1785107532
Effect of band structure on Stark shifts in GaAs quantum wells
Phys. Rev. B, 1989
We have carried out a pseudopotential calculation of Stark effect on electron states in GaAs-${\mathrm{Ga}}_{1\mathrm{\ensuremath{-}}\mathrm{x}}$${\mathrm{Al}}_{\mathrm{x}}$As quantum-well structures. We find that in isolated wells the band-structure effect due to field-induced mixing of bulk \ensuremath{\Gamma} and X states is negligible in electric fields (0--5)\ifmmode\times\else\texttimes\fi{}${10}^{5}$ V/cm. However, in double-barrier structures normally used to study resonant tunneling the effect of \ensuremath{\Gamma}-X mixing drastically reduces the magnitude of critical field, at which quadratic Stark effect and the particle-in-a-box model collapse, to around 2\ifmmode\times\else\texttimes\fi{}${10}^{5}$ V/cm. We predict that this critical field is ...
1785107532
Charged and uncharged D-branes in various string theories
Nuclear Physics B, 2002
We describe how the D-brane spectra of the various ten-dimensional string theories can be related to general properties of the open-closed duality, encoded in the $S$ and $P$ matrices of the conformal field theory. We also complete the classification and the description of non-BPS branes in these string theories, elucidating their non-Abelian structures and the nature of the corresponding super-Higgs mechanisms. We find that the type 0 theories and their orientifolds have two types of uncharged branes, distinguished by their couplings to the closed string tachyon. We also find that the 0A orientifold has the unusual feature of having charged and uncharged branes with identical world-volume dimensions. We conclude with some comments on fractional branes, eluc...
1785107532
Macroevolutionary and morphofunctional patterns in theropod skulls: a morphometric approach
APP, 2012
The synonymization of the cimolestan taxa Cymaprimadon and Chadronia from the Late Eocene Chadron Formation is consistently upheld, despite a lack of supporting evidence. Here we show that the synonymization is unjustified, owing to distinct differences between these taxa in the mandibular tooth count (1-1-3-3 vs. ?-1-4-3), the identity of the enlarged anterior mandibular tooth (incisor versus canine), and the morphology of the crown of m3 (e.g., paraconid on m3 in Cymaprimadon). We also refer a specimen recently collected from the Early Oligocene Brule Formation within the Badlands National Park (BADL 16917) to Chadronia sp., thus making it the youngest occurrence of a pantolestan from North America. Examination of an additional specimen (FMNH UC 349) revea...
1785107532
Optimized IoT service placement in the fog
SOCA, 2017
The Internet of Things (IoT) leads to an ever-growing presence of ubiquitous networked computing devices in public, business, and private spaces. These devices do not simply act as sensors, but feature computational, storage, and networking resources. Being located at the edge of the network, these resources can be exploited to execute IoT applications in a distributed manner. This concept is known as fog computing. While the theoretical foundations of fog computing are already established, there is a lack of resource provisioning approaches to enable the exploitation of fog-based computational resources. To resolve this shortcoming, we present a conceptual fog computing framework. Then, we model the service placement problem for IoT applications over fog re...
1785107532
Dynamics of a single electron in the disordered Holstein model
Phys. Rev. B, 2001
We study, at zero temperature, the dynamics of a single electron in a Holstein model augmented by site-diagonal, binary-alloy type disorder. The average over the phonon vacuum and the alloy configurations is performed within a generalized dynamical coherent potential approximation. We present numerical results for a Bethe lattice with infinite coordination number. In particular, we investigate, in the intermediate electron-phonon coupling regime, the spectral and diffusion properties in the vicinity of the high-energy edge of the lowest polaronic subband. To characterize the diffusion properties, we define a spectrally resolved delocalization time, which is, for a given energy, the characteristic time scale on which the electron leaves a given site. We find ...
1785107532
Synthesis and Characterization of Large‐Area Nanometer‐Thin β‐Ga2O3 Films from Oxide Printing of Liquid Metal Gallium
Physica Status Solidi (a), 2020
Herein, wafer-scale Ga2O3 films are shown, which are synthesized by oxide printing of liquid metal Ga on SiO2/Si and sapphire substrates. This process enables highly uniform ≈2 nm-thick films over ≫1 mm2 areas. The physical properties of these films (as-deposited and after annealing in ambient conditions) are investigated. X-ray photoelectron spectroscopy indicates that the as-prepared films contain significant fractions (up to 8% wt) of Ga metal residue, which completely converts to Ga2O3 after annealing. Results from Raman spectroscopy confirm the presence of β-phase in annealed samples. Transmission electron microscopy images indicate that the films are composed of polycrystalline domains. Photoluminescence is observed in all samples, depicting the t...
1785107532
Establishing the limits of normal cerebral ageing and senile dementias
Br J Psychiatry, 1998
Cognitive deterioration is so commonly observed in the elderly that it is considered by many to be an inevitable feature of the ageing process. Some researchers have proposed that the senile dementias are the inevitable end-point of this process, should the person live long enough. The differentiation of normal cerebral ageing from disease process is important in the selection of control groups for research, and also for clinical decision-making. In the latter context it is important to ask at what level of dysfunction intervention should occur, and whether this should be active or palliative. Cognitive change in the elderly is here considered from biological, neuropsychological and epidemiological viewpoints. Current research suggests that senile dementia i...
1785107532
Disruption of the polyubiquitin gene Ubb causes retinal degeneration in mice
Biochemical and Biophysical Research Communications, 2019
We have previously demonstrated that a reduction in ubiquitin (Ub) levels via disruption of the polyubiquitin gene Ubb results in reactive gliosis and hypothalamic neurodegeneration in mice. However, it is not known whether other neural tissues, apart from the brain, can also be affected by Ubb disruption. We examined the retina, which, being derived from the diencephalon, has the same developmental origin as the hypothalamus. We found that expression levels of Ubb were much higher than those of the other polyubiquitin gene Ubc in the retina. In retinal tissues from Ubb knockout (KO) mice, we found that Ubc expression was upregulated to compensate for the loss of Ubb; however, the Ub pool remained disrupted, with reduced levels of free Ub. To directly demons...
1785107532
Papillary carcinoma of the thyroid. A clinicopathologic study of 241 cases treated at the University of Florence, Italy
Cancer, 1985
A clinicopathologic study of 241 cases of papillary thyroid carcinoma treated at the University of Florence Medical School, Florence, Italy is presented. The features of greatest prognostic value were patient's age at presentation, small tumor size, total encapsulation, extrathyroid extension, multicentricity, and presence of distant metastases. The prognosis of the disease was not influenced by the pattern of tumor growth, presence of solid areas, initial presence or subsequent development of cervical lymph node metastases, type of initial thyroid operation, performance of neck dissection, or prophylactic administration of radioactive iodine. It is concluded that conservative thyroid surgery in the form of lobectomy, without neck dissection or prophylactic ...
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The Effects of Local Economic Development Efforts
American Politics Quarterly, 1998
This research examines the effects of local expenditures on income growth in North Carolina counties. Pooled data from all 100 counties in the state for the years 1981-1990 are analyzed, and empirical tests are conducted to ascertain the relationship between the expenditures and the effect on the dependent variable under a number of time lags The most important finding is that county paved-highway mileage per capita has a significant positive effect on income growth under a number of model specifications. In addition, there is a consistently positive relationship between county per student spending for primary and secondary education and income growth that obtains statistical significance under some model specifications. The findings also indicate that chang...
1785107532
Human health impact from antimicrobial use in food animals
Médecine et Maladies Infectieuses, 2004
There is accumulating evidence that the use of antimicrobials in food-producing animals has adverse human health consequences. The use of antibiotics in food animals selects for resistant pathogens and resistance genes that may be transferred to humans through the consumption or handling of foods of animal origin. Recent studies have demonstrated that antimicrobial-resistance among foodborne bacteria may cause excess cases of illness, prolonged duration of illness, and increased rates of bacteremia, hospitalization, and death. The continued availability of safe and effective antimicrobials for humans and animals depends upon the responsible use of these products. Il y a de plus en plus de preuves que l’utilisation d’antibiotiques dans l’alimentation an...
1785107532
Metal binding by humic acids in recent sediments from the SW Iberian coastal area
Estuarine, Coastal and Shelf Science, 2011
The concentrations of Cu, Zn, Cr, Ni, Pb, As, Mn and Co were determined by Inductively Coupled Plasma–Mass Spectrometry both in recent sediments from different locations of the Huelva littoral (SW Iberian Peninsula) and in their humic acid (HA) fractions in order to evaluate distribution and binding capacity of those trace elements to HAs. In addition, elemental composition (C, N, S) and δ13C values were determined to appraise the sources of organic matter in the area. This study involved the comparison of selected samples taken from different environments including the estuary of the Guadiana River, the main fluvial system of the region, the Tinto and Odiel estuary system and the proximal shelf. Significant positive correlations were found among Cu, Zn, ...
