Best ELN Software in the USA
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Compare the Top ELN Software in the USA as of November 2025
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What is ELN Software in the USA?
Electronic lab notebook (ELN) software provides researchers with the tools to optimize data collection and storage, transcription processes, information placement, and analysis operations. Compare and read user reviews of the best ELN software in the USA currently available using the table below. This list is updated regularly.
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1
LabWare LIMS
LabWare
14,000 laboratories. 125 countries. 98% customer satisfaction! Improve your lab's productivity, throughput, efficiency, data integrity, and compliance with LabWare's suite of laboratory automation solutions. LabWare offers flexible deployment options. Laboratories who are eager to deploy within 30 days can choose the cost-optimized + fully validated SaaS LIMS that contains best practice workflows. Laboratories that need a fully customizable enterprise-level LIMS/ELN can choose between flexible cloud or self-hosted deployment options. LabWare users enjoy world class features such as: lot management, sample management, stability management, environmental monitoring, instrument interfacing, workflows and dashboards, inventory management, COAs, barcoding, and much more! -
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eLabNext
eLabNext
eLabNext is dedicated to transforming laboratories worldwide with innovative digital solutions. We offer a comprehensive Digital Lab Platform (DLP), which integrates the Electronic Lab Notebook (ELN), Laboratory Information Management Systems (LIMS), machine learning, and AI. Our platform is designed to seamlessly integrate with your lab’s equipment and software, offering flexibility, security, and exceptional efficiency. By centralizing and optimizing all your research and process development workflows in a compliant environment, we empower researchers to focus on making ground-breaking discoveries. Our team of lab digitalization specialists is here to support you throughout your digitalization journey. eLabNext is a brand of Bio-ITech BV, part of Eppendorf Group. -
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Lockbox LIMS
Third Wave Analytics
A sample tracking, test result capture, and inventory management cloud LIMS for life science research, biotech/NGS, and industrial QC labs. Includes regulatory support for CLIA, HIPAA, Part 11, and ISO 17025. Nothing is more critical to a lab’s success than the quality, security, and traceability of samples. The Lockbox LIMS system provides robust sample management functionality to laboratory professionals, giving them full visibility on every aspect of a sample’s journey, from accessioning to long-term storage. LIMS analysis is about more than just tracking results- Lockbox’s multi-layered sample storage and location management functionality allows you to define your lab’s storage framework using a variety of location options: rooms, storage units, shelves, racks, boxes, and positions.Starting Price: $175/user/month -
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WeLIMS
WeLIMS
WeLIMS is the LIMS for small companies. Small companies might not have the budget for a LIMS but they still need to be organized and efficient in the Quality Control area. WeLIMS is a simple and efficient LIMS or Quality Control software. WeLIMS contains all you need to get started right now! Methods Management, Product Management, and Quality Control. You can say goodbye to your Notebooks and Excel spreadsheets! WeLIMS will take care of maintaining your product data and your QC data safely! With WeLIMS you can set the right level of authorization in your organization. Predefined roles for Product specifications management, Recipes management or Quality Control are already set up. Workflows make everyone collaborate efficiently and seamlessly.Starting Price: $30/month/user -
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Sapio Sciences
Sapio Sciences
Sapio Sciences' mission is to improve lives by accelerating discovery, and because science is complex, Sapio makes technology simple. Sapio is a global business offering an all-in-one science-awareTM lab informatics platform combining cloud-based LIMS, ELN, and the Sapio Scientific Data Cloud. Sapio serves some of the largest global and specialist brands, including biopharma, CRO/CDMOs, and clinical diagnostic labs across NGS genomic sequencing, bioanalysis, bioprocessing, chemistry, stability, histopathology, in vivo studies, and manufacturing. Customers love Sapio's platform because it is robust, scalable, and can quickly adapt to meet unique needs. The only true platform fully no-code/low-code configurable, enabling labs to easily adapt workflows and features without extensive vendor involvement. Robust integrations with laboratory instruments, ERP, and enterprise systems; supports APIs and webhook connectivity. Many solutions off the shelf. -
