic vibrational frequencies of 1:1 5-hydroxytryptamine-water (5-HT-H2O) complexes are studied at the MP2/6-311++G(d,p) level. Natural bond orbital (NBO), quantum theory of atoms in molecules (QTAIM) analyses and the localized molecular orbital energy decomposition analysis (LMO-EDA) were performed to explore the nature of the hydrogen-bonding interactions in these complexes. Various types of hydrogen bonds (H-bonds) are formed in these 5-HT-H2O complexes. The intermolecular C4H55-HT···Ow H-bond in HTW3 is strengthened due to the cooperativity, whereas no such cooperativity is found in the other 5-HT-H2O complexes. H-bond in which nitrogen atom of amino in 5-HT acted as proton donors was stronger than other H-bonds. Our re...
1781933234
Effect of Sex Hormones on Ethanol Induced Fatty Infiltration of Liver in Rats
Experimental Biology and Medicine, 1958
Female rats showed a more severe fatty infiltration of the liver than did male rats following ethanol intoxication. Administration of estradiol to male rats, or ovariectomy of female rats, prior to such intoxication, did not affect this fatty infiltration. On the other hand, administration of testosterone to female rats reduced the liver lipid concentrations to values similar to those obtained with males, while castration of males increased the liver lipid concentrations to those obtained with females. Castrated male rats, when treated with testosterone however, no longer showed liver lipid values that were higher than those of intact males. These results suggest that testosterone exerts a lipotropic action on ethanol-induced fatty infiltration of the livers...
1781933234
Slow dark optical solitons caused by cross talk among optical transitions
Optics Communications, 2005
We study the formation of slow dark optical solitons in a two-photon resonance Raman scheme. For a four-level atomic medium with two ground and two closely separated excited states, two transitions between one ground state and two excited states are coupled simultaneously by a strong cw laser field. This cross talk among optical transitions can modify the linear and nonlinear responses of another weak pulse probing the transition between the other ground state and one excited state. Under two-photon resonance condition and with appropriate one-photon detuning, we can obtain cancellation of the linear absorption, enhancement of Kerr nonlinearity, and slow group velocity propagation of the weak probe pulse. As a consequence, slow dark optical solitons can be f...
1781933234
Planning an Intergenerational Shared Site: Nursing-Home Staff Perspectives
Journal of Intergenerational Relationships, 2016
Nursing-home staff perspectives on the development of intergenerational shared sites involving nursing homes and child-care centers is lacking. We use a strengths-based and community capacity framework to learn of the perceived benefits and burdens for nursing-home staff within a nursing home planning to implement a shared-site intergenerational program. Forty-two nursing-home staff completed a survey. Almost three-quarters of the participants either indicated strong positive support or saw more pros than cons in opening the child-care center. Over 25% of participants indicated that it was very possible they would use this service if it were available. Quantitative and qualitative results indicated existing strengths and areas to build capacity around four t...
1781933234
Promoting advance directives among elderly primary care patients
J Gen Intern Med, 2004
OBJECTIVE: To determine efficient ways of promoting advance directives among heterogeneous populations of elderly ambulatory patients. DESIGN: One-year quasi-experimental trial. SETTING: Five suburban and urban health centers in one region of a large managed care organization. One additional suburban center served as a control site. PARTICIPANTS: Individuals ages 65 and older (N=2,120) who were continuously enrolled and had a health maintenance visit with their primary care provider during the study year. INTERVENTION: Physician education (oral and written) and physician and patient prompts to discuss advance directives. MAIN RESULTS: Sixty-six (7.8%) of patients at the intervention centers completed new advance directives, versus 9 of 1,277 (
1781933234
Electrospun PVA/HAp nanocomposite nanofibers: biomimetics of mineralized hard tissues at a lower level of complexity
Bioinspir. Biomim., 2008
Based on the biomimetic approaches the present work describes a straightforward technique to mimic not only the architecture (the morphology) but also the chemistry (the composition) of the lowest level of the hierarchical organization of bone. This technique uses an electrospinning (ES) process with polyvinyl alcohol (PVA) and hydroxyapatite (HAp) nanoparticles. To determine morphology, crystalline structures and thermal properties of the resulting electrospun fibers with the pure PVA and PVA/HAp nanocomposite (NC) before electrospinning various techniques were employed, including transmission electron microscopy (TEM), high-resolution TEM (HR-TEM), scanning electron microscopy (SEM), x-ray diffraction (XRD), differential scanning calorimetry (DSC) and ther...
1781933234
A Workshop on Measuring the Progression of Atrophy Secondary to Stargardt Disease in the ProgStar Studies: Findings and Lessons Learned
Trans. Vis. Sci. Tech., 2019
The Progression of Atrophy Secondary to Stargardt Disease (ProgStar) studies were designed to measure the progression of Stargardt disease through the use of fundus autofluorescence imaging, optical coherence tomography, and microperimetry. The overarching objectives of the studies were to document the natural course of Stargardt disease and identify the most appropriate clinical outcome measures for clinical trials assessing the efficacy and safety of upcoming treatments for Stargardt disease. A workshop organized by the Foundation Fighting Blindness Clinical Research Institute was held on June 11, 2018, in Baltimore, MD, USA. Invited speakers discussed spectral-domain optical coherence tomography, fundus autofluorescence, and microperimetry methods and fin...
1781933234
Surface-Charged Zirconia Nanoparticles Prepared by Organophosphorus Surface Functionalization with Ammonium or Sulfonate Groups
Langmuir, 2019
Organophosphorus coupling agents bearing permanently charged functional groups (either cationic quaternary ammonium or anionic sulfonates) were synthesized and used for the modification of zirconia nanoparticles with a diameter
1781933234
Application of least square support vector machines in the prediction of aeration performance of plunging overfall jets from weirs
Expert Systems with Applications, 2009
Aeration is a mass transfer process between the atmosphere and water. Aeration is used for water quality enhancement in sewage treatment plants and in polluted rivers and lakes. This can be enhanced by creating turbulence in the water. Plunging overfall jets from weirs are a particular instance of producing such turbulence. In this paper, two intelligent models are realized to predict the air entrainment rate and aeration efficiency of weirs. Least square support vector machine (LS-SVM) is used as intelligent tool. Threefold cross validation test method is used to evaluate the performance of LS-SVM models. The correlation between predicted and measured values is found 0.99 for air entrainment rate and 0.98 for aeration efficiency. The test results indicate t...
1781933234
Analysis and implementation of a high‐efficiency zero‐voltage‐zero‐current‐switching DC–DC converter
Circuit Theory & Apps, 2011
SUMMARY
A high-efficiency zero-voltage-zero-current-switching DC–DC converter with ripple-free input current is presented. In the presented converter, the ripple-free boost cell provides ripple-free input current and zero-voltage switching of power switches. The resonant flyback cell provides zero-voltage switching of power switches and zero-current switching of the output diode. Also, it has a simple output stage. The proposed converter achieves high efficiency because of the reduction of the switching losses of the power switches and the output diode. Detailed analysis and design of the proposed converter are carried out. A prototype of the proposed converter is developed and its experimental results are presented for validation. Copyright © 2011 John W...
1781933234
Determination of lower bound fracture toughness of a high strength low alloy steel welded joint
Science and Technology of Welding and Joining, 2005
The use of high strength low alloy steels for high performance structures (e.g. pressure vessels and pipelines) requires high strength consumables to produce an overmatched welded joint. This globally overmatched multipass welded joint contains two significantly different microstructures, as-welded and reheated. In this paper, the influence of weld metal microstructure on fracture behaviour is estimated in comparison with the fracture behaviour of composite microstructures (as-welded and reheated). The lower bound of fracture toughness for different microstructures was evaluated by using the modified Weibull distribution. The results, obtained using specimens with crack front through the thickness, indicated low fracture toughness, caused by strength mismatc...