1785107532
Enzymatic hydrolysis of ovalbumin and the functional properties of the hydrolysates
Poultry Science, 2014
Ovalbumin is the predominant protein in egg white and is widely used in cell culture. However, it also can be used to produce peptides with various functional properties. The objectives of this study were to hydrolyze ovalbumin using various enzyme, incubation time, and temperature combinations, and to compare the functional properties of the hydrolysates. Ovalbumin (20 mg/mL) was hydrolyzed with 1% of pepsin, trypsin, α-chymotrypsin, papain, and alcalase, singly or in combination at 37°C, and then the enzymes were inactivated at 100°C for 15 min. Hydrolyzing ovalbumin with pepsin (OAPe), pepsin + papain (OAPePa), pepsin + alcalase (OAPeAl), alcalase + trypsin (OAAlTr), and α-chymotrypsin (OACh) was also effective in producing peptides from ovalbumin, an...
1785107532
Assessing the vaccine effectiveness for hand, foot, and mouth disease in Guangzhou, China: a time-series analysis
Human Vaccines & Immunotherapeutics, 2020
Objective: Hand, foot, and mouth disease (HFMD) is an important public health issue in China. Although efficacy has been demonstrated by randomized controlled trials, the evidence for effectiveness of the monovalent Enterovirus 71 (EV71) vaccine against HFMD remains unknown. This study aimed to assess the vaccine effectiveness for HFMD in Guangzhou, China. Methods: Routinely collected vaccination and HFMD surveillance data were captured from the China Information System for Disease Control and Prevention. We estimated the EV71 vaccine effectiveness using spatial ecologic and time-series analysis approaches. Results: A total of 174,002 HFMD cases under 5 years of age were reported to the Guangzhou, China surveillance system from January 2016 to December 2018....
1785107532
What Encourages Nonprofits' Adoption of Good Governance Policies?
Nonprofit Mgmnt & Ldrshp, 2016
Abstract This study examines how nonprofits' external environments and organizational characteristics explain their likelihood of having written policies for good governance. Findings from the 2010 data of the National Center for Charitable Statistics show that state requirements for registration and annual reporting are not related to a nonprofit's likelihood of adopting such written policies. The results instead indicate that organizations that engage in lobbying activities and operate in metropolitan areas are more likely to have good governance standards. Most of all, the analysis shows that organizational resources, both financial and human, explain differences in the adoption of these policies. These findings suggest that the nonprofit community should...
1785107531
Bacterioruberin and salinixanthin carotenoids of extremely halophilic Archaea and Bacteria: A Raman spectroscopic study
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2013
Laboratory cultures of a number of red extremely halophilic Archaea (Halobacterium salinarum strains NRC-1 and R1, Halorubrum sodomense, Haloarcula valismortis) and of Salinibacter ruber, a red extremely halophilic member of the Bacteria, have been investigated by Raman spectroscopy using 514.5nm excitation to characterize their carotenoids. The 50-carbon carotenoid α-bacterioruberin was detected as the major carotenoid in all archaeal strains. Raman spectroscopy also detected bacterioruberin as the main pigment in a red pellet of cells collected from a saltern crystallizer pond. Salinibacter contains the C40-carotenoid acyl glycoside salinixanthin (all-E, 2'S)-2'-hydroxy-1'-[6-O-(methyltetradecanoyl)-β-d-glycopyranosyloxy]-3',4'-didehydro-1',2'-dihydro-β...
1785107531
Performance of Osteoinductive Biphasic Calcium-Phosphate Ceramic in a Critical-sized Defect in Goats
KEM, 2006
Osteoinductive biomaterials are able of inducing bone formation at ectopic, i.e. extraskeletal implantation sites. It is, however, important to investigate whether osteoinductive biomaterials perform better when implanted orthotopically as well, in particular in clinically relevant criticalsized defects. In this study, an osteoinductive and a non-osteoinductive biphasic calcium-phosphate (BCP) ceramic were compared in a critical-sized iliac wing defect that allows for paired comparison. After 12 weeks of implantation in the critical-sized defect, the osteoinductive BCP1150 ceramic showed significantly more bone than the non-osteoinductive BCP1300 ceramic. In addition, the analysis of fluorochrome markers, which were administered to the animals 4, 6 and 8 wee...
1785107530
Strategic defense and attack for series and parallel reliability systems
European Journal of Operational Research, 2008
A system of independent components is defended by a strategic defender and attacked by a strategic attacker. The reliability of each component depends on how strongly it is defended and attacked, and on the intensity of the contest. In a series system, the attacker benefits from a substitution effect since attacker benefits flow from attacking any of the components, while the defender needs to defend all components. Even for a series system, when the attacker is sufficiently disadvantaged with high attack inefficiencies, and the intensity of the contest is sufficiently high, the defender earns maximum utility and the attacker earns zero utility. The results for the defender (attacker) in a parallel system are equivalent to the results for the attacker (defen...
1785107530
In vivo fitness correlates with host-specific virulence of Infectious hematopoietic necrosis virus (IHNV) in sockeye salmon and rainbow trout
Virology, 2011
The relationship between virulence and overall within-host fitness of the fish rhabdovirus Infectious hematopoietic necrosis virus (IHNV) was empirically investigated in vivo for two virus isolates belonging to different IHNV genogroups that exhibit opposing host-specific virulence. U group isolates are more virulent in sockeye salmon and M group isolates are more virulent in rainbow trout. In both single and mixed infections in the two fish hosts, the more virulent IHNV type exhibited higher prevalence and higher viral load than the less virulent type. Thus, a positive correlation was observed between higher in vivo fitness and higher host-specific virulence in sockeye salmon and rainbow trout. Comparisons of mean viral loads in single and mixed infections ...
1785107530
Orthodontic and surgical management of a patient with severe mandibular deficiency and asymmetry with condylar hypoplasia using 3-dimensional surgical planning in combination with a modified surgery-first approach
American Journal of Orthodontics and Dentofacial Orthopedics, 2020
Progressive improvements in digital technology and surgical techniques have synergized the speed, predictability, and favorable outcomes for patients undergoing surgical-orthodontic treatment with handicapping dentofacial deformities. This case report will demonstrate the management of a patient with severe mandibular hypoplasia, condylar hypoplasia, and mandibular asymmetry. The dentofacial deformity, and consequently, the unaesthetic facial appearance, led to psychosocial stress, symptoms of excessive daytime sleepiness, and functional limitations, especially related to mandibular movements. A modified surgery-first approach was used, which was successfully performed using computer-assisted surgical planning. Postsurgical orthodontics was accomplished with...
1785107530
Factors Associated with Parents’ Knowledge of Gay, Lesbian, and Bisexual Youths’ Sexual Orientation
Journal of GLBT Family Studies, 2010
This study examined factors associated with gay, lesbian, and bisexual (GLB) youths’ parents’ knowledge of their children's sexual orientation. Over a 2-year period, we studied 196 youths whose parents were aware or unaware of their children's sexual orientation, and youths whose sexual orientation became known to their parents. Differences between youths in their sexual orientation development, psychosocial adjustment, support, victimization by parents, and involvement in GLB social activities were considered. Youths whose parents were aware of their sexual orientation indicated that they were more same-sex oriented and reported less internalized homophobia than youths in the other two groups. Youths whose sexual orientation became known had poorer pare...
1785107530
Management of HCV patients with cirrhosis with direct acting antivirals
Liver International, 2013
In recent years, several studies have clearly shown that sustained virological response (SVR) achieved by interferon-based therapies may delay or reduce the risk of hepatocellular carcinoma, liver decompensation and all-causes of mortality in all categories of patients with HCV-related cirrhosis, a condition characterized by a wide heterogeneity of clinical features, especially in patients with compensated disease. Unfortunately, the advanced fibrosis stage has been shown to be associated with poor SVR rates and poor tolerance with Peg-interferon and ribavirin. Therefore, on the basis of its risk/efficacy evaluation, most patients are considered to be ineligible for antiviral therapy with these molecules. Recently, improvement in the knowledge of the HCV lif...