6
Labguru
BioData
Labguru is a secure, cloud-based Electronic Lab Notebook (ELN), LIMS and informatics platform which offers a complete solution for life science research and industry. It records and manages laboratory data and inventory, includes molecular biology tools and chemistry tools, enables automation of the lab, insight into lab data making labs run more efficiently. With Labguru, scientists can design experiments and workflows, capture structured and unstructured data, manage projects, and share their work. Customizable experiment templates, integration of protocols, SOPs, and other cutting-edge features help to increase data quality, streamline workflows and reduce costs. Labguru is available on desktops and mobile devices via the cloud. Labguru is part of Holtzbrinck Publishing Group and serves over 100,000 scientists worldwide from startups, universities, research institutes up to some of the largest pharma companies. -
7
LIMSey
LIMSey
LIMSey is a web-based software designed to help engineering and mechanical test labs manage their entire process within one system. Assign and schedule resources, track job progress, manage ever-changing priorities, generate custom test reports, support regulatory audits and accreditation, manage equipment, maintenance, calibrations, training records, and more. All features, updates, and support are always included with no additional modules to buy. We focus on continuous improvement and regularly meet with our existing customers to plan and discuss new features. This collaboration helps drive the development of LIMSey to solve more and more real world problems faced by test labs. Most of our new features come directly from customer requests/. We're also very familiar with ISO / IEC 17025 and would love to help with your initial accreditation or renewal. Call us today at 512-537-9323 for a demo or free trial and start managing your entire lab from one place. -
8
SciNote
SciNote
SciNote is a cloud-based electronic lab notebook (ELN) with built-in inventory, compliance, & team management tools. It is trusted by the FDA, USDA, European Commission, and 100K+ scientists in over 100 countries. Each premium plan comes with top-rated customer support, and a customer success manager who will work closely with you to ensure successful onboarding and implementation. SciNote provides a top-rated set of data management functionalities, such as inventory tracking & management, protocol & SOP management, compliance (CFR 21 part 11 & GxP), team management & collaboration, integrations and API, project management, safety & security of data and more. SciNote is based in Middleton, WI, USA, with offices in Europe. -
9
Scilligence ELN
Scilligence
Scilligence ELN is a unified informatics platform that supports R&D effort across all scientific branches focusing on small molecules, mRNA, ADCs, DEL, and more. Our ELN provides an elegant solution to macromolecule work by leveraging the most advanced HELM implementations. With its purposeful design the Scilligence ELN is a platform that will help your lab elevate internal and external collaborative processes. Major Features • Large selection of user-vetted experiment templates • Proprietary indexing capabilities enable structure, HELM, and biosequence queries • Seamless integration with registration, inventory, and assay data warehouse • Proprietary informatics engine enables advanced HELM functionality and enhanced stereochemistry • Auto-extract information from flat files via our Data Reader technology for efficient data capturing and processing -
10
LabCollector LIMS
AgileBio
LabCollector Lab Services Manager (LSM) is a cutting-edge network-based software solution that helps core facilities, laboratories, and biotechs. Simple and fully comprehensive, LabCollector LMS helps users manage a variety of useful day-to-day lab information. The solution comes with powerful modules, such as Strains & Cells Module, Plasmids Module, Sequences Module, Antibodies Module, Chemical Structures Module, Reagents & Supplies, Animals Module, Samples Module, Documents Module, Equipment Module, Address Book Module, and so much more.Starting Price: $2500.00/one-time/user -
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Xybion LIMS
Xybion
Xybion LIMS (formerly Labwise XD) is an all-inclusive LIMS, ELN, QMS, and DMS. Xybion LIMS drives lab workflows, instills consistency, improves data quality, and supports regulatory compliance with a complete laboratory management solution that connects with your operating systems with powerful laboratory information management and analytics. Xybion LIMS creates optimized workflows for the unique business needs of all regulated laboratories including research, diagnostics, quality control, stability studies, and more. -
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Ansys Cloud Direct
