Glutation transferaza
| Glutation transferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.5.1.18 | ||||||||
| CAS broj | 50812-37-8 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Glutation transferaza (EC 2.5.1.18, glutation S-transferaza, glutation S-alkiltransferaza, glutation S-ariltransferaza, S-(hidroksialkil)glutation lijaza, glutation S-aralkiltransferaza, glutation S-alkil transferaza, GST) je enzim sa sistematskim imenom RX:glutation R-transferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- RX + glutation HX + R-S-glutation
Ova grupa enzima ima široku specifičnost. R može da bude alifatična, aromatična ili heterociklična grupa; X može da bude sulfatna, nitrilna ili halidna grupa.
Reference
[уреди | уреди извор]- ^ Habig, W.H., Pabst, M.J. and Jakoby, W.B. (1974). „Glutathione S-transferases. The first enzymatic step in mercapturic acid formation”. J. Biol. Chem. 249: 7130—7139. PMID 4436300.
- ^ Jakoby, W.B. (1978). „The glutathione S-transferases: a group of multifunctional detoxification proteins”. Adv. Enzymol. Relat. Areas Mol. Biol. 46: 383—383. PMID 345769.
- ^ Jakoby, W.B. (1985). „Glutathione transferases: an overview”. Methods Enzymol. 113: 495—499. PMID 4088070.
- ^ Keen, J.H. & Jakoby, W.B. (1978). „Glutathione transferases. Catalysis of nucleophilic reactions of glutathione”. J. Biol. Chem. 253: 5654—5657. PMID 670218.
- ^ Sheehan, D., Meade, G., Foley, V.M. and Dowd, C.A. (2001). „Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily”. Biochem. J. 360: 1—16. PMID 11695986.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
[уреди | уреди извор]- Glutathione+transferase на US National Library of Medicine Medical Subject Headings (MeSH)