1785107530
Religious Suicide in Islamic Asia
Journal of Conflict Resolution, 1988
Most modern studies of terrorism have been synchronic or ahistorical, focusing on immediate problems and ignoring the more profound conflicts that give rise to terrorist attacks. This failure to take into account long-term conflicts that give rise to terrorist attacks is especially noticeable in the research on Middle Eastern terrorism, for most published studies ignore the shared historical experience of Muslims, especially their cultural memory of their centuries-long confrontation with the West. This article demonstrates that even the most intimidating form of modern terrorism, the suicidal attack, such as that which destroyed the U.S. Marine barracks in Beirut, has been used repeatedly over several centuries by Muslims in three Asian Muslim communities a...
1785107530
Cardinal invariants of dually CCC spaces
Topology and its Applications, 2021
We say that a space X is dually CCC (respectively, weakly Lindelöf, separable) if for any neighbourhood assignment ϕ on X, there is a CCC (respectively, weakly Lindelöf, separable) subspace Y⊂X such that ϕ(Y)={ϕ(y):y∈Y} covers X. In this paper, we mainly show that (1) A dually CCC first countable Hausdorff space has cardinality at most 2c and a dually weakly Lindelöf first countable normal space has cardinality at most 2c. (2) Let Y=∏{Yi:i≤n}, where Yi is a scattered monotonically normal space for any i=0,1,...,n. If a subspace X⊂Y is dually CCC then e(X)≤ω and a normal subspace X⊂Y is DCCC if and only if e(X)≤ω. (3) Assume 2
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A Facile Synthesis of New Polyazaheterocycles via One-Pot Three-Components Condensation Reaction and Study of Their Reactions with Nitrilimines
COS, 2015
A direct and efficient approach for the synthesis of new series of pyrido[3,4-c][1,5]benzothiazepine, pyrido[4,3-d]triazolo[1',5'-a]pyrimidines, pyrido[4,3-d]tetrazolo [1',5'-a]pyrimidine and pyrido[4,3-4',5']pyrimido[1',2'- a]benzimidazoles has been developed via condensation of o-aminothiophenol and heterocyclic amines each with 1-ethyl- 4-piperidinone and the appropriate aldehyde. The reactions were performed in refluxing acetonitrile in the presence of molecular iodine as a catalyst. Also, the 1,3-dipolar cycloadditions of nitrilimines to the latter products were examined and were found to be site- and regioselective. The structures of the new synthesized compounds were established on the basis of spectral data (Mass, IR, 1H and 13C NMR) and elemental an...
1785107530
The Phospha‐Michael Addition in Organic Synthesis
Eur J Org Chem, 2005
Abstract Phosphorus is essential for many reagents in organic synthesis, for ligands of late‐transition metals and for phosphono‐ and phosphanylamino acids, the latter being important isosteres of amino acids. Similar to the Michaelis–Arbuzov and the Michaelis–Becker reaction the phospha‐Michael addition, i. e. the addition of a phosphorus nucleophile to an acceptor‐substituted alkene or alkyne, certainly represents one of the most versatile and powerful tools for the formation of P–C bonds since many different electrophiles and P nucleophiles can be combined with each other. This offers the possibility to access many diversely functionalised products. With this article, we try to give an instructive overview of this reaction. The outline of th...
1785107529
Potent Protective Immune Responses to Senecavirus Induced by Virus-Like Particle Vaccine in Pigs
Vaccines, 2020
Senecavirus A (SVA) is the pathogen that has recently caused porcine idiopathic vesicular disease (PIVD). The clinical symptoms of PIVD are similar to those of acute foot-and-mouth disease and also can result in the death of newborn piglets, thus entailing economic losses. Vaccine immunization is the most effective way to prevent and control SVA. Among all SVA vaccines reported, only the SVA inactivated vaccine has been successfully developed. However, to ensure the elimination of this pathogen, safer and more effective vaccines are urgently required. A virus-like particles (VLPs)-based vaccine is probably the best alternative to inactivated vaccine. To develop an SVA VLPs vaccine and evaluate its immune effect, a prokaryotic expression system was used to pr...
1785107529
Long-term results and prognostic factors in patients with differentiated thyroid carcinoma
Cancer, 1985
A multivariate analysis of the prognostic factors was carried out on a series of 546 differentiated thyroid cancers followed for 8 to 40 years. For survival, the highest risk factor was associated with age; tumors diagnosed in patients younger than 45 years had higher relapse-free survival (RFS) and total survival (TS) rates and a slower growth rate. In children, although the RFS and TS at 15 years were high, they decreased later. The second independent prognostic factor was histology. There was no difference between papillary and follicular well-differentiated (FWD) tumors, but follicular moderately differentiated (FMD) had lower TS and RFS. Among FMD cancers, relapses occurred earlier and the interval between relapse and death was shorter. The third factor...
1785107529
Direct and indirect mechanisms in site occupation of CO molecules on Ni(100) and Pt(111)
Surface Science, 1996
Adsorption of CO onto a cold surface at 20 K has been studied by infrared reflection absorption spectroscopy (IRAS). The occupation ratio of bridged CO to terminal CO species on Ni(100) at 20 K ranges from ∼3.1 to 0.8 at the total coverage from 0.003 to 0.15 ML. Two adsorption processes of direct adsorption of CO molecules on the bare metal surface and indirect collisional site conversion are discussed. At zero-coverage limit, CO tends to accommodate on the site with the larger adsorption energy. Strong coverage dependence of the occupation ratio even at small coverages suggests that the interaction between CO molecules operates at relatively long range (> 10 Å). The isotope experiments suggest that there is substantial interaction between preadsorbed (a...
1785107529
Where Disability and Displacement Intersect: Asylum Seekers and Refugees with Disabilities
International Journal of Refugee Law, 2012
This article addresses a relatively new area of interest for refugee scholars: the effect on refugee law and policy of the UN Convention on the Rights of Persons with Disabilities. The article explains the paradigm shifts that this Convention represents for persons with disabilities who find themselves displaced by war or persecution. It focuses on the two broad areas of most concern to refugee advocates and adjudicators working with persons with disabilities seeking protection as refugees: status determination processes and the interpretation of the definition of refugee. It considers the threshold legal question of whether the obligations enshrined in the Disabilities Convention are owed in respect of refugees – and thus whether they are relevant to refu...
1785107529
Understanding the photoemission distribution of strongly interacting two-dimensional overlayers
Phys. Rev. B, 2017
Photoemission tomography (PT), the analysis of the photoemission intensity distribution within the plane wave final-state approximation, is being established as a useful tool for extracting the electronic and geometric structure of weakly interacting organic overlayers. Here we present a simple method for extending PT, which until now has been based on the calculations of isolated molecules. By including the substrate and a damped plane-wave final state, we are able to simulate the photoemission intensity distribution of two-dimensional molecular overlayers with both strong intermolecular and molecule-substrate interactions, here demonstrated for the model system 3,4,9,10-perylene-tetracarboxylic dianhydride (PTCDA) on Cu(100). It is shown that the interacti...
1785107529
The Plant Microbiome: From Ecology to Reductionism and Beyond
Annu. Rev. Microbiol., 2020
Methodological advances over the past two decades have propelled plant microbiome research, allowing the field to comprehensively test ideas proposed over a century ago and generate many new hypotheses. Studying the distribution of microbial taxa and genes across plant habitats has revealed the importance of various ecological and evolutionary forces shaping plant microbiota. In particular, selection imposed by plant habitats strongly shapes the diversity and composition of microbiota and leads to microbial adaptation associated with navigating the plant immune system and utilizing plant-derived resources. Reductionist approaches have demonstrated that the interaction between plant immunity and the plant microbiome is, in fact, bidirectional and that plants,...
1785107529
Complete sequence of the S RNA of lymphocytic choriomeningitis virus (WE strain) compared to that of pichinde arenavirus
Virus Research, 1985
Previous studies have reported that the 3' half of the small, S, RNA species of the WE strain of lymphocytic choriomeningitis (LCM) virus codes for the viral nucleoprotein in a subgenomic, viral-complementary, mRNA species (Romanowski, V. and Bishop, D.H.L. (1985) Virus Res. 2, 35-51). The complete sequence of the LCM-WE S RNA has now been obtained, indicating that the 5' half of the RNA codes for the viral glycoprotein precursor in a viral-sense sequence that does not overlap the N gene. It is concluded that, like Pichinde virus (Auperin, D. et al. (1984) J. Virol. 52, 897-904), LCM has an ambisense S RNA coding strategy. The LCM-WE S RNA is 3375 nucleotides in length, has a size of 1.14 X 10(6) Da and base composition of 26.1% A, 23.2% C, 21.5% G, 29.2% U....
