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FreeGee is an integrated application framework for Python and C++. Included modules are: Python (scripting), PostgreSQL (database), wxWidgets/wxWindows (GUI), GnuPG (crypto), omniORB (OO middleware), Apache (Web), and other fine tools (see Home Page).
pynotes is a wrapper around the Lotus Notes C Api that is needed to access Lotus Notes databases with Python. Other possibilities for this are the COM (windows only) and IIOP (Corba) bindings that can be used together with com/corba libraries for python.