Best HPC Software in the USA
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Compare the Top HPC Software in the USA as of November 2025
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What is HPC Software in the USA?
High-Performance Computing (HPC) software are applications designed to maximize computational power, enabling complex and resource-intensive tasks to be executed efficiently. These programs optimize parallel processing, often leveraging supercomputers or distributed computing clusters to solve problems in fields like scientific research, engineering, and data analytics. HPC software includes components for workload management, data communication, and performance tuning, ensuring scalability and efficient resource utilization. Examples include simulation software, machine learning frameworks, and tools for weather modeling or molecular dynamics. By harnessing advanced algorithms and hardware, HPC software accelerates computation, reducing the time required for tasks that would otherwise take weeks or months on conventional systems. Compare and read user reviews of the best HPC software in the USA currently available using the table below. This list is updated regularly.
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1
UberCloud
Simr (formerly UberCloud)
Simr (formerly UberCloud) is a cutting-edge platform for Simulation Operations Automation (SimOps). It streamlines and automates complex simulation workflows, enhancing productivity and collaboration. Leveraging cloud-based infrastructure, Simr offers scalable, cost-effective solutions for industries like automotive, aerospace, and electronics. Trusted by leading global companies, Simr empowers engineers to innovate efficiently and effectively. Simr supports a variety of CFD, FEA and other CAE software including Ansys, COMSOL, Abaqus, CST, STAR-CCM+, MATLAB, Lumerical and more. Simr automates every major cloud including Microsoft Azure, Amazon AWS, and Google GCP. -
2
Samadii Multiphysics
Metariver Technology Co.,Ltd
Metariver Technology Co., Ltd. is developing innovative and creative computer-aided engineering (CAE) analysis S/W based on the latest HPC technology and S/W technology including CUDA technology. We will change the paradigm of CAE technology by applying particle-based CAE technology and high-speed computation technology using GPUs to CAE analysis software. Here is an introduction to our products. 1. Samadii-DEM (the discrete element method): works with the discrete element method and solid particles. 2. Samadii-SCIV (Statistical Contact In Vacuum): working with high vacuum system gas-flow simulation. Using Monte Carlo simulation. 3. Samadii-EM (Electromagnetics): For full-field interpretation 4. Samadii-Plasma: Plasma simulation for Analysis of ion and electron behavior in an electromagnetic field. 5. Vampire (Virtual Additive Manufacturing System): Specializes in transient heat transfer analysis. additive manufacturing and 3D printing simulation software -
3
Covalent
Agnostiq
Covalent’s serverless HPC architecture allows you to easily scale jobs from your laptop to your HPC/Cloud. Covalent is a Pythonic workflow tool for computational scientists, AI/ML software engineers, and anyone who needs to run experiments on limited or expensive computing resources including quantum computers, HPC clusters, GPU arrays, and cloud services. Covalent enables a researcher to run computation tasks on an advanced hardware platform – such as a quantum computer or serverless HPC cluster – using a single line of code. The latest release of Covalent includes two new feature sets and three major enhancements. True to its modular nature, Covalent now allows users to define custom pre- and post-hooks to electrons to facilitate various use cases from setting up remote environments (using DepsPip) to running custom functions.Starting Price: Free -
4
Qlustar
Qlustar
The ultimate full-stack solution for setting up, managing, and scaling clusters with ease, control, and performance. Qlustar empowers your HPC, AI, and storage environments with unmatched simplicity and robust capabilities. From bare-metal installation with the Qlustar installer to seamless cluster operations, Qlustar covers it all. Set up and manage your clusters with unmatched simplicity and efficiency. Designed to grow with your needs, handling even the most complex workloads effortlessly. Optimized for speed, reliability, and resource efficiency in demanding environments. Upgrade your OS or manage security patches without the need for reinstallations. Regular and reliable updates keep your clusters safe from vulnerabilities. Qlustar optimizes your computing power, delivering peak efficiency for high-performance computing environments. Our solution offers robust workload management, built-in high availability, and an intuitive interface for streamlined operations.Starting Price: Free -
5
TotalView
Perforce
TotalView debugging software provides the specialized tools you need to quickly debug, analyze, and scale high-performance computing (HPC) applications. This includes highly dynamic, parallel, and multicore applications that run on diverse hardware — from desktops to supercomputers. Improve HPC development efficiency, code quality, and time-to-market with TotalView’s powerful tools for faster fault isolation, improved memory optimization, and dynamic visualization. Simultaneously debug thousands of threads and processes. Purpose-built for multicore and parallel computing, TotalView delivers a set of tools providing unprecedented control over processes and thread execution, along with deep visibility into program states and data. -