1781933234
Reliability of gynecologic sonographic diagnosis, 1978–1984
American Journal of Obstetrics and Gynecology, 1985
The indications for gynecologic ultrasonography, as well as the reliability of sonographic diagnoses in gynecologic patients, remain controversial. In an effort to evaluate the reliability of the gynecologic sonographic diagnoses rendered at this institution, we analyzed 900 patients available for follow-up. The referral diagnosis was confirmed in 331 patients (36.8%). In 531 patients (59%), sonography established the diagnosis. Thirty-eight (4.2%) of the diagnoses rendered did not reveal the actual status of the patient and were deemed to be “misleading”. Twenty-one of the misleading diagnoses involved the attempted diagnosis of pregnancy at less than 5 weeks' menstrual age. Sonography correctly identified 353 of 370 patients with normal pelvic anatomy....
1781933234
Low Dark-Current, High Current-Gain of PVK/ZnO Nanoparticles Composite-Based UV Photodetector by PN-Heterojunction Control
Sensors, 2016
We propose a solution-processable ultraviolet (UV) photodetector with a pn-heterojunction hybrid photoactive layer (HPL) that is composed of poly-n-vinylcarbazole (PVK) as a p-type polymer and ZnO nanoparticles (NPs) as an n-type metal oxide. To observe the effective photo-inducing ability of the UV photodetector, we analyzed the optical and electrical properties of HPL which is controlled by the doping concentration of n-type ZnO NPs in PVK matrix. Additionally, we confirmed that the optical properties of HPL dominantly depend on the ZnO NPs from the UV-vis absorption and the photoluminescence (PL) spectral measurements. This HPL can induce efficient charge transfer in the localized narrow pn-heterojunction domain and increases the photocurrent gain. It is ...
1781933234
Cigarette smoking, alcohol drinking, and oral and pharyngeal cancer mortality in Japan
Oral Diseases, 2007
To prospectively examine the association of cigarette smoking and alcohol drinking with oral and pharyngeal carcinogenesis, we analyzed data from a nation-wide large-scale cohort study in Japan.A total of 34 136 men and 43 711 women aged 40-79 years were included in the study. The Cox proportional hazard model was used to estimate the relative risk (RR) and 95% confidence interval (95% CI) of oral and pharyngeal cancer for smoking and drinking by sex, while adjusting for age, consumption of green tea, preference for salty foods, and consumption of green yellow vegetables.Current smokers were found to have a higher risk of death caused by oral and pharyngeal cancer compared with non-smokers in both sexes: the RR was 2.6 (95% CI: 1.0-6.7) in men and 8.2 (95% C...
1781933234
Agitation After Subarachnoid Hemorrhage: A Frequent Omen of Hospital Complications Associated with Worse Outcomes
Neurocrit Care, 2016
Agitated delirium is frequent following acute brain injury, but data are limited in patients with subarachnoid hemorrhage (SAH). We examined incidence, risk factors, and consequences of agitation in these patients in a single-center retrospective study. We identified all patients treated with antipsychotics or dexmedetomidine from a prospective observational cohort of patients with spontaneous SAH. Agitation was confirmed by chart review. Outcomes were assessed at 12 months using the modified Rankin Scale (mRS), Telephone Interview for Cognitive Status (TICS), and Lawton IADL (Instrumental Activities of Daily Living) scores. Independent predictors were identified using logistic regression. From 309 SAH patients admitted between January 2011 and December 2015...
1781933234
Three novel species of the anamorphic yeast genus Candida in the Candida intermedia clade found in Japan, Thailand and Taiwan
J. Gen. Appl. Microbiol., 2011
Four strains of yeasts isolated in Japan, Thailand and Taiwan were found to represent three novel species of the genus Candida. The three species are located in a clade including Candida tsuchiyae, Candida thailandica and Candida akabanensis in a tree based on the D1/D2 domain sequences of the large subunit rRNA genes but clearly differentiated from these relative species. Three novel species are proposed for these strains, i. e., Candida berkhoutiae sp. nov., for strains ST-49(T) (=BCC 7749(T)=NBRC 106733(T)=CBS 11722(T)) isolated from insect frass in Thailand and SA13S01 (=NBRC 106053) isolated from soil in Taiwan, Candida ezoensis sp. nov., for strain Y07-1601-2(T) (=NBRC 105019(T)=CBS 11753(T)) isolated from forest soil in Japan, and Candida inulinophila...
1781933234
Successive episodes of synapses production in the developing rat nucleus tractus solitarii
J. Neurobiol., 2002
In the rat nucleus tractus solitarii (NTS), synaptogenesis is thought to occur both pre- and postnatally. The present study was performed to precisely define the timetable of synapse formation in the NTS after birth. Changes in synapse morphology and densities were analyzed between postnatal day 3 (P3) and P28 using electron microscopy and ethanol phosphotungstic acid (E-PTA) staining. The proportion of morphologically immature synapses was high at P3 (38%) and P14 (30%) and low (8–14%) at the other ages investigated (P7, P21, and P28). Synaptic density significantly increased between P7 and P14 (60%) and between P21 and P28 (54%), but did not significantly change between P3 and P7 and between P14 and P21. Mean synaptic diameter also increased over the fir...
1781933234
The pharmacokinetics of [3H]‐vincristine in man
Clin Pharma and Therapeutics, 1977
The pharmacokinetics, metabolism, and excretion of aromatically labeled tritiated vincristine (VCR) was examined in 4 patients. Clearance of radioactivity from the blood was triphasic with half‐life tV2 values of 0.85, 7.4, and 164 min. The initial phases probably represent distribution and binding to formed blood elements which exceeded 50% of the administered dose by 20 min. Excretion of radioactivity was principally fecal, with 33% recovered in the feces by 24 hr and 69% by 72 hr. Considerably less radioactivity (12%) was excreted in the urine over the 72‐hr period. Approximately 40% of fecally excreted and 46% of urinary excreted radiolabel represented metabolites, which suggests that at least 34% of the VCR dose was excreted as metabolites. Plasma m...
1781933234
Dual Layer Security of data using LSB Image Steganography Method and AES Encryption Algorithm
IJSIP, 2015
In today's scenario security of data is very big challenge in any communication.Numerous data security and hiding algorithms have been developed in the last decade.The Digital image Steganography is science of hiding sensitive information in another transmission medium to achieve secure and secret communication.In this paper we present the dual layer of security to the data, in which first layer is to encode data using Least Significant Bit image steganography method and in the second layer encrypt the data using Advance Encryption Standard Algorithm.Steganography does not replace the encryption of data, instead it provides extra security feature to it.In our work secret text message is hiding behind the digital image file and this image file is then encrypt...
1781933234
The theory and framework of integration design of building consumption efficiency based on BIM
Procedia Engineering, 2011
Presently in China many challenges are existing in building energy efficiency, such as the detachment between building design and its energy efficiency, the complicated working process on building efficiency design, the difficulty for architects to get efficient facilities, all of which cause problems to the design of building energy efficiency. This paper bases its design principle on the concept of synergy between building design and energy-saving technology and integrates the energy-saving design experiences of tradition buildings with BIM's powerful ability on information processing and quantitative analysis according to which an energy-saving method and process that builds its foundation on BIM technology and makes the information exchanging among multi...