1785107529
Prediction of Soft Tissue Profile Changes after Sagittal Splitting Ramus Osteotomy and Genioplasty
IJOMS, 2019
The purpose of this study is to improve the accuracy of predicting the soft tissue configuration from the change amounts of the hard tissue landmarks in the patients who underwent combined sagittal splitting ramus osteotomy (SSRO) and genioplasty for skeletal mandibular protraction. The samples for this study consisted of the lateral cephalograms records of 20 surgical orthodontics treated patients. The records of each subject were chosen on the basis of their having pre-treatment and post-treatment lateral cephalograms. Landmarks were traced from each film, and scaled to permit radiographic enlargement. The cartesian coordinates of these points were obtained with the use of calipers, where the coordinate set was first translated to bring the midpoint at sel...
1785107529
Traffic Models for Self-driving Connected Cars
Transportation Research Procedia, 2016
Self-driving and connected vehicles, communicating with one another (V2 V technology) and with the road infrastructure (V2I technology), are a subject of extensive research nowadays and are expected to revolutionize the automotive industry in the near future. The major goal of our work is to design a microscopic traffic simulation model for such vehicles, including a robust protocol for exchanging information. The question arises as to whether such communication system may efficiently improve travel quality while reducing the risk of collisions. For the purpose of our research we created and developed a simulation software. Our tool visualizes traffic flow for custom but simplified road maps. The transport infrastructure includes multiple junctions, optional...
1785107529
Feels and Flows: On the Realness of Menstrual Pain and Cripping Menstrual Chronicity
Feminist Formations, 2018
Exploring discourses of menstrual negativity and menstrual contagion, we argue for a feminist queer crip approach to menstrual pain. Understood as imagined and exaggerated, menstrual pain has been rendered illegible by redemptive models of pain and straight, ableist structures of temporality. We respond to this context of pain-denial by drawing on crip and queer theories on pain and temporality and feminist work on menstruation to argue that menstrual pain is chronic and cyclical pain. Through our own autobiographies of the material and structural conditions of menstrual pain, we offer a contribution to thinking about menstrual pain and its accompanying contagions and chronicities. We do so by exploring discourses of menstrual containment, negativity, and pa...
1785107528
Use of flower model trap to reduce the infestation of greenhouse whitefly on tomato
Journal of Asia-Pacific Entomology, 2008
Flower model trap (FMT) made from artificial yellow chrysanthemum flower coated with sticky material was originally developed to attract anthophilous Frankliniella thrips species. During evaluation of the FMT in a strawberry greenhouse, it was also found to attract higher number of greenhouse whitefly, Trialeurodes vaporariorum Westwood (Homoptera: Aleyrodidae), compared to the conventional yellow sticky trap. The color cue exhibited by the petals and/or geometrical pattern of the flower models might have tempted the whitefly to land on them. Therefore, we assessed the potential of the FMT as a novel pest management tactic for T. vaporariorum. In laboratory comparison test in an acryl cage, the FMT captured adult whiteflies 1.8 times more than did the yellow...
1785107528
Milk Production and Composition, Rumen Fermentation Parameters, and Grazing Behavior of Dairy Cows Supplemented with Different Forms and Amounts of Corn Grain
Journal of Dairy Science, 2000
The objectives were to compare milk production and composition, change in body weight and body condition score, rumen fermentation parameters and grazing patterns by cows when supplemented with different forms and amounts of corn grain. In experiment 1, 36 Holstein cows were supplemented with either 6, 6, 6, or 4 kg/d of dry matter of high moisture corn, coarsely ground corn, finely ground corn, or high moisture corn in two equal daily feedings, respectively. Milk yield (30.3 kg/d), milk protein (2.97%), and milk urea N (14.7 mg/dl) were not different among treatments. Body weight change and body condition score change were similar (23.1 kg and -0.24) for the 10-wk study. During experiment 2, four rumen cannulated cows in midlactation were supplemented with ...
1785107528
Collaborative configuration approaches in software product lines engineering: A systematic mapping study
Journal of Systems and Software, 2019
In the context of software product line engineering, collaborative configuration is a decision-making process where multiple stakeholders contribute in building a single product specification. Several approaches addressing collaboration during configuration have already been proposed, but we still have little hard evidence about their effectiveness and little understanding about how collaborative configuration process should be carried out. This paper presents a classification framework to help understand existing collaborative configuration approaches. To elaborate it, a systematic mapping study was conducted guided by three research questions and 41 primary studies was selected out of 238 identified ones. The proposed framework is composed of four dimensio...
1785107528
The Impact of Student Experiences on Progress in College: An Examination of Minority and Nonminority Differences
NASPA Journal, 2001
Although the literature has suggested that minority and nonminority students often have different experiences and perceptions of these experiences in college, the findings of this study suggest that the relationship between college experiences and progress are quite similar for the two groups. This finding reinforces the need to further explore how minority and nonminority students interpret their college experience and whether satisfaction with their college experience emanates from similar types of activities, relationships, and environments. Understanding this next component, especially as increasing numbers of minority students enroll in college, will unquestionably help colleges and universities to create an atmosphere and culture conducive to progress ...
1785107528
Synthesis and characterization of an azo dibenzoic acid Schiff base and its Ni(II), Pb(II), Zn(II) and Cd(II) complexes
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2013
The new Schiff base 4,4′-(1E,1′E)-(3,3′-(1E,1′E)-(pyridine-2,6-diylbis(azan-1-yl-1-ylid ene))bis(methan-1-yl-1-ylidene)bis(4-hydroxy-3,1-phenylene))bis(diazene-2,1-diyl)dibenzoic acid (1) was prepared from the condensation reaction of 2,6-diaminopyridine with 4-((3-formyl-4-hydroxyphenyl)diazenyl)benzoic acid in methanol. The compound 1 is potentially an N, O multidentate chelating ligand which could form stable complexes with metal ions in 1:1 up to 1:3 mol ratio of metal to ligand. The 1:1 complexes of Schiff base 1 with Ni(II), Pb(II), Zn(II) and Cd(II) have been synthesized by its condensation reaction with appropriate salts of metal ions. Structures of Schiff base (1) as well as its complexes with abovementioned metal ions were characterized by ...
1785107528
Molecular Design of Asymmetric Difluorinated Ether Electrolytes for Stable Operation of High‐Voltage Lithium Metal Batteries
Angew Chem Int Ed, 2025
Abstract Fluorination of electrolyte solvents is key to improving the cycling stability of high‐voltage lithium metal batteries (LMBs), yet the critical role of fluorinated alkyl chain length in governing solvation and interphase chemistries remains unclear. Herein, we systematically engineered a series of methoxy ethoxy methane derivatives with tailored fluorinated alkyl groups to screen the optimal asymmetric difluorinated electrolytes for high‐voltage LMBs. Spectroscopic and computational studies show that the ─CF 2 H group in difluoroethoxy methoxy methane (DFME) facilitates balanced Li─F interactions, which are essential for ensuring efficient ion transport and maintaining oxidation stability. In contrast, the elongated ─CF 2 CF 2 H group in t...
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Ticks (Acari: Ixodidae) Parasitizing Canines and Deer in Arkansas
Journal of Entomological Science, 2010
Increased occurrence of tick-borne diseases requires the surveillance of tick species associated with humans and the animals they contact. Tick species were collected from canines and deer throughout Arkansas by veterinarians during December 2006 to October 2007, while personnel with the Arkansas Game and Fish Commission collected ticks from hunter-killed deer throughout the 2007 hunting season (Oct-Dec). Five tick species were collected: Ixodes scapularis Say (51%), Amblyomma americanum (L.) (22%), Rhipicephalus sanguineus (Latreille) (12%), A. maculatum (Koch) (7%), Dermacentor variabilis (Say) (6%), and unidentified Amblyomma species (2%). Tick collections from canines were A. americanum (45%), whereas 89% of ticks collected from deer were I. scapularis. ...
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Patient Care and Daily Stress Among Emergency Medical Technicians
Prehosp. Disaster med., 1996
Abstract Introduction: There is conflicting research regarding the extent to which patient care is a source of stress for emergency medical technicians (EMTs). Some research indicates that it is important, whereas other studies suggest that it takes a “back seat” to administrative and organizational problems. This study sought to explore this issue further by investigating the relationship between caring for patients, daily workday stress, and daily nonworkday stress among EMTs. Methods: All EMTs employed by East Baton Rouge Parish Emergency Medical Services were eligible for participation. After the study was described, subjects completed a demographic information sheet and informed consent was obtained. Participants then completed 30 days of monitoring...