6
PowerFLOW
Dassault Systèmes
By leveraging our unique, inherently transient Lattice Boltzmann-based physics PowerFLOW CFD solution performs simulations that accurately predict real world conditions. Using the PowerFLOW suite, engineers evaluate product performance early in the design process prior to any prototype being built — when the impact of change is most significant for design and budgets. PowerFLOW imports fully complex model geometry and accurately and efficiently performs aerodynamic, aeroacoustic and thermal management simulations. Automated domain discretization and turbulence modeling with wall treatment eliminates the need for manual volume meshing and boundary layer meshing. Confidently run PowerFLOW simulations using large number of compute cores on common High Performance Computing (HPC) platforms. -
7
HPE Pointnext
Hewlett Packard
This confluence put new demands on HPC storage as the input/output patterns of both workloads could not be more different. And it is happening right now. A recent study of the independent analyst firm Intersect360 found out that 63% of the HPC users today already are running machine learning programs. Hyperion Research forecasts that, at current course and speed, HPC storage spending in public sector organizations and enterprises will grow 57% faster than spending for HPC compute for the next three years. Seymour Cray once said, "Anyone can build a fast CPU. The trick is to build a fast system.” When it comes to HPC and AI, anyone can build fast file storage. The trick is to build a fast, but also cost-effective and scalable file storage system. We achieve this by embedding the leading parallel file systems into parallel storage products from HPE with cost effectiveness built in. -
8
ScaleCloud
ScaleMatrix
Data-intensive AI, IoT and HPC workloads requiring multiple parallel processes have always run best on expensive high-end processors or accelerators, such as Graphic Processing Units (GPU). Moreover, when running compute-intensive workloads on cloud-based solutions, businesses and research organizations have had to accept tradeoffs, many of which were problematic. For example, the age of processors and other hardware in cloud environments is often incompatible with the latest applications or high energy expenditure levels that cause concerns related to environmental values. In other cases, certain aspects of cloud solutions have simply been frustrating to deal with. This has limited flexibility for customized cloud environments to support business needs or trouble finding right-size billing models or support. -
9
The Nimbix Supercomputing Suite is a set of flexible and secure as-a-service high-performance computing (HPC) solutions. This as-a-service model for HPC, AI, and Quantum in the cloud provides customers with access to one of the broadest HPC and supercomputing portfolios, from hardware to bare metal-as-a-service to the democratization of advanced computing in the cloud across public and private data centers. Nimbix Supercomputing Suite allows you access to HyperHub Application Marketplace, our high-performance marketplace with over 1,000 applications and workflows. Leverage powerful dedicated BullSequana HPC servers as bare metal-as-a-service for the best of infrastructure and on-demand scalability, convenience, and agility. Federated supercomputing-as-a-service offers a unified service console to manage all compute zones and regions in a public or private HPC, AI, and supercomputing federation.
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10
Amazon EC2 G4 Instances
Amazon
Amazon EC2 G4 instances are optimized for machine learning inference and graphics-intensive applications. It offers a choice between NVIDIA T4 GPUs (G4dn) and AMD Radeon Pro V520 GPUs (G4ad). G4dn instances combine NVIDIA T4 GPUs with custom Intel Cascade Lake CPUs, providing a balance of compute, memory, and networking resources. These instances are ideal for deploying machine learning models, video transcoding, game streaming, and graphics rendering. G4ad instances, featuring AMD Radeon Pro V520 GPUs and 2nd-generation AMD EPYC processors, deliver cost-effective solutions for graphics workloads. Both G4dn and G4ad instances support Amazon Elastic Inference, allowing users to attach low-cost GPU-powered inference acceleration to Amazon EC2 and reduce deep learning inference costs. They are available in various sizes to accommodate different performance needs and are integrated with AWS services such as Amazon SageMaker, Amazon ECS, and Amazon EKS. -
11
QumulusAI
QumulusAI
QumulusAI delivers supercomputing without constraint, combining scalable HPC with grid-independent data centers to break bottlenecks and power the future of AI. QumulusAI is universalizing access to AI supercomputing, removing the constraints of legacy HPC and delivering the scalable, high-performance computing AI demands today. And tomorrow too. No virtualization overhead, no noisy neighbors, just dedicated, direct access to AI servers optimized with NVIDIA’s latest GPUs (H200) and Intel/AMD CPUs. QumulusAI offers HPC infrastructure uniquely configured around your specific workloads, instead of legacy providers’ one-size-fits-all approach. We collaborate with you through design, deployment, to ongoing optimization, adapting as your AI projects evolve, so you get exactly what you need at each step. We own the entire stack. That means better performance, greater control, and more predictable costs than with other providers who coordinate with third-party vendors.
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