1781933234
Focus on Epithelialized Palatal Grafts. Part 3: Methods to Enhance Patient Comfort at Palatal Donor Sites
Clin Adv Periodontics, 2019
Postoperative discomfort is a documented complication of the epithelialized palatal graft (EPG) procedure, and the expectation of an unpleasant patient experience may cause some practitioners to avoid EPG altogether. However, EPG affords distinct advantages in a variety of clinical situations, and the postoperative discomfort associated with the procedure can be minimized.Three generally and periodontally healthy patients with gingival recession defects and minimal zones of attached gingiva received mandibular anterior EPG procedures. In all cases, collagen membranes were trimmed to fit the palatal donor sites and sutured in place. Two patients reported minimal donor site discomfort at any time point. One patient with large bilateral donor sites reported mod...
1781933234
Incidence matrices with the consecutive 1’s property
Bull. Amer. Math. Soc., 1964
Abstract : Let A = (aij) be an m-by-n matrix whose entries aij are all either 0 or 1. For certain applications it is of interest to know whether or not there is an m-by-m permutation matrix P such that the 1's in each column of PA occur in consecutive positions. In this note certain results having relevance to this problem are stated. Proofs of these results together with computationally effective algorithms for deciding the question are to be published elsewhere. The problem formulated above is directly related to that of determining whether a given finite, undirected graph is an interval graph. Although necessary and sufficient conditions are known for the solution of this latter problem, the approach used here is quite different from those used heretofore...
1781933234
Undergraduate Music Therapy Education and Training: Current Status and Proposals for the Future
Journal of Music Therapy, 1990
To establish the current status of undergraduate music therapy education and training, 66 microfiche copies of college and university catalogues were examined. Information regarding requirements in music therapy, music, natural and behavioral sciences, and general education was collected. The collected da ta were then compared against the curricular standards set forth by the National Association for Music Therapy. in addition, the authors examined existing cornpilations of music therapy compstenciea, evaluating each for its usefulness in determining curriculum for music therapy education and training. Shortcomings and strengths in the present music therapy curriculum are identified based on competency research findings. The authors suggest methods for resol...
1781933233
Variation for constitutive flavonols and morphological traits in a new white clover population
Environmental and Experimental Botany, 2014
Abstract Breeding forage legumes combining high levels of stress-protective secondary metabolites and high herbage yield are possible. Previous findings suggested a trade-off between flavonol glycosides and biomass production in white clover ( Trifolium repens L.), with population specific evidence indicating that association. The present study used a novel white clover first filial ( F 1 ) reciprocal cross ( n = 130, 3 replications in pots) between the productive cultivar “Kopu II” and the cold- and drought stress-resistant population “Tienshan”. The conditions were non-limiting as the plants were watered at regular intervals as needed, to establish a baseline for both constitutive flavonol glycosides and above-ground biomass production. This stu...
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Foreword
Current Problems in Cardiology, 1994
Timing plays a crucial role in sensorimotor function. However, the neural mechanisms that enable the brain to flexibly measure and reproduce time intervals are not known. We recorded neural activity in parietal cortex of monkeys in a time reproduction task. Monkeys were trained to measure and immediately afterward reproduce different sample intervals. While measuring an interval, neural responses had a nonlinear profile that increased with the duration of the sample interval. Activity was reset during the transition from measurement to production and was followed by a ramping activity whose slope encoded the previously measured sample interval. We found that firing rates at the end of the measurement epoch were correlated with both the slope of the ramp and ...
1781933233
Validated UPLC–MS/MS method for determination of hordenine in rat plasma and its application to pharmacokinetic study
Journal of Pharmaceutical and Biomedical Analysis, 2015
Hordenine is an active compound found in several foods, herbs and beer. In this work, a sensitive and selective UPLC–MS/MS method for determination of hordenine in rat plasma was developed. After addition of caulophylline as internal standard (IS), protein precipitation by acetonitrile–methanol (9:1, v/v) was used as sample preparation. Chromatographic separation was achieved on a UPLC BEH HILIC (2.1 mm × 100 mm, 1.7 μm) with acetonitrile (containing 10 mM ammonium formate) and water (containing 0.1% formic acid and 10 mM ammonium formate) as mobile phase with gradient elution. An electrospray ionization source was applied and operated in positive ion mode; multiple reaction monitoring (MRM) mode was used for quantification using target fragment ions m...
1781933233
Effects of carbohydrate content on the seasonal rooting of vegetative and reproductive cuttings of olive
Journal of Horticultural Science, 1991
SummaryExperiments on the rooting of vegetative and reproductive cuttings of olive showed that the availability and mobilization of carbohydrates towards the base of the cuttings were essential for rooting. Seasonal variation in the rooting of vegetative and reproductive cuttings was associated with concomitant changes in carbohydrate concentrations in the bases of the cuttings. Rooting of cuttings with the reproductive organs attached was prevented by fruit growth or fruit ripening, as carbohydrates were diverted towards the reproductive organs rather than to the IBA-treated bases of the cuttings. However, the failure of rooting in winter for most types of cuttings could not be explained in terms of carbohydrate availability. Similarly, the role of the infl...
1781933233
Calcitonin increases transcription of parathyroid hormone-related protein via cAMP
Molecular and Cellular Endocrinology, 1993
Transcriptional regulation of the human parathyroid hormone-related protein (PTHrP) gene by calcitonin was examined in a lung cancer line (BEN cells). Northern analysis demonstrated that calcitonin caused a rapid 4.5-fold elevation in PTHrP mRNA. Transient transfection of a construct containing 1119 base pairs of the human PTHrP gene 5' to the ATG start site of translation, fused to the CAT reporter sequence, was used to demonstrate a five-fold increase in transcription by calcitonin. Similar increases were also observed when transfected cells were exposed to a number of cAMP agonists including forskolin, as well as isobutyl-methylxanthine. A putative cAMP responsive element (5'-TGACTTCA-3') present within exon 4 was placed upstream of the heterologous SV40 ...
1781933233
Embryonic experience to predation risk affects tadpoles of the common frog (Rana temporaria)
archiv_hydrobiologie, 2006
Amphibians are known to exhibit phenotypic plasticity in response to variations in predation pressure. Data also indicate that developmental changes can be induced by embryonic exposures to predator non-contact cues. However, the possible consequences of such exposures on larval behavioural activity and sensitivity to chemical cues from predators have remained unexplored. These laboratory experiments examine the effects of predation cues experienced during embryonic development on some morphological and behavioural traits in hatchlings and tadpoles of the common frog (Rana temporaria). Eggs were raised until hatching in the nonlethal presence of either a sympatric predator (larval spotted salamander, Salamandra salamandra), or an allopatric predator (juvenil...
1781933233
A real-time data-driven collaborative mechanism in fixed-position assembly systems for smart manufacturing
Robotics and Computer-Integrated Manufacturing, 2020
Assembly stations are important hubs that connect massive material, information, human labor, etc. The fixed-position assembly systems for complex products may deal with hundreds of thousands of processes, making them vulnerable to manufacturing exceptions. Many scheduling problems were described and solved in the past decades, however, the gap between theoretical models and industrial practices still exist. To achieve a practical method for the dynamic scheduling in case of exceptions while reducing the impact brought by the exceptions, an Intelligent Collaborative Mechanism (ICM) was proposed where negotiations on resource configuration may happen among tasks (i.e. assembly processes). The intercommunication among resources was guaranteed by the data-drive...
