Tosposertib (TU2218) is a highly potent, oral dual inhibitor designed to block the signaling pathways of transforming growth factor-beta (TGF>-β) and vascular endothelial growth factor (VEGF), two critical mediators of tumor growth and metastasis.
) Dual targeting of TGF>-β and EGFR with ficerafusp alfa shows superior antitumor activity over cetuximab in KRAS/BRAF wild-type MSS colorectal cancