SUPEROXIDE DISMUTASE 1 AND 2 GENE POLYMORPHISM
IN TURKISH VITILIGO PATIENTS
Tuna A1, Ozturk G1, Gerceker TB1, Karaca E2,*, Onay H2, Guvenc SM2, Cogulu O2
*Corresponding Author: Emin Karaca, M.D., Associacte Professor, Department of Dermatology and Venerology, Faculty
of Medicine, Ege University, Kazım Dirik mah, Izmir, Turkey. Tel: +90-232-3903961-+90-532-2579285. Fax: +90-232-
3903971. E-mail: karacaemin@gmail.com
page: 67
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Abstract
Vitiligo is an acquired disease of unknown etiology.
Several theories have been proposed to understand the
pathogenesis. The role of oxidative stress has been getting
more important in recent years. One of the primary
antioxidant enzymes in vitiligo is the superoxide dismutase
(SOD). The aim of this study is to investigate the polymorphisms
of the SOD1 and SOD2 in Turkish vitiligo patients.
One hundred one vitiligo patients and 99 healthy controls
without family history of vitiligo were included into the
study. The SOD1 35 A/C and SOD2 A16V (C/T) polymorphisms
were analyzed by polymerase chain reactionrestriction
fragment length polymorphim (PCR-RFLP).
Viti-ligo patients and control group of SOD1 35 A/C and
SOD2 A16V (C/T) polymorphism allele frequencies were
compared by using χ2 tests. The distribution of the SOD1
35 AA and AC genotypes were similar in vitiligo patients
and control group. When the patient and the control groups
were compared for the SOD2 Ala9Val (C/T) polymorphism,
a significant difference was determined for the
distribution of the genotypes [p = 0.047, odds ratio (OR) =
2.075, 95% confidence interval (95% CI) = 1.008-4.272].
The relative risk for development of vitiligo was found as
a 2-fold increase in the TT genotype. The increase of TT
homozygosity in the vitiligo cases creates the problem on
the transfer of the enzyme to the mitochondria and thus, the
SODs antioxidant effect may decrease in vitiligo but the
polymorphism was not determined in all patients, so this
study needs to be substantiated by other studies containing
a higher number of patients.
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