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Coupled superconducting qudit-resonator system: Energy spectrum, state population, and state transition under microwave drive
Phys. Rev. B, 2018
Superconducting quantum multilevel systems coupled to resonators have recently been considered in some applications such as microwave lasing and high-fidelity quantum logical gates. In this work, using an rf-SQUID type phase qudit coupled to a microwave coplanar waveguide resonator, we study both theoretically and experimentally the energy spectrum of the system when the qudit level spacings are varied around the resonator frequency by changing the magnetic flux applied to the qudit loop. We show that the experimental result can be well described by a theoretical model that extends from the usual two-level Jaynes-Cummings system to the present four-level system. It is also shown that due to the small anharmonicity of the phase device a simplified model captu...
1781933233
Analysis of the structure of layers on U02 leached in H2O
Journal of Nuclear Materials, 1996
Abstract A brief description is given on nuclear techniques (Rutherford backscattering/channeling, resonance scattering and elastic recoil detection analysis using energetic He-ions) used in the analysis of surfaces of UO2 single crystals leached in demineralized water with different pH-values at temperatures up to 200°C. The rate-law for layer-growth and the composition of the layers formed on U02 depended on T and pH-value. For temperatures between 150 and 200°C and pH in the range 6 to 10, a t 1 2 - law was found for growth of U3O7 layers; the deduced activation enthalpy of 0.7 ± 0.1 eV is compatible with rate-controlling diffusion of oxygen-interstitials through the leach layers. These were water-free and retained some coherence with the U02. A thin (...
1781933233
Oriented Growth of Gold Nanowires on MoS2
Adv Funct Materials, 2015
Layered 2D materials serve as a new class of substrates for templated synthesis of various nanomaterials even with highly dissimilar crystal structures; thus overcoming the lattice constraints of conventional epitaxial processes. Here, molybdenum disulfide (MoS2) is used as a prototypical model substrate for oriented growth of in-plane Au nanowires (NWs) despite the nearly 8% lattice mismatch between MoS2 and Au. Au NWs on the MoS2 surface are oriented along three symmetrically equivalent directions within the substrate arising from the strong Au–S binding that templates the oriented growth. The kinetics of the growth process are explored through experiments and modeling. Strong charge transfer is observed between Au NWs and MoS2, resulting in degenerate p...
1781933233
Mutable locks: Combining the best of spin and sleep locks
Concurrency and Computation, 2020
In this article we present Mutable Locks, a synchronization construct with the same execution semantic of traditional locks (such as spin locks or sleep locks), but with a self-tuned optimized trade off between responsiveness---in the access to a just released critical section---and CPU-time usage during threads' wait phases. It tackles the need for modern synchronization supports, in the era of multi-core machines, whose runtime behavior should be optimized along multiple dimensions (performance vs resource consumption) with no intervention by the application programmer. Our proposal is intended for exploitation in generic concurrent applications where scarce or none knowledge is available about the underlying software/hardware stack and the actual workload...
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Isospin breaking in the pion-nucleon coupling from QCD sum rules
Phys. Rev. C, 1997
We use QCD sum rules for the three-point function of a pseudoscalar and two nucleonic currents in order to estimate the charge dependence of the pion-nucleon coupling constant ${g}_{\mathrm{NN}\ensuremath{\pi}}$ coming from isospin violation in the strong interaction. The effect can be attributed primarily to the difference of the quark condensates $〈\ifmmode \bar{u}\else \={u}\fi{}u〉$ and $〈\mathrm{d\ifmmode\bar\else\textasciimacron\fi{}}d〉$. For the splitting ${(g}_{\mathrm{pp}{\ensuremath{\pi}}_{0}}\ensuremath{-}{g}_{\mathrm{nn}{\ensuremath{\pi}}_{0}}{)/g}_{\mathrm{NN}\ensuremath{\pi}}$ we obtain an interval of $1.2\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}2}$ to $3.7\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}2}$, the uncert...
1781933233
Direct control of fixation times in scene viewing: Evidence from analysis of the distribution of first fixation duration
Visual Cognition, 2012
Participants' eye movements were monitored in two scene viewing experiments that manipulated the task-relevance of scene stimuli and their availability for extrafoveal processing. In both experiments, participants viewed arrays containing eight scenes drawn from two categories. The arrays of scenes were either viewed freely (Free Viewing) or in a gaze-contingent viewing mode where extrafoveal preview of the scenes was restricted (No Preview). In Experiment 1a, participants memorized the scenes from one category that was designated as relevant, and in Experiment 1b, participants chose their preferred scene from within the relevant category. We examined first fixations on scenes from the relevant category compared to the irrelevant category (Experiments 1a and...
1781933233
Modelling of colour perception of different age groups using artificial neural networks
Expert Systems with Applications, 2008
Colour is a subjective term which changes according to each person's view. We should define colour physically to work with it in terms of printing or any other professional study. However, enabling the observation of colour in terms of sales and marketing and product design and development is as important as product and its packaging. The perception of colour and tendencies to colours will be different for people of different age groups and socio-economical levels. In this study, different colour samples will be shown to four different groups of primary school, university, midage and elderly people and to two different categories, namely men and women. The aim of the study is to determine which colour is more perceived and adopted by which group and which ca...
1781933233
Three-dimensional nano-heterojunction networks: a highly performing structure for fast visible-blind UV photodetectors
Nanoscale, 2017
Visible-blind ultraviolet photodetectors are a promising emerging technology for the development of wide bandgap optoelectronic devices with greatly reduced power consumption and size requirements. A standing challenge is to improve the slow response time of these nanostructured devices. Here, we present a three-dimensional nanoscale heterojunction architecture for fast-responsive visible-blind UV photodetectors. The device layout consists of p-type NiO clusters densely packed on the surface of an ultraporous network of electron-depleted n-type ZnO nanoparticles. This 3D structure can detect very low UV light densities while operating with a near-zero power consumption of ca. 4 × 10-11 watts and a low bias of 0.2 mV. Most notably, heterojunction formation d...
1781933233
Multiscale investigation of crack path and microstructural changes during liquid metal embrittlement of 304L austenitic steel in liquid sodium
Corrosion Science, 2017
Abstract Fracture micro-mechanisms and crack path of embrittled austenitic steel 304L by liquid sodium strained at 4.2 × 10−7 m s−1 and 573 K are investigated underneath the fracture surface by transmission electron microscopy down to the nanoscale. Automated crystal orientation and phase mapping analyses show that abundant martensitic transformation (γ austenite → α’ martensite) as well as mechanical twinning occur during the deformation of austenite and play a major role in the fracture process. A correlation between the fracture surface features and the underlying microstructural interfaces is evidenced, strengthening the conclusion that liquid metal embrittlement by sodium of austenitic steels is basically an interfacial cracking phenom...
1781933233
Increased Pulmonary Response to Inhaled Endotoxin in Lactating Rats
Am Rev Respir Dis, 1993
An important aspect of risk assessment is identification of subpopulations particularly susceptible to the effects of inhaled pollutants. The present study examined whether female rats were more sensitive during lactation to the acute pulmonary injury produced by inhaled endotoxin. Lactating and age-matched virgin female rats were exposed to aerosols of saline or endotoxin for 3 h and lavaged at 24 h after exposure. No significant differences in lactate dehydrogenase, β-glucuronidase, total protein, and total cell and PMN counts were observed between virgin and lactating rats after exposure to saline. Each marker of pulmonary injury except β-glucuronidase was 1.5- to 3-fold greater in lactating than in virgin female rats exposed to 29.6 µg/m3 endotoxin. P...
1781933233
Development of a Technique for Callus Induction and Plant Regeneration in <em>Oryza sativa</em> L. var. MRQ74 and MR269
AJFST, 2017
The objective of the present study is to develop callus induction and plant regeneration; an experiment was conducted to investigate the effect of growth regulators on callus induction in rice mature embryo culture. In this experiment, callus was initiated from the mature seed scutellumof two Malaysian indica rice, MRQ74 and MR269. Callus was induced using different concentrations of 2, 4-D and BAP on MS medium under dark condition or under 16/8 h photoperiod conditions. For complete plant regeneration, the calli of both varieties were planted for shoot regeneration on MS media supplemented with different concentrations of BAP and NAA, for root regeneration on IBA. The results revealed that the maximum callus inductions in MRQ74 and MR269 were observed in th...
1781933233
Evaluation of kinetic parameter and mechanical Properties of biobased Epoxy Adhesives in Wood-based Composites for Automotive Applications
Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering, 2020
The relevance of sustainable structural materials is increasing in automotive components for sustainable construction. The sustainable material wood in particular can be used due to the very good specific mechanical material properties and has a high potential to be used as a structural material in hybrid constructions for the automotive components as an veneer laminate with modified epoxy adhesives. The material properties depend strongly on the interface between the capillary structure of the wood and the epoxy adhesive and also on the curing properties at the manufacturing process. In this study an epoxy adhesive (DGEBA) was copolymerized with lignosulphonate, a biobased waste product from the pulp and paper industry, as a sustainable coupling agent and t...
1781933233
Red Knot diet reconstruction revisited: context dependence revealed by experiments at Banc d'Arguin, Mauritania
Bird Study, 2013
Capsule Context-specific equations are needed to reconstruct diet composition and intake rate of Red Knots by the use of shell fragments retrieved from droppings. Aims To explore whether the method to reconstruct Red Knot diet described by Dekinga & Piersma [Dekinga, A. & Piersma, T. 1993. Reconstructing diet composition on the basis of faeces in a mollusc-eating wader, the Knot Calidris canutus. Bird Study 40: 144–156] accurately predicts the diet of Red Knots Calidris canutus canutus outside Northwest Europe, at Banc d'Arguin, Mauritania. Methods Feeding experiments with captive Red Knots on the bivalves Dosinia isocardia or Loripes lucinalis were carried out at Banc d'Arguin, the main wintering area of Red Knot subspecies C. c. canutus. Ingested diets w...
1781933233
In situ immunohistochemical analysis of cell adhesion molecules on human corneal endothelial cells.
British Journal of Ophthalmology, 1992
Interaction of leucocytes with human corneal endothelial cells (HCECs) can be observed in several clinicopathological conditions, such as uveitis, keratitis, and corneal graft rejection. Since leucocyte-endothelial cell interactions involve various adhesion receptors we have analysed the expression and distribution pattern of the neural cell adhesion molecule (NCAM), the intercellular adhesion molecule-1 (ICAM-1), the vascular cell adhesion molecule-1 (VCAM-1), the endothelial leucocyte adhesion molecule-1 (ELAM-1), and the cluster of differentiation antigen-44 (CD44) on flat preparations of normal and organ-cultured HCECs. NCAM and ICAM were constitutively expressed on HCECs whereas VCAM-1, ELAM-1, and CD44 were absent from normal HCECs. However flat mounts...
1781933233
Stochastic Multiperiod OPF Model of Power Systems With HVDC-Connected Intermittent Wind Power Generation
IEEE Trans. Power Delivery, 2014
This paper presents a new model for a stochastic multiperiod optimal power-flow (SMP-OPF) problem which includes an offshore wind farm connected to the grid by a line-commutated converter high-voltage dc link. The offshore wind farm is composed of doubly fed induction generators (DFIGs), and the DFIG's capability curve is considered in order to obtain a more realistic dispatch for wind farms. The uncertainties of wind power generation are also taken into account using a scenario-based approach which can be adopted by the system operator to obtain the optimal active and reactive power schedules for thermal and wind power generation units. To illustrate the effectiveness of the proposed approach, it is applied on the IEEE 118-bus test system. The obtained resu...
1781933233
Substitution of sugarbeet pulp for alfalfa hay in diets for growing rabbits
Animal Feed Science and Technology, 1997
Four rabbit diets were formulated to study the effect of a progressive inclusion (0, 100, 200, and 300 g kg − 1) of sugarbeet pulp (SBP) substitute for alfalfa hay (AH). The control diet contained 500g kg−1 of AH and 190 g kg−1 acid detergent fibre (ADF) on a DM basis. In Experiment 1, 32 Californian x New Zealand White rabbits were used to determine dietary nutrient digestibility. The inclusion of SBP quadratically increased (P < 0.01) digestibility coefficients of NDF, ADF and gross energy, showing a maximum for the diet containing 200g kg−1 of SBP. Crude protein digestibility linearly increased with SBP inclusion (P < 0.05). In Experiment 2, 36 rabbits fed the same diets as in Experiment 1 were used to determine several digestive traits and the ef...
1781933233
Connective tissue growth factor mediates transforming growth factor β-induced collagen expression in human endometrial stromal cells
PLoS ONE, 2019
Adenomyosis is a medical condition defined by the abnormal presence of endometrial tissue within the myometrium, in which fibrosis occurs with new collagen deposition and myofibroblast differentiation. In this study, the effect of several mediators and growth factors on collagen expression was investigated on human endometrial stromal cells (fibroblasts) derived from adenomyotic endometrium.RT-PCR, Western blot analysis, pharmacological interventions and siRNA interference were applied to primary cultured human endometrial stromal cells (fibroblasts). Immunohistochemistry was used to analyze protein expression in adenomyotic endometrium tissue specimens.Of the tested mediators, transforming growth factor β1 (TGFβ1) and its isoforms were effective to induce...
1781933233
Geometric Constraints on the Forming Path in Roll Forming Channel Sections
Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture, 1992
In roll forming, flat strip is progressively deformed by sets of rotating rolls; it is a commercially important metal forming process but not one that has been extensively studied on a scientific basis. This paper introduces a new method of indicating forming severity, the bend angle curve, which shows the bend angle distribution and the geometric restrictions imposed by the shape of the rolls, it includes and extends an existing theoretical model of deformation in the unsupported strip based on a modified minimum energy concept. Experiments were carried out in which a channel section was roll-formed and the shape of the strip measured along the whole deformation region. Good correlation was obtained with the predicted bending angle curve and the results dem...
1781933233
Back and to the Future: From Neurotoxin‐Induced to Human Parkinson's Disease Models
CP Neuroscience, 2020
Parkinson's disease (PD) is an age-related neurodegenerative disorder characterized by motor symptoms such as tremor, slowness of movement, rigidity, and postural instability, as well as non-motor features like sleep disturbances, loss of ability to smell, depression, constipation, and pain. Motor symptoms are caused by depletion of dopamine in the striatum due to the progressive loss of dopamine neurons in the substantia nigra pars compacta. Approximately 10% of PD cases are familial arising from genetic mutations in α-synuclein, LRRK2, DJ-1, PINK1, parkin, and several other proteins. The majority of PD cases are, however, idiopathic, i.e., having no clear etiology. PD is characterized by progressive accumulation of insoluble inclusions, known as Lewy bodi...
1781933233
Pharmacokinetics of a single intramuscular injection of ceftiofur crystalline-free acid in American black ducks (Anas rubripes)
ajvr, 2012
Abstract Objective —To determine the pharmacokinetic properties of 1 IM injection of ceftiofur crystalline-free acid (CCFA) in American black ducks ( Anas rubripes ). Animals —20 adult American black ducks (6 in a preliminary experiment and 14 in a primary experiment). Procedures —Dose and route of administration of CCFA for the primary experiment were determined in a preliminary experiment. In the primary experiment, CCFA (10 mg/kg, IM) was administered to ducks. Ducks were allocated into 2 groups, and blood samples were obtained 0.25, 0.5, 1, 2, 4, 8, 12, 48, 96, 144, 192, and 240 hours or 0.25, 0.5, 1, 2, 4, 8, 24, 72, 120, 168, and 216 hours after administration of CCFA. Plasma concentrations of ceftiofur free acid equivalents (CFAEs) were determin...
1781933233
The effect of macromolecular crowding on protein aggregation and amyloid fibril formation
J of Molecular Recognition, 2004
Macromolecular crowding is expected to have several significant effects on protein aggregation; the major effects will be those due to excluded volume and increased viscosity. In this report we summarize data demonstrating that macromolecular crowding may lead to a dramatic acceleration in the rate of protein aggregation and formation of amyloid fibrils, using the protein alpha-synuclein. The aggregation of alpha-synuclein has been implicated as a critical factor in development of Parkinson's disease. Various types of polymers, from neutral polyethylene glycols and polysaccharides (Ficolls, dextrans) to inert proteins, are shown to accelerate alpha-synuclein fibrillation. The stimulation of fibrillation increases with increasing length of polymer, as well as...
1781933232
Fighting Political Terrorism by Refusing Recognition: A Critique of Frey's Proposal
J. Pub. Pol., 1989
ABSTRACT Frey (1987) proposed a new information policy designed to lower the utility of terrorist action. The policy is predicated on the assumption that terrorists aim to draw public attention to their cause. Therefore, the terrorists' rewards can be reduced by refraining from attributing a particular terrorist act to any one group. Faced with diminished rewards, terrorists are likely to give up violent action or to resort to tactics that put them in greater jeopardy. The present article offers a thorough analysis of Frey's proposal. It shows that the proposal derives from a too limited view of the terrorist strategy and from unrealistic assumptions about the extent to which democratic governments can control the sources and the dissemination of information...
1781933232
Estimation of various mechanical characteristics of human bones during dual energy x-ray absorptiometry: methodology and precision
Bone, 1996
The mechanical competence of bone is determined by its macroscopic geometric characteristics [size, shape, apparent density (BMAD), cortical thickness (CWT), cross-sectional area, trabecular architecture], intrinsic material properties (stiffness, strength), and loading conditions (mode, direction, rate) at a given skeletal site. The main objective of this study was to introduce precise methods for further analysis of dual energy X-ray absorptiometric (DXA) data and for estimating macroscopic mechanical characteristics of bone at several skeletal sites representing both the axial and appendicular skeleton. This study showed that using computational BMAD, CWT and dimensional parameters, different site-specific mechanical characteristics (stiffness and strengt...
1781933232
The Effect of Testosterone in Partially Hepatectomized Female Rats
Scandinavian Journal of Gastroenterology, 1967
The influence of Testosterone treatment on liver regeneration after partial hepatectomy was investigated in female rats, treated with testosterone-3- (p-hexyloxiphenyl)-propionate, a long-acting testosterone preparation. The animals were killed 8 days after the operation. No influence of the hormone was observed on liver weight restoration. The treatment lowered the liver nitrogen concentration before as well as after the operation and the RNA concentration before the operation. It did not influence the postoperative decrease in serum albumin and alpha-1-globulin, but caused an increased concentration of alpha-2-globulin before the operation and of beta-2-globulin after the operation. There was thus no evidence of an anabolic effect of the testosterone admin...
1781933232
Residential segregation and the economic status of black workers: New evidence for an old debate
Journal of Urban Economics, 1991
Scholars have long debated whether ghetto residence lowers the earnings of blacks. Most empirical studies on this question have been flawed because they have not considered the simultaneous effects of choices of work and residence locations and the effects of intrametropolitan variation in rents and wages. This paper estimates a revealed preference model of intraurban location with data from the 1980 Public Use Microdata Sample for Cleveland, Detroit, and Philadelphia to test whether black male household heads who are employed full-time year-round are less likely than whites to live and work at their best locations. We measure the wages, rents, and commuting costs associated with each possible job/residence location combination in these cities for each perso...
1781933232
Physical Responses of Bacterial Chemoreceptors
Journal of Molecular Biology, 2007
Chemoreceptors of the bacterium Escherichia coli are thought to form trimers of homodimers that undergo conformational changes upon ligand binding and thereby signal a cytoplasmic kinase. We monitored the physical responses of trimers in living cells lacking other chemotaxis proteins by fluorescently tagging receptors and measuring changes in fluorescence anisotropy. These changes were traced to changes in energy transfer between fluorophores on different dimers of a trimer: attractants move these fluorophores farther apart, and repellents move them closer together. These measurements allowed us to define the responses of bare receptor oligomers to ligand binding and compare them to the corresponding response in kinase activity. Receptor responses could be f...
1781933232
Hiding and Recovering Electrons in a Dimetallic Endohedral Fullerene: Air-Stable Products from Radical Additions
J. Am. Chem. Soc., 2014
Fullerenyl radicals can be generated by addition of a free radical to a fullerene surface, by nucleophilic addition followed by one-electron oxidation, or by thermal dissociation of singly bonded fullerene dimers. However, fullerenyl radicals are usually very reactive and generally cannot be isolated. On the contrary, we have found that the reactions of the dimetallic endofullerenes, La2@Ih-C80 and La2@D5h-C80, with 3-chloro-5,6-diphenyltriazine resulted in mono-addition of the triazinyl radical to the fullerene cages to yield isolable fullerenyl radicals. The unusual stability of these fullerenyl radicals arises from the confinement of the unpaired electron to an internal, metal-metal bonding orbital. Accordingly, the fullerene cage protects the radical cen...
1781933232
Hormonal Responsiveness of Adenylate Cyclase Activity from Separated Bone Cells
Endocrinology, 1974
This study examines the in vitro hormonal responsiveness of adenylate cyclase activity prepared from different types of bone cells. Adult rat skeletal tissue was separated into four cell populations: periosteum, osteoblasts, osteocytes, and mixed marrow cells. Particulate fractions (2200 x g) prepared from each of the bone cell populations were assayed for adenylate cyclase activity following the procedures of Marcus and Aurbach (6). A linear dose response curve was observed when adenylate cyclase activity from osteoblasts and osteocytes was plotted vs die log dose of parathyroid hormone (PTH) (0.5-15 U/70 μl). The maximum increases in activity were 2- to 4-fold. A dose-related response curve was also observed when activity from these same two cell types wa...
1781933232
Chemistry of Fullerene Epoxides: Synthesis, Structure, and Nucleophilic Substitution-Addition Reactivity
Molecules, 2012
Fullerene epoxides, C60On, having epoxide groups directly attached to the fullerene cage, constitute an interesting class of fullerene derivatives. In particular, the chemical transformations of fullerene epoxides are expected to play an important role in the development of functionalized fullerenes. This is because such transformations can readily afford a variety of mono- or polyfunctionalized fullerene derivatives while conserving the epoxy ring arrangement on the fullerene surface, as seen in representative regioisomeric fullerene polyepoxides. The first part of this review addresses the synthesis and structural characterization of fullerene epoxides. The formation of fullerene epoxides through different oxidation reactions is then explored. Adequate cha...
1781933232
Effects of Glycine on Serum Gonadotropins and Estradiol and on Concentrations of Free Amino Acids in the Middle Hypothalamus in Female Rats
Gynecol Obstet Invest, 1981
The effects of glycine on serum gonadotropins and estradiol (E2) and on concentrations of free amino acids in the middle hypothalamus have been studied in diestrus-1 rats. 20 min after intraperitoneal administration, glycine in doses of 50 and 100 mg had no significant effect on serum luteinizing hormone (LH) levels, but 200 mg significantly elevated serum LH levels. Glycine in doses of 50-200 mg had no effect on serum follicle-stimulating hormone levels at 20 min after intraperitoneal injection. 200 mg of glycine significantly elevated serum LH levels at 20 and 50 min and serum E2 levels at 50 and 80 min after intraperitoneal injection. The effects were maximal at 20 min after injection for LH and at 50 min after injection for E2. 20 min after intraperitone...
1781933232
Acute subretinal abscess in Staphylococcus aureus septicaemia with endophthalmitis showcased by multimodal retinal imaging and with 2-year follow-up
BMJ Case Rep, 2018
A middle-aged man presented to emergency services with central vision loss in the setting of flu-like illness with fever. A striking subfoveal abscess was observed in the right fundus. Focal acute chorioretinal inflammation was noted in the asymptomatic fellow eye. Staphylococcus aureus septicaemia was subsequently diagnosed. He presented with undiagnosed HIV infection and latent syphilis. Serial high-definition multimodal retinal imaging showcased resolution of the dome-shaped subretinal abscess following treatment with intravenous flucloxacillin. A chorioretinal scar swiftly replaced the subfoveal abscess. Peripheral right vision and full left vision was retained. Vision loss due to endogenous endophthalmitis in systemic sepsis is an emergency requiring pr...
1781933232
Travel Distance: a Tool for Nature‐Based Tourism Market Segmentation
Journal of Travel & Tourism Marketing, 2008
The purpose of this study was to determine if there are distinct socio‐demographic and behavioral characteristics among nature‐based visitors based on distance traveled. The study used two concepts—“gravity” and “inertia”—to explain the effect of distance on travel behavior. The results based on a sample of 642 visitors to the Gifford Pinchot National Forest, USA showed that more distant visitors participated more in viewing activities; were more likely to be first time and day visitors; did less camping; spent more money on activities, private lodging, and transportation; visited the destination less frequently; spent longer periods away from home; and had less place attachment than those traveling shorter distances. The implications of dist...
1781933232
Hydrodeoxygenation of lignin-derived phenolic compounds over bi-functional Ru/H-Beta under mild conditions
Fuel, 2015
Bifunctional ruthenium catalysts supported on H-Beta zeolite were designed and applied in the hydrodeoxygenation of lignin-derived phenolic compounds for bio-oil upgrading. The oxygen-containing groups in lignin-derived phenolic monomers and dimers could be efficiently removed through aqueous phase hydrodeoxygenation catalyzed by Ru/H-Beta under very mild conditions, i.e. at 413 K and 4 MPa H2. Characterization results revealed that ruthenium species existed in the form of highly dispersed nanoparticles on H-Beta zeolite, while the presence of both Brønsted and Lewis acid sites in zeolite was crucial for the remarkable hydrodeoxygenation activity. The effects of reaction conditions and catalyst constitution on the catalytic performance of Ru/H-Beta in hydro...
1781933232
The Role of Social-Cognitive and Emotional Factors on Exclusive Breastfeeding Duration
J Hum Lact, 2017
Background: Previous research has suggested that exclusive breastfeeding is likely to be predicted by social-cognitive variables and fear. However, there is little research assessing the role of regret and self-conscious emotions (e.g., pride and guilt) in promoting exclusive breastfeeding. Research aim: The primary aim of this research was to determine whether social-cognitive variables, fear, regret, and self-conscious emotions predict exclusive breastfeeding duration. The secondary aim of this research was to assess whether these factors predict infant-feeding choice (i.e., exclusively breastfed, combination fed, or generally formula fed). Methods: In this nonexperimental one-group self-report survey, 375 mothers rated social-cognitive variables toward br...
1781933232
Chronic Obstructive Pulmonary Disease and Intake of Catechins, Flavonols, and Flavones
Am J Respir Crit Care Med, 2001
Flavonoids have been suggested to protect against chronic lung disease. We studied intake of catechins, flavonols, and flavones in relation to pulmonary function and COPD symptoms in 13,651 adults from three Dutch cities examined from 1994 to 1997. Dietary intake was estimated using a food frequency questionnaire, and flavonoid intake was calculated using specific food composition tables. Pulmonary function (FEV1) was determined by spirometry and COPD symptoms by questionnaire. Associations were presented for the fifth versus the first quintile of intake (Q5-Q1), adjusted for age, height (for FEV1 only), sex, smoking, BMI, and energy intake. Smoking was strongly associated with COPD, independent of dietary effects. Average catechin, flavonol, and flavone int...
1781933232
Pion-nucleon scattering and the πNNcoupling constant in the chiral color dielectric model
Phys. Rev. C, 1995
We apply the chiral color dielectric model to low- and medium-energy scattering within the coupled \ensuremath{\pi}N and \ensuremath{\pi}\ensuremath{\Delta} system. Dynamic baryon states in which quarks are confined by the scalar color dielectric field are constructed in Fock space. Spurious motion of the center of mass is eliminated by constructing momentum eigenstates via a Peierls-Yoccoz projection. The relativistic Lippmann-Schwinger equation is solved for the complex energies of the T matrix poles, and the pole positions of the nucleon and delta are used to fix the few parameters of the model. The S- and P-wave phase shifts, the bare N and \ensuremath{\Delta} masses, the renormalized \ensuremath{\pi}NN and \ensuremath{\pi}N\ensuremath{\Delta} coupling c...
1781933232
Systemic Acquired Resistance and Induced Systemic Resistance in Conventional Agriculture
Crop Science, 2004
Plants possess a range of defenses that can be actively expressed in response to pathogens and parasites of various scales, ranging from microscopic viruses to insect herbivores. The timing of these defense responses is critical and can be the difference between being able to cope or succumbing to the challenge of a pathogen or parasite. Systemic acquired resistance (SAR) and induced systemic resistance (ISR) are two forms of induced resistance; in both SAR and ISR, plant defenses are preconditioned by prior infection or treatment that results in resistance (or tolerance) against subsequent challenge by a pathogen or parasite. Great strides have been made over the past 20 yr in understanding the physiological and biochemical basis of SAR and ISR. Much of thi...
1781933232
Ab initio calculations of thermal radiative properties: The semiconductor GaAs
International Journal of Heat and Mass Transfer, 2010
Spectral reflectance of GaAs from infrared (IR) to ultra-violet (UV) bands is predicted using ab initio calculations. We first predict the spectral dielectric function. Two major mechanisms exist for different photon wavelength, namely, photon–electron coupling in the UV to near-IR region and photon–phonon coupling in the far-IR region. For the near-IR to UV band, the electronic band structure of GaAs is calculated, and the imaginary part of the dielectric function is determined from the band structure using the Fermi’s golden rule. The real part of spectral dielectric function is then derived from Kramer–Kronig transformation. For the far-IR region, ab initio calculations are used to determine the phonon modes, and the dielectric function is then pr...
1781933232
ONSET OF SEAWATER 87SR/86SR EXCURSION PRIOR TO CENOMANIAN-TURONIAN OCEANIC ANOXIC EVENT 2? NEW LATE CRETACEOUS STRONTIUM ISOTOPE CURVE FROM THE CENTRAL PACIFIC OCEAN
The Journal of Foraminiferal Research, 2009
A seawater Sr isotopic excursion toward lower values across the Cenomanian/Turonian boundary has been interpreted to indicate an episode of mantle plume volcanism that might have ultimately triggered Oceanic Anoxic Event (OAE) 2. However, the standard Sr isotope curve is not definitive enough to confirm the exact coincidence of the onset of the 87 Sr/ 86 Sr excursion and the genesis of OAE 2, as revealed by the black shale deposition or positive δ 13 C excursion. New high-precision 87 Sr/ 86 Sr data from Upper Cretaceous chalks in a diagenetically well-constrained Pacific deep-sea section (Deep Sea Drilling Project Site 463), in conjunction with δ 13 C stratigraphy and revised planktonic foraminiferal zonation, show that the onset of the 87 Sr/ 86 Sr shift...
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On a thermodynamically-balanced humidification-dehumidification desalination system driven by a vapor-absorption heat pump
Energy Conversion and Management, 2021
A novel hybrid system consists of an efficient humidification-dehumidification (HDH) desalination unit driven by an absorption (AB) heat pump. A thermodynamically-balanced HDH unit with multiple air extractions is used, while single- and double-effect absorption (SEAB and DEAB, respectively) heat pumps are considered. The proposed systems are examined for simultaneous production of desalinated water and cooling effect under a fixed cooling load of 5 kW. As observed, the SEAB-HDH unit can produce up to 152.4 kg/h of desalinated water at a GOR value of around 10, for 0.002–0.0058 $/l. While the DEAB-HDH system delivers water of up to 135.4 kg/h for 0.0026–0.0098 $/l, at a GOR value approaching 15. Besides, COP values of about 0.50 and 0.81 are recorded for...
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Volatile Organic Compounds Profile Obtained from Processing Steps of Pacific Oysters (
Crassostrea gigas
) as Perspective for Food Industry
Journal of Aquatic Food Product Technology, 2020
In the heat treatment of oysters, many aroma compounds are lost in the cooking steam and water. In this study, aroma compound profiles from oyster processing were identified by gas chromatography- mass spectrometry (GC-MS). The compounds were extracted by headspace-solid phase microextraction (HS-SPME), while the best process conditions such as temperature, extraction time, and desorption time were studied. The aroma compounds were obtained from raw oysters, from oysters after thermal treatment, from water released from raw oysters, from cooking steam, and from oyster boiling juice. All compounds were identified and semi-quantified by GC-MS. The major oyster aroma compounds were 1-octen-3-ol, hexanal, and benzaldehyde. Most of the components from oysters wer...
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Microstructure and Charpy impact properties of ferrite–martensite dual phase API X70 linepipe steel
Materials Science and Engineering: A, 2014
The microstructural changes which occur during intercritical annealing treatment at 780 °C of API X70 High Strength Low Alloy (HSLA) Steel have been investigated. Three treatments were developed to produce dual phase microstructure: Intermediate Quenching Treatment/Air (IQT/A), Intermediate Quenching Treatment/Water (IQT/W) and Step Quenching Treatment (SQT). The IQT/Water treatment resulted in the formation of fine and fibrous martensite morphology uniformly distributed in the ferrite matrix. However, the IQT/Air treatment showed a spherical network of martensite along the ferrite/ferrite grain boundaries. The SQT treatment yielded blocky and banded martensite and ferrite morphology. The experimental results show that the API X70 HSLA steel with finely dis...
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N-Cadherin Interacts with Axin and LRP5 To Negatively Regulate Wnt/β-Catenin Signaling, Osteoblast Function, and Bone Formation
Molecular and Cellular Biology, 2009
Wnt signaling plays an important role in the regulation of bone formation and bone mass. The mechanisms that regulate canonical Wnt signaling in osteoblasts are not fully understood. We show here a novel mechanism by which the adhesion molecule N-cadherin interacts with the Wnt coreceptor LRP5 and regulates canonical Wnt/beta-catenin signaling in osteoblasts. We demonstrate that N-cadherin, besides associating with beta-catenin at the membrane, forms a molecular complex with axin and LRP5 involving the LRP5 cytoplasmic tail domain. N-cadherin overexpression in osteoblasts increases N-cadherin-LRP5 interaction, causing increased beta-catenin degradation and altered TCF/LEF transcription in response to Wnt3a. This mechanism results in decreased osteoblast gene...
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Non-similarity combinatorial problems
Biosystems, 1993
Similarity problems intensively investigated in computational molecular biology have the following two stringology models: find the longest string included in any string of a given finite language, and find the shortest string including every string of a given finite language. These two problems are exemplified by the two well-known pairs of problems, the longest common subsequence (or substring) problem and the shortest common supersequence (or superstring) problem, interpretations. In this paper we consider opposite problems connected with string non-inclusion relations: find the shortest string included in no string of a given finite language and find the longest string including no string of a given finite language. The predicate "string alpha is not inc...
1781933232
Qualitative identification of permitted and non-permitted colour additives in food products
Food Additives & Contaminants: Part A, 2012
Colour additives are dyes, pigments or other substances that can impart colour when added or applied to food, drugs, cosmetics, medical devices, or the human body. The substances must be pre-approved by the US Food and Drug Administration (USFDA) and listed in Title 21 of the US Code of Federal Regulations before they may be used in products marketed in the United States. Some also are required to be batch certified by the USFDA prior to their use. Both domestic and imported products sold in interstate commerce fall under USFDA jurisdiction, and the USFDA's district laboratories use a combination of analytical methods for identifying or confirming the presence of potentially violative colour additives. We have developed a qualitative method for identifying 1...
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Investigation of intermittency measurement methods for transitional boundary layer flows
Experimental Thermal and Fluid Science, 1996
Three turbulent intermittency methods, namely the u, TERA (turbulent energy recognition algorithm), and M-TERA (modified turbulent energy recognition algorithm) methods, for identifying the intermittent flow characteristics associated with boundary layer transition from laminar to turbulent were considered and compared. The data used were obtained from hot-wire measurements in transitional boundary layer flows on a concave surface with a 2-m radius of curvature and on a flat plate. Comparisons show that the u and TERA methods are more sensitive to the choice of threshold constants than the M-TERA method. In terms of the intermittency distribution across the boundary layer, the values obtained by the u and TERA methods are unrealistically high in the near-wal...
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The influence of age of acquisition on recall and recognition in Alzheimer’s patients and healthy ageing controls in Turkish
Applied Neuropsychology: Adult, 2020
The current study set out to examine the influence of AoA on word recall and recognition tasks in 30 Alzheimer's patients and 28 healthy ageing control group. Each participant was presented with 20 words that critically varied on AoA. A subtest of WAIS-R was employed to establish the vocabulary capacity of participants together with the Mini-Mental State Examination. The pattern of results showed that healthy ageing adults outperformed Alzheimer's patients in recall and recognition tasks and that overall early acquired words had an advantage over late acquired words. The results have implications for developing assessment tools and are discussed within the current theories of age of acquisition and the impact of the neurodegenerative loss of memory in Alzhei...
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Is the global prevalence rate of adult mental illness increasing? Systematic review and meta‐analysis
Acta Psychiatr Scand, 2019
Objectives The question whether mental illness prevalence rates are increasing is a controversially debated topic. Epidemiological articles and review publications that look into this research issue are often compromised by methodological problems. The present study aimed at using a meta-analysis technique that is usually applied for the analysis of intervention studies to achieve more transparency and statistical precision. Methods We searched PubMed, PsycINFO, CINAHL, Google Scholar and reference lists for repeated cross-sectional population studies on prevalence rates of adult mental illness based on ICD- or DSM-based diagnoses, symptom scales and distress scales that used the same methodological approach at least twice in the same geographical region. Th...