Ansys
Access Ansys Cloud Direct anywhere, anytime to obtain endless simulation capabilities compatible with most Ansys solvers. Engineering simulation has long been constrained by fixed computing resources available on a desktop or cluster. Ansys Cloud provides access to on-demand, cloud-based computing resources, including both interactive workstations and HPC clusters, for faster, high-fidelity results offering greater performance insight. Ansys Cloud increases simulation throughput by removing the hardware barrier. Ansys Cloud Direct is a scalable and cost-effective approach to HPC in the cloud. To leverage the combined benefits of cloud computing and best-in-class engineering simulation, Ansys partnered with Microsoft® Azure™ to create a secure cloud solution. Within Ansys Mechanical, Ansys Fluent, Ansys Electronics Desktop, Ansys SPEOS, Ansys Discovery, Ansys LS-Dyna, Ansys LST, Ansys CFX and Ansys Lumerical, you can easily access HPC in the cloud directly from the applications -
13
L7|ESP
L7 Informatics
L7 Enterprise Science Platform (L7|ESP®) is a unified platform that contextualizes data and eliminates business silos via process orchestration. It's a comprehensive solution that facilitates the digitalization of data and scientific processes in life sciences organizations. L7|ESP has native applications, including L7 LIMS, L7 Notebooks, L7 MES, L7 Scheduling, and more. It can integrate with existing third-party applications, lab instruments, and devices to capture all data in a single data model. It has a low-code/no-code workflow designer and hundreds of pre-built connectors to enable rapid time-to-value and end-to-end automation. By leveraging a single data model, L7|ESP enables advanced bioinformatics, AI, and ML to offer novel scientific and operational insights. L7|ESP addresses data and lab management needs in life sciences, particularly in: ● Research and Diagnostics ● Pharma and CDMO ● Clinical Sample Management Resource Center: l7informatics dot com/resource-center -
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Scispot
Scispot
Scispot powers life science labs with a unified LabOS™ platform, combining ELN, LIMS, SDMS, QMS, and AI in one configurable, no-code system. Built for CROs, Molecular Diagnostics, Pathology, Pharma QC, and Drug Discovery, Scispot streamlines sample management, inventory automation, and regulatory compliance. Connect with 200+ lab instruments and thousands of apps to eliminate data silos while maintaining FDA 21 CFR Part 11, GxP, GDPR, and HIPAA compliance. Scispot's AI tools transform experimental data into actionable insights, with flexible workflows that adapt as research evolves—without IT support. Trusted by 1000+ scientists globally, Scispot enables rapid deployment so teams focus on science, not administration. Accelerate discoveries, ensure compliance, and scale operations with a platform purpose-built for modern biotech innovation. -
15
Sapio ELN
Sapio Sciences
Sapio ELN is an electronic lab notebook that flexes to the needs of every scientific experiment by combining a built-in AI assistant, science-aware tools, no-code configurability, and powerful data integration and visualization into one unified platform. Its ELaiN chat assistant lets scientists create and configure experiments, manage consumables, integrate and query data, visualize results, optimize DNA sequences, and even generate custom code, all via natural-language conversation. The ELN includes an advanced molecular biology toolkit (CRISPR design, plasmid and compound design, PCR primer design, vector modification, genome browser), reusable experiment templates, free-form note taking, instrument integrations, real-time collaboration, and built-in statistical calculations. Science-aware searching lets users find structured and unstructured data, including substructure and similarity compound queries, and instantly generate interactive, scientific visualizations without SQL. -
16
Labfolder
Labfolder
Drag & Drop all file formats into your electronic notebook and have your results side by side with your experimental procedure. Access your data anywhere in the world and download it from any computer. Import, preview, and extract Word and Excel files in Labfolder’s ELN. Work on these documents inside Labfolder while always keeping a copy of the original file. View images inside your lab notebook and take advantage of a vast array of annotation tools to always highlight what you want. Your annotations are stored on a separate layer, guaranteeing that your original image is always preserved. Your content does not need to be static once you create it. Drag and drop different elements within your entry to rearrange the layout. Labfolder is a browser-based ELN software and therefore compatible with all operating systems and most popular browsers. Access your data anywhere in the world and always be up to date with the latest developments of your research. -
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Alchemy Cloud
Alchemy
Alchemy is an enterprise SaaS company helping to modernize the $1 trillion global specialty chemicals industry. Alchemy helps specialty chemicals companies accelerate their formula development and commercialization processes, be more responsive to customers, and grow top line revenue. With Alchemy's Chemistry Acceleration Software, customers increase lab capacity, accelerate chemistry innovation, and grow sales. From concept to chemistry, Alchemy accelerates product development and improves service delivery for chemicals and materials companies. Whether you’re working on fundamental R&D, new products or helping customers get the most from your current products, Alchemy accelerates your lab, sales and service processes so you can speed time to revenue on new product development, decrease lab cost per sale and improve customer responsiveness. Industry-specific software to accelerate chemistry development, sales and service. -
18
CDD Vault
Collaborative Drug Discovery
With CDD Vault, you can intuitively organize chemical structures and biological study data, and collaborate with internal or external partners through an easy to use web interface. Start your free trial and see first hand how easy it is to manage drug discovery data. Tailored for you Affordable Scales with your project team(s) Activity & Registration * Electronic Lab Notebook (ELN) * Visualization * Inventory * APIs * Secure Online Hosting -
19
Signals Notebook
Revvity Signals
Signals Notebook has a modern user interface like the ones on all your personal apps, the need for training is negligible. You will be up and running in no time. That’s part of the reason Signals Notebook is the electronic lab notebook of choice for companies as to whether it’s a team of 4-5 research scientists to the largest biotechs and pharmaceutical companies in the world. Flexibility and breadth to support wide range of workflows now and in the future — including both chemistry, biology, formulations, analytical sciences, and materials sciences. Over 1 million scientists at 4000 organizations count on Signals Notebook to help them streamline their workflows. Structured data capture with APIs and interfaces for integration with instruments, in-house systems, and databases. -
20
Arxspan
Arxspan
Arxspan's Electronic Lab Notebook is a fully integrated cloud platform for scientific data management that combines chemistry and biology data in one system. It is perfectly designed to enhance collaborative research across internal teams & external partners. Support for chemistry and biology experiments and workflows in single cloud ELN. Keyword, advanced, and chemical searching. Attachment and in-line editing for all Microsoft Office, image, and instrument files. Deployment in the private, secure Arxspan Cloud environment eliminates costly hardware acquisition, maintenance and IT overhead. Out of box integration with legacy electronic laboratory notebook systems. View and/or write sharing capabilities at notebook and project level. Configurable user role and permission hierarchies. Experiment signing and witnessing workflows. SAFE BioPharma compatibility for multi-factor capabilities. Support for validation of system and system updates. -
21
Dotmatics
Dotmatics
Dotmatics is the global leader in R&D scientific software that connects science, data, and decision-making. Combining a workflow and data platform with best-of-breed applications, we offer the first true end-to-end solutions for biology, chemistry, formulations, data management, flow cytometry, and more. Trusted by more than 2 million researchers from the world’s leading biopharma, chemicals and materials enterprises, and academic institutions, we are dedicated to working with the scientific community to help make the world a healthier, cleaner and safer place to live. Learn more about our platform and products, including GraphPad Prism, Geneious, SnapGene, Protein Metrics, LabArchives, and more. -
22
iVention Lab Execution System (iLES)
iVention
Create seamless data integration and world-class informatics management. iLES is a one-stop communication, documentation, storage and workflow hub for your whole organization, all in real time. iLES has the capabilities of LIMS (Lab Information System), ELN (Electronic Lab Notebook), SDMS (Scientific Data Management System), and DMS (Data Management System). But no matter which digital stage your lab is ready to embark on or which system your lab is ready to replace, iLES uses vendor-neutral technologies to help integrate your islands of data. You will only need to access one system, iLES, to take care of all your lab's needs and communications for all users. Rapid feature release and automated upgrades. Securely access information anywhere in the world using any device with Internet connection. Vendor-neutral technology helps to transform laboratories into tightly integrated paperless environments. -
23
IDBS E-WorkBook
IDBS
IDBS E-WorkBook is the world’s best-in-class informatics platform for scientific research and discovery. Its flexibility can meet the demands of your industry and those of various business units in your organization today, and can rapidly adapt and scale to meet whatever requirements you may have tomorrow. ELN, LIMS and other legacy software have played an important role in many research projects but their limitations hamper data visibility, obstructs collaboration which hinders further innovations and progress. Combining the very best functionalities of lab-based informatics E-WorkBook goes beyond traditional lab management software, providing cutting-edge data capture and analysis tools, job requesting and management, inventory management, and biology and chemistry functionality. E-WorkBook captures all the information scientists generate and stores it in the cloud. Any system or database used in a lab can be seamlessly ‘plugged in’ or integrated. -
24
E-Notebook
PerkinElmer
It’s time to make your organization and its scientists more productive with our industry-leading e-notebook, the ideal user-friendly solution for data capturing, archiving, sharing, and protecting intellectual property. With this powerful and intuitive tool, you can drive enhanced collaboration, innovation, and productivity across your organization. Our E-Notebook solution for research and development provides a common workflow that embodies industry best practices for data capture, archiving, and intellectual property while creating a shareable archive to drive collaboration and innovation. There are specialized capabilities for chemistry, biology, formulations, and analytical workflow management, making it the perfect enterprise-wide solution for your organization. With E-Notebook you can more effectively plan, perform, and document experiments to avoid duplication of work and to maximize knowledge gained from experiments. -
25
IDBS Polar
IDBS
Meet IDBS Polar, the world’s first BioPharma Lifecycle Management (BPLM) platform, eliminating repetitive manual tasks, allowing you to efficiently execute your processes while curating the data you need to accelerate time to market by tackling the biggest challenges in process design, optimization, scale-up, and technology transfer. Interactive data analytics applications, such as bioreactor comparison designed specifically for biopharma development scientists. IDBS Polar is a platform that securely manages drug progression in contexts of workflow, integration, and insight. Workflows designed to simplify the BioPharma Lifecycle with process-aware planning, design, and execution of end-to-end bioprocess and analytical unit operations. Integrations that bring meaning to your data. Rapid integration into your development ecosystem, enabling automation and curating a process-centric data backbone. -
26
BIOVIA Notebook
Dassault Systèmes
BIOVIA Notebook is a flexible and easy-to-use electronic lab notebook designed to streamline data capture, intellectual property protection, and information sharing for scientific organizations. It offers a high degree of flexibility for electronic data capture, accommodating both small to mid-size companies and large global enterprises. It features a flexible experiment editor that allows users to record experiments quickly and easily, working with text, images, documents, chemical structures, analytical data, and more. Its powerful search functionality enables users to easily store, search, and share entries from any location. BIOVIA Notebook includes built-in e-signatures and workflow reminders to ensure maximum IP protection and regulatory compliance. Access control is managed through versatile permissions based on project and group memberships, allowing configurations to range from open to locked-down as required. -
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BIOVIA ONE Lab
Dassault Systèmes
BIOVIA ONE Lab is a comprehensive laboratory informatics solution designed to streamline workflows, enhance collaboration, and accelerate research across various scientific domains. It provides a unified environment for managing all laboratory data and processes, enabling scientists to make better decisions faster. ONE Lab is leveraged by companies across multiple industries, including Life Sciences, Consumer Packaged Goods, Energy & Materials, and more. It can be deployed across Research, Development, and QA/QC, with the flexibility to meet the specific needs of scientists in each domain. It manages samples, experiments, data, inventory, equipment, and workflows, integrating with a wide range of laboratory instruments and software to connect existing systems and data seamlessly. ONE Lab removes artificial barriers between ELN, LIMS, LES, equipment integration, and inventory management by employing a single data model across all functional areas.
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