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Immunthrombozytopenische Purpura und letale zerebrale Blutung als unerwünschte Wirkung von Furosemid
Praxis, 2004
Ein 74-jähriger Patient wird wegen progressiv verlaufender Purpura hospitalisiert. 18 Monate zuvor hatte er bei koronarer Herzkrankheit einen AC-Bypass erhalten. Wegen linksventrikulärer Herzinsuffizienz wurde ihm nun 14 Tage vor Eintritt Furosemid verschrieben, welches er alternierend einnahm. Laborchemisch konnte eine schwere Thrombozytopenie diagnostiziert werden. Trotz unmittelbarem Einsatz von Prednisolon i.v. und Plättchentransfusionen erlag er innerhalb weniger Stunden einer schweren intrazerebralen Blutung. Die Autopsie bestätigte eine diffuse hämorrhagische Diathese und zeigte eine zelluläre Reaktion im Knochenmark vereinbar mit einer akuten Immunreaktion. Die Manifestation einer Purpura neun bis zehn Tage nach Einnahme der ersten Dosis Furose...
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un–au Partnerships in International Peace and Security and Issues of Responsibility Allocation in Cases of un Support to Regional Missions
Int Organ Law Rev, 2016
In the last decade, the United Nations and the African Union have forged a close partnership in matters of international peace and security. This article attempts to shed light on the multifaceted role of the un in the strategic and operational planning and evolution, as well as the funding, of regional (African Union) peace support operations. Such involvement goes well beyond a simple authorization by the un Security Council and raises crucial questions in respect of the allocation of responsibility between the un and the African Union. The analysis of the relevant responsibility allocation clauses showcases that a holistic approach should be adopted that does not micromanage the different aspects of the un involvement in regional missions, but treats them...
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Effects of Storage Temperature on Properties of Evaporated Milk
Journal of Dairy Science, 1951
Summary Quantitative determination of the deterioration of evaporated milk during storage showed that the pH and viscosity decrease and the color increases with an increase in the temperature of storage. Commercial evaporated milk of heavy body remained acceptable for 2 yr. when held in undisturbed storage below 60° F. Physical deterioration was rapid during storage above 70°. Determination of the reaction of evaporated milk afforded a means for evaluating its previous storage conditions. The reaction of fresh evaporated milk was about pH 6.1. The product remained of good quality until the reaction became more acid than pH 6.0. The product was unacceptable when it was more acid than pH 5.9. Separation of fat and protein in a commercial evaporated milk of h...
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The Clinical Efficacy and Safety of Galantamine in the Treatment of Alzheimer's Disease
CNS spectr., 2004
Abstract Alzheimer's disease is a progressive, neurodegenerative condition characterized by deficits in cognition, inability to perform activities of daily living, and alterations in behavior. Galantamine hydrobromide is the newest acetylcholin esterase inhibitor (AChEI) approved in the United State for the treatment of mild-to-moderate AD. The safety and efficacy of galantamine has been demonstrated in multiple randomized, Phase III trials of > 2,600 patients with mild-to-moderate AD. Studies have found that galantamine improved or maintained performance in all domains of AD (cognition, function, behavior, and caregiver burden in the short term and slowed the decline in performance or maintained baseline performance through 12 months. The dual mechanism ...
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Determination of piceid in rat plasma and tissues by high‐performance liquid chromatographic method with UV detection
Biomedical Chromatography, 2006
A rapid, sensitive and selective HPLC method was developed and validated for determination of piceid in rat plasma and tissues. The drug was isolated from plasma and tissues by a simple protein precipitation procedure. Chromatographic separation was performed on a C18 column with acetonitrile-water (26:74, v/v) as mobile phase. The method was successfully applied to the pharmacokinetics and tissue distribution research after oral administration of a 50 mg/kg dose of piceid to healthy male Wistar rats. The pharmacokinetic parameters showed that piceid was quickly absorbed, distributed and eliminated within 4 h after oral administration. The tissue distribution results showed that, at 10 min, the concentrations of piceid in most tissues reached peak level exce...
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Pressurized liquid extraction–capillary electrophoresis–mass spectrometry for the analysis of polar antioxidants in rosemary extracts
Journal of Chromatography A, 2005
A method based on capillary electrophoresis-electrospray-mass spectrometry (CE-ESI-MS) was developed to qualitatively characterize natural antioxidants from rosemary (Rosmarinus officinalis L.) in different fractions obtained by pressurized liquid extraction (PLE) using subcritical water. The parameters of CE-ESI-MS were adjusted allowing the separation and characterization of different compounds from rosemary in the PLE fractions. These parameters for CE are kind, pH and concentration of the separation buffer, parameters for ESI-MS are dry gas temperature and flow, nebulizing gas pressure, and make-up flow. The following analytical conditions were found most favorable: aqueous CE buffer (40 mM ammonium acetate/ammonium hydroxide, pH 9); sheath liquid contai...
1785107527
Effectiveness of the Kids in Control of Food (KICk–OFF) structured education course for 11–16 year olds with Type 1 diabetes
Diabet. Med., 2015
To assess the effect of a 5-day structured education course (Kids in Control of Food; KICk-OFF) on biomedical and psychological outcomes in young people with Type 1 diabetes.This was a cluster-randomized trial involving 31 UK paediatric centres. Participants were recruited prior to stratified centre randomization. Intervention centres delivered KICk-OFF courses, whereas control centres delivered usual care. Participants were 11-16 years of age and had Type 1 diabetes for at least one year. The KICk-OFF course was delivered by trained educators to eight participants per course. Glycaemic control and quality of life were measured at baseline, 6, 12 and 24 months. Secondary outcomes were hypoglycaemia, ketoacidosis, fear of hypoglycaemia and diabetes self-effic...
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Characterization and Low-Resolution Structure of an Extremely Thermostable Esterase of Potential Biotechnological Interest from Pyrococcus furiosus
Mol Biotechnol, 2016
Enzymes isolated from extremophiles often exhibit superior performance and potential industrial applications. There are several advantages performing biocatalysis at elevated temperatures, including enhanced reaction rates, increased substrate solubility and decreased risks of contamination. Furthermore, thermophilic enzymes usually exhibit high resistance against many organic solvents and detergents, and are also more resistant to proteolytic attack. In this study, we subcloned and characterized an esterase from the hyperthermophilic archaeon Pyrococcus furiosus (Pf_Est) that exhibits optimal activity around 80 °C using naphthol-derived substrates and p-nitrophenyl palmitate (pNPP). According to the circular dichroism spectra, the secondary structure of P....
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Arthroscopically assisted mini-open rotator cuff repair
Arthroscopy: The Journal of Arthroscopic & Related Surgery, 2002
Purpose: To review the results of arthroscopically assisted mini-open rotator cuff repair. Type of Study: Retrospective clinical review. Methods: From 1990 to 1994, 67 patients (69 shoulders) had a rotator cuff repair for a full-thickness tear; 63 of these patients had an arthroscopically assisted mini-open rotator cuff repair. Of these, 22 were lost to follow-up; thus, 41 patients were retrospectively reviewed for this study. The average patient age was 51 years and the average follow-up was 36 months. UCLA scores incorporating preoperative and postoperative pain, function, strength, and range of motion data were used to analyze the results. Results: At follow-up, 38 patients (93%) were rated as excellent or good, 3 patients (7%) were rated as fair, and non...
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Leveraging mobile devices for human resource information systems
IJBIS, 2015
Finding ways to engage with workers will help address the challenges of a global, flexible and remote workforce. There is a strong need for improved employee engagement, fostered by creative solutions with new human resource practices and approaches that have global application, but, local implications. These challenges will be addressed by using enabling technologies, in this paper. The objective of the work presented in this paper was to leverage mobile devices for human resource information systems. The paper first demonstrates the shift from desktop to web-based applications. It then proceeds to list the factors in the adoption of cellphone applications in organisations. Next, it proceeds to identify the key players and their roles and description. It al...
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The theory of VLF Doppler signatures and their relation to magnetospheric density structure
J. Geophys. Res., 1976
The published spectrograms of signals from ground-based VLF transmitters observed aboard satellites show a wide variation from sample to sample. In general, the observed signals are Doppler shifted by the motion of the satellite, but in some published samples there is no observed Doppler shift. A ray tracing study of differing VLF Doppler signatures observed by the Ogo 4, FR 1, and Isis 2 VLF experiments has shown that each signature can be reproduced by a distinct class of electron density gradient models. Large positive and negative Doppler shifts (∼100 Hz) are reproduced by a strong decreasing electron density gradient which interacts with the magnetic field curvature gradient between L ∼ 2 and L ∼ 3. Presence of a strong signal with no Doppler shif...
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Hydraulic conditioning to manage potable water discolouration
Proceedings of the Institution of Civil Engineers - Water Management, 2019
Results are reported from studies conducted using a unique laboratory-based, full-scale, temperature-controlled pipe facility to examine the impact of conditioning shear stress on discolouration risk, as characterised by bulk water samples (turbidity, iron and manganese) and biofilm pipe wall measurements. The facility uniquely allowed for replication of the dynamics of an operational network but with rigorous control, thus yielding fully representative results overcoming the limitations of bench-scale or operational studies. The effect of the daily variation in flow (and boundary shear stress) was observed to be greater than the effect of the average daily flow rate at reducing discolouration risk. This is useful for informing operation and maintenance stra...
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Nucleosome positioning and histone modifications define relationships between regulatory elements and nearby gene expression in breast epithelial cells
BMC Genomics, 2014
The precise nature of how cell type specific chromatin structures at enhancer sites affect gene expression is largely unknown. Here we identified cell type specific enhancers coupled with gene expression in two different types of breast epithelial cells, HMEC (normal breast epithelial cells) and MDAMB231 (triple negative breast cancer cell line). Enhancers were defined by modified neighboring histones [using chromatin immunoprecipitation followed by sequencing (ChIP-seq)] and nucleosome depletion [using formaldehyde-assisted isolation of regulatory elements followed by sequencing (FAIRE-seq)]. Histone modifications at enhancers were related to the expression levels of nearby genes up to 750 kb away. These expression levels were correlated with enhancer statu...
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The effect of forced ventilation by using two movable fans on thermal smoke movement in a tunnel fire
Journal of Wind Engineering and Industrial Aerodynamics, 2019
In this work, tests were conducted to investigate the propagation characteristics of buoyancy-driven thermal smoke for different multiple movable fan layouts in a full-scale road tunnel. The temperatures along the longitudinal direction of the tunnel ceiling upstream and downstream of the fire source were measured and the thermal smoke development was recorded using the laser sheet visualization technique. The spread velocity and descent velocity were derived based on the longitudinal and vertical temperature distributions in order to analyze the differences in thermal smoke propagation for various movable fan layouts. The results showed that the best configuration, which gives the highest reduction of maximum temperature and enhanced propagation of thermal ...
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Armigeres subalbatus incriminated as a vector of zoonotic Brugia pahangi filariasis in suburban Kuala Lumpur, Peninsular Malaysia
Parasites Vectors, 2013
Abstract Background In 2011, we reported occurrence of natural human infections with Brugia pahangi , a filarial worm of dogs and cats, in a surburb of Kuala Lumpur, the capital city of Malaysia. Our preliminary entomological survey at that time suggested the mosquito species Armigeres subalbatus as the vector of the zoonotic infections. In this present report, we provide biological evidence to confirm our preliminary finding. Findings A total of 1798 adult female Ar. subalbatus mosquitoes was caught in the vicinity of the suburb, and 1599 were dissected for the presence of filarial larvae. Sixty-two mosquitoes were positive, and 27 of these were infected with L 3 larvae . The L 3 were inoculated into male gerbils. Microfilariae could be detected in the gerb...
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Process–property–structure relationship in miniaturized injection moulded polyoxymethylene samples
Polymer Engineering & Sci, 2013
Micro-injection moulding is one of the key manufacturing technologies for thermoplastic polymeric materials for the mass production of high value miniaturized components. However, this process is not just a straightforward down scaling of the conventional injection moulding technique. Indeed, during the micro-injection the polymer melt is forced to flow at high strain rates through very small channels in nonisothermal conditions; this can lead to complex microstructures and to parts with unexpected performances. In this work, the relationships among the processing conditions, the mechanical properties and the microstructural characteristics of polyoxymethylene miniaturized specimens obtained by injection moulding were investigated. The attention was focused ...
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Correlation of erythrocyte and plasma levels of zinc, copper, and iron with evidence of metastatic spread in cancer patients
Cancer, 1985
The level of plasma copper (Cu-PI) and zinc (Zn-Pl) and the level of erythrocyte iron (Fe-RBC), copper (Cu-RBC), and zinc (Zn-RBC) were determined in the blood of 70 normal donors and 138 patients with various solid tumors by diagnostic x-ray spectrometry (DXS), a technique based on x-ray fluorescence spectrometry analysis. There were no significant changes in the mean values of Zn-Pl, Fe-RBC, and Cu-RBC in the patients when compared with those of normal donors. The mean level of Cu-PI in the normal donors was 1.34 ± 0.37 μg/ml; it was significantly increased in the patients, ranging between 1.47 ± 0.34 μg/ml for patients without evidence of active cancer (NED) and 1.91 ± 0.76 μg/ml for patients with hepatic metastases. The most significant change obse...
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High‐density photoautotrophic algal cultures: Design, construction, and operation of a novel photobioreactor system
Biotech & Bioengineering, 1991
A photobioreactor system has been designed, constructed and implemented to achieve high photosynthetic rates in high-density photoautotrophic algal cell suspensions. This unit is designed for efficient oxygen and biomass production rates, and it also can be used for the production of secreted products. A fiber-optic based optical transmission system that is coupled to an internal light distribution system illuminates the culture volume uniformly, at light intensities of 1.7 mW/cm(2) over a specific surface area of 3.2 cm(2)/cm(3). Uniform light distribution is achieved throughout the reactor without interfering with the flow pattern required to keep the cells in suspension. An on-line ultrafiltration unit exchanges spent with fresh medium, and its use result...
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Amygdala Activation During Emotion Processing of Neutral Faces in Children With Severe Mood Dysregulation Versus ADHD or Bipolar Disorder
AJP, 2010
Objective To understand disorder-unique and common pathophysiology, studies in multiple patient groups with overlapping symptoms are needed. Deficits in emotion processing and hyperarousal symptoms are prominent features of bipolar disorder, attention deficit hyperactivity disorder (ADHD), and severe mood dysregulation. The authors compared amygdala response during emotional and nonemotional ratings of neutral faces in youths with these disorders as well as a group of healthy comparison youths. Method Blood-oxygen-level-dependent (BOLD) signal in the amygdala was examined in children with bipolar disorder (N=43), ADHD (N=18), and severe mood dysregulation (N=29) and healthy comparison subjects (N=37). During functional magnetic resonance imaging (fMRI), part...
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URETERAL ENDOMETRIOSIS DIAGNOSED AT URETEROSCOPY
Obstetrics & Gynecology, 1998
In Brief Background Intrinsic ureteral endometriosis is rare. Early detection and treatment is extremely important to preserve renal function. Case A 37-year-old woman with right flank pain was diagnosed with a polypoid lesion at excretory urogram. The polyp was removed under ureteroscopy and was found to be endometriosis. Subsequent exploratory laparotomy and ureterolysis failed to document other foci of endometriosis. Resection of the ureter was not needed. She received medroxyprogesterone for 6 months, and a ureteral stent was left in place for 3 months postoperatively. Excretory urogram showed no obstruction 6 months postoperatively. Conclusion This appears to be the first reported case of ureteral endometriosis documented initially at ureteroscopy. Prom...
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“First proposed panels on acute leukemia for four-color immunophenotyping by flow cytometry from the Brazilian Group of Flow Cytometry - GBCFLUX”
Cytometry, 2014
Multiparameter flow cytometry (MFC) is a highly sensitive, fast and specific diagnostic technology with a wide range of applicability in hematology. Although well-established eight-color immunophenotyping panels are already available, most Brazilian clinical laboratories are equipped with four-color flow cytometer facilities. Based on this fact, the Brazilian Group of Flow Cytometry (Grupo Brasileiro de Citometria de Fluxo, GBCFLUX) for standardization of clinical flow cytometry has proposed an antibody panel designed to allow precise diagnosis and characterization of acute leukemia (AL) within resource-restricted areas. Morphological analysis of bone marrow smears, together with the screening panel, is mandatory for the primary identification of AL. The dis...
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Genome-Informed Recombinase Polymerase Amplification Assay Coupled with a Lateral Flow Device for In-Field Detection of Dickeya Species
Plant Disease, 2020
Dickeya spp. cause blackleg and soft rot diseases of potato and several other plant species worldwide, resulting in high economic losses. Rapid detection and identification of the pathogen is essential for facilitating efficient disease management. Our aim in this research was to develop a rapid and field-deployable recombinase polymerase amplification (RPA) assay coupled with a lateral flow device (LFD) that will accurately detect Dickeya spp. in infected plant tissues without the need for DNA isolation. A unique genomic region (mglA/mglC genes) conserved among Dickeya spp. was used to design highly specific robust primers and probes for an RPA assay. Assay specificity was validated with 34 representative strains from all Dickeya spp. and 24 strains from ot...
1785107526
New approach for the design of an optical square pulse generator
Appl. Opt., 2007
What is believed to be a new approach for the design and analysis of a reconfigurable optical square pulse generator using the concept of temporal optical integration and the digital signal processing method is presented. The reconfigurable square pulse generator is synthesized using compact active semiconductor-based waveguide technology, and it consists simply of the cascade of a tunable microring resonator (or a tunable all-pole filter) and a tunable asymmetrical Mach-Zehnder interferometer (or a tunable all-zero filter). The reconfigurable generator can convert an input picosecond pulse (i.e., soliton or Gaussian pulse) into an optical square pulse. The pulse width of the generated square pulse can be adjusted by controlling the time delay of a variable ...
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Comparison of Two Therapy Approaches in the Rehabilitation of the Pure Motor Hemiparetic Stroke Patient
Neurorehabilitation and Neural Repair, 1995
Although there are a variety of therapeutic philosophies applied in stroke rehabilitation, it has not been determined whether one approach is superior to another. We prospectively evaluated twenty-seven patients with pure motor hemiparetic strokes admitted to an acute neurorehabilitation unit and randomized them to treatment with either a traditional functional retraining approach (TFR) or neurodevelopmental techniques (NDT). NDT and TFR treated patients did not differ with regard to age, gender, side of stroke, or days from stroke to study entry. Other than an increased gait velocity in NDT treated patients at hospital discharge (p = 0.04), there was no significant difference in gait measures, upper extremity motor skills, or Functional Independence Measure...
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Ebola Virion Attachment and Entry into Human Macrophages Profoundly Effects Early Cellular Gene Expression
PLoS Negl Trop Dis, 2011
Zaire ebolavirus (ZEBOV) infections are associated with high lethality in primates. ZEBOV primarily targets mononuclear phagocytes, which are activated upon infection and secrete mediators believed to trigger initial stages of pathogenesis. The characterization of the responses of target cells to ZEBOV infection may therefore not only further understanding of pathogenesis but also suggest possible points of therapeutic intervention. Gene expression profiles of primary human macrophages exposed to ZEBOV were determined using DNA microarrays and quantitative PCR to gain insight into the cellular response immediately after cell entry. Significant changes in mRNA concentrations encoding for 88 cellular proteins were observed. Most of these proteins have not yet ...
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Frequent Travelers and Rate of Spread of Epidemics
Emerg. Infect. Dis., 2007
A small proportion of air travelers make disproportionately more journeys than the rest of travelers. They also tend to interact predominantly with other frequent travelers in hotels and airport lounges. This group has the potential to accelerate global spread of infectious respiratory diseases. Using an epidemiologic model, we simulated exportation of cases from severe acute respiratory syndrome-like and influenza-like epidemics in a population for which a small proportion travel more frequently than the rest. Our simulations show that frequent travelers accelerate international spread of epidemics only if they are infected early in an outbreak and the outbreak does not expand rapidly. If the epidemic growth rate is high, as is likely for pandemic influenza...
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Phenylalanine ab initio models for the simulation of skin natural moisturizing factor
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2013
In this study, we evaluated models that can be used to simulate amino acids in biological environments via density functional theory (DFT). The goal was to obtain realistic representations that combine computational economy and result quality when compared to experimental data. We increased the complexity of the models by using a model of an amino acid in a vacuum, followed by a water-solvated amino acid model. To consider pH variation, we simulated zwitterionic and nonionic amino acid configurations. The amino acid chosen for testing was phenylalanine, an aromatic amino acid present in high concentrations in the natural moisturizing factor of skin that plays a fundamental role in ultraviolet protection and vitiligo disease. To validate the models, vibration...
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Evolving Strategies for the Management of Atrial Fibrillation
JAMA, 1992
Management strategies for the most common sustained cardiac arrhythmia,1,2atrial fibrillation, have undergone considerable evolution over the last several years. The objectives of therapy are to slow ventricular rate and restore and maintain sinus rhythm. Prevention of symptoms and reduction in the risk of complications such as stroke are therapeutic goals with agents that slow atrioventricular nodal conduction, antiarrhythmic agents, and anticoagulants. The utility of digoxin for rate control has been questioned with recent studies suggesting that this former mainstay of therapy may now play a subsidiary role.3β-Blockers and calcium channel blockers are now frequently used for slowing ventricular response. Concerns regarding the safet...
1785107525
α-Amino Acids as Synthons in the Ugi-5-Centers-4-Components Reaction: Chemistry and Applications
Symmetry, 2019
Since the first reports, the Ugi four-component reaction (U-4CR) has been recognized as a keystone transformation enabling the synthesis of peptide mimetics in a single step and with high atom economy. In recent decades, the U-4CR has been a source of inspiration for many chemists fascinated by the possibility of identifying new efficient organic reactions by simply changing one of the components or by coupling in tandem the multicomponent process with a huge variety of organic transformations. Herein we review the synthetic potentialities, the boundaries, and the applications of the U-4CR involving α-amino acids, where the presence of two functional groups—the amino and the carboxylic acids—allowed a 5-center 4-component Ugi-like reaction, a powerful t...
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Identification and characterization of two new types of bacterial l-serine dehydratases and assessment of the function of the ACT domain
Archives of Biochemistry and Biophysics, 2013
Two new types of bacterial Fe-S L-serine dehydratases have been identified. These join two previously recognized enzyme types, for a total of four, that are distinguished on the basis of domain arrangement and amino acid sequence. A Type 3 enzyme from Amphibacillus xylanus (axLSD) and a Type 4 enzyme from Heliscomenobacter hydrossis (hhLSD) were cloned, expressed, purified, and characterized. Like the Type 1 enzyme from Bacillus subtilis (bsLSD), axLSD required a monovalent cation, preferably potassium, for activity. However, the hhLSD was without activity even after reconstitution of the iron-sulfur center by a process that successfully restored activity to oxygen-inactivated axLSD. This and other characteristics suggest that this Type 4 protein may be a ps...
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An Institutional Theory of Organizational Communication
Commun Theory, 2006
For many years, reviewers have argued that organizational communication research is overly concentrated on microphenomena to the neglect of macrophenomena, but macrophenomena have generally remained unspecified. An institutional theory of organizational communication is proposed to fill that gap. Drawing on institutional theory in organizational sociology and on concerns in organizational communication, we define institutions as constellations (i.e., relatively fixed arrangements) of formalized rational beliefs manifested in individuals’ organizing behaviors. Key concepts for the analysis of institutions include membership, rational myths, isomorphism, and decision hierarchies. Based on our definition and armed with these concepts, the paper formally speci...
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Highly Selective Vagotomy in Duodenal Ulceration and its Complications
Annals of Surgery, 1984
Highly selective vagotomy (HSV) was performed in 509 patients over 12 years for the surgical management of duodenal ulceration; 103 HSVs were carried out during the treatment of complications. The overall rate of ulcer recurrence was 7%, ranging from 10% in the first 4 years to 4% in the 6 years between 1975 and 1980. Highly selective vagotomy was performed in addition to closure of a perforated ulcer in 16 patients, with no recurrent ulcers or re-perforations. After the control of their bleeding duodenal ulcers, 25 patients had HSV with no rebleeding, although two patients had recurrent ulceration. Highly selective vagotomy was performed in 62 patients with stenosis in addition to dilatation (44) or duodenoplasty (18). There was a high incidence of recurren...
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Civil Religion and the History of Democratic Modernity: Probing the Limits of the Sacred and the Secular
Religion Compass, 2010
The aim of this essay is to introduce readers to recent work on the concept of ‘civil religion’, what might be regarded as the democratic variant of political religion. Ever since 1967, when the sociologist Robert Bellah published his article ‘Civil Religion in America’, the concept has been the subject of intense debate and ongoing refinement. The essay reviews the recent contributions of Marcela Cristi and Emilio Gentile. However, it also seeks to introduce readers to some old and recent work on the history of democratic modernity (including Charles Taylor’s A Secular Age), which, it is argued, represents an alternative way of thinking about the sacred dimensions of ostensibly secular national republics. Given the increasing tendency to question ...
1785107524
Nutritional Requirements for Sustaining Health and Performance During Exposure to Extreme Environments
Annu. Rev. Nutr., 2020
Dietary guidelines are formulated to meet minimum nutrient requirements, which prevent deficiencies and maintain health, growth, development, and function. These guidelines can be inadequate and contribute to disrupted homeostasis, lean body mass loss, and deteriorated performance in individuals who are working long, arduous hours with limited access to food in environmentally challenging locations. Environmental extremes can elicit physiological adjustments that alone alter nutrition requirements by upregulating energy expenditure, altering substrate metabolism, and accelerating body water and muscle protein loss. The mechanisms by which the environment, including high-altitude, heat, and cold exposure, alters nutrition requirements have been studied extens...
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Optimal allocation of energy storage systems considering wind power uncertainty
Journal of Energy Storage, 2018
Abstract Energy storage systems (ESSs) play a major role in power system planning and operation. As evolution of the storage technologies continues, planners will be regarded the ESSs in future power systems more than ever. Simultaneous determination of size and site of ESSs is a non-deterministic, and non-convex problem, which should take into account the uncertain nature of today's power systems. This paper, for the first time, investigates uncertain optimal allocation of ESSs considering practical constraints, including prohibited zones, and ramp rate, as well as simultaneous reduction of three different and incompatible objective functions of operation cost, voltage deviation, and air emission. Due to complexity of the problem, two multi-objective hybrid...
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Taste Responses to Sweet Stimuli in -Gustducin Knockout and Wild-Type Mice
Chemical Senses, 2006
The importance of alpha-gustducin in sweet taste transduction is based on data obtained with sucrose and the artificial sweetener SC45647. Here we studied the role of alpha-gustducin in sweet taste. We compared the behavioral and electrophysiological responses of alpha-gustducin knockout (KO) and wild-type (WT) mice to 11 different sweeteners, representing carbohydrates, artificial sweeteners, and sweet amino acids. In behavioral experiments, over 48-h preference ratios were measured in two-bottle preference tests. In electrophysiological experiments, integrated responses of chorda tympani (CT) and glossopharyngeal (NG) nerves were recorded. We found that preference ratios of the KO mice were significantly lower than those of WT for acesulfame-K, dulcin, fru...
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Metastrategy: Learning and avoiding past mistakes
Long Range Planning, 1997
Lately there has been a renewed interest in strategic planning’ after more than a decade of focusing on operational concerns such as total quality, downsizing, benchmarking and reengineering. Will strategic planning provide any real benefits to firms this time or will it prove another fad?’ After all it is only a couple of years since the rise and fall of strategic planning was well-documented.3 While there is no doubt that strategy is indispensable for the success of firms, countries, or even whole continents like Europe, there is little agreement even on what strategy is,4 not to mention what must be done to improve the chances of succeeding in the future. This article looks at past practices in the field of strategy which have, in their great majority...
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Patterns and Trends of Herbal Medicine Use among Patients with Gynecologic Cancer
Geburtshilfe Frauenheilkd, 2021
Abstract Background More and more information about complementary and integrative medicine is becoming available, especially among cancer patients. However, little is known about the use of herbal medicine by patients with gynecologic cancers. This study aimed to assess the use of herbal products by gynecologic cancer patients compared with healthy controls. Methods This cross-sectional study was conducted at the Department for Gynecology and Obstetrics of Erlangen University Hospital and included 201 patients with gynecologic cancer and 212 healthy controls. Use of herbal medicines was evaluated using a standardized questionnaire. Medical information on cancer patients was collected from hospital records. Group comparisons were done using a logistic regress...
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An empirical investigation of the National Innovation System (NIS) using Data Envelopment Analysis (DEA) and the TOBIT model
International Review of Applied Economics, 2014
The goal of this paper is to investigate national innovation systems’ input–output components and to model a robust efficiency measurement using the DEA Bootstrap technique. Most of the previous NIS studies are descriptive and little emphasis is given to complex analysis. In our previous study, we evaluated the innovation performance of 20 emerging and developed countries, from the point of view of technical efficiency. This study makes an important contribution using the DEA Bootstrap technique, whereby we rank the countries based on bias-corrected estimation parallel to conventional DEA efficiency. The efficiency scores obtained from this technique show which countries are considered to be innovation leaders because their innovation performance is effi...
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Morphologic characteristics of benign and malignant adrenocortical tumors
Cancer, 1985
Differentiation between benign and malignant tumors of the adrenal cortex was studied by means of seven histologic parameters. Each separate criterion was significantly different in two groups, one consisting of patients without metastases within 10 years after operation and one of patients with metastatic tumors. Discrimination on the basis of single parameters in individual patients, however, was of little value. When a histologic index was calculated using the same parameters but after “weighing,” a much better discrimination was obtained. The histologic index and, to a lesser degree, the mitotic activity seems to be related to the survival time of the patients with adrenal cortical carcinoma. The authors conclude that the calculation of a histologic ...
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Survey on Visualization and Visual Analytics pipeline-based models: Conceptual aspects, comparative studies and challenges
Computer Science Review, 2020
In the last decade, many studies have focused on visualization. The main key to make it practical for research and engineering applications is the suitable definition of a pipeline-based visualization model. It provides effective abstractions for designing visualization tools. In this article, we present a comprehensive survey on pipeline-based models for Information Visualization. The basic principles of visualization models and processes are reviewed in literature as proposed in the original versions and their different revisions. Their significant extensions are grouped into two main categories: Information Visualization process and Visual Analytics process. We propose three summaries: The first one focuses on the conceptual aspects; the second one compar...
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Paediatric cerebral sinus vein thrombosis
Thromb Haemost, 2004
Summary The etiology and pathophysiology of cerebral sinus venous thrombosis (CSVT) in the paediatric population is still poorly understood, and the role of thrombophilic risk factors remains to be elucidated. In our multi-center case-controlled study we studied 46 patients with CSVT diagnosed from April 1996 to December 2003, consecutively referred for thrombophilia work-up. The results of thrombophilia screen were compared to 112 healthy paediatric controls. Anticoagulant therapy was applied according to treating physicians’ decisions, and all cases were prospectively followed for a median of 4.1 years. Of 46 children, 8 had CSVT diagnosed in the neonatal period and therefore were analyzed separately. The prevalence of single thrombophilia markers and co...
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Mutational activation of the
RocR
activator and of a cryptic
rocDEF
promoter bypass loss of the initial steps of proline biosynthesis in
B
acillus subtilis
Environmental Microbiology, 2013
The gamma-glutamyl-phosphate reductase (ProA) interlinks both the anabolic and osmostress adaptive proline biosynthetic routes of Bacillus subtilis. Because no paralogous protein to ProA exists in this microorganism, proA mutants should exhibit a tight proline auxotrophic growth phenotype. Contrary to expectations, proA mutants formed microcolonies on agar plates lacking proline and faster growing Pro+ suppressor mutants arose. These mutants carried alterations in the rocR-rocDEF region encoding enzymes of the arginine degradation pathway and its transcriptional activator RocR. They were of two types: (i) mutants carrying single amino acid substitutions in RocR resulting in partial inducer-independent variants and (ii) mutants carrying single base-pair chang...
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Desingularizations of the moduli space of rank 2 bundles over a curve
Math. Ann., 2004
Let X be a smooth projective curve of genus g≥3 and M0 be the moduli space of rank 2 semistable bundles over X with trivial determinant. There are three desingularizations of this singular moduli space constructed by Narasimhan-Ramanan [NR78], Seshadri [Ses77] and Kirwan [Kir86b] respectively. The relationship between them has not been understood so far. The purpose of this paper is to show that there is a morphism from Kirwan’s desingularization to Seshadri’s, which turns out to be the composition of two blow-downs. In doing so, we will show that the singularities of M0 are terminal and the plurigenera are all trivial. As an application, we compute the Betti numbers of the cohomology of Seshadri’s desingularization in all degrees. This generalizes t...
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Changes in Intervertebral Disk Dimensions After a Loading Task and the Relationship With Stature Change Measurements
Archives of Physical Medicine and Rehabilitation, 2009
Lewis SE, Fowler NE. Changes in intervertebral disk dimensions after a loading task and the relationship with stature change measurements.To test the hypothesis that there would be a linear relationship between overall stature change determined by stadiometry and markers of lumbar disk height loss determined from magnetic resonance imaging (MRI).The short-term loading response of the lumbar spine was evaluated with both stadiometry and MRI, using a within-subject repeated-measures design. Measures were obtained both before and after 15 minutes of walking wearing a weighted vest (20% of body mass). Stature loss measured on the stadiometer was compared with change in lumbar spine length assessed from the MRI images.A university laboratory.Participants (N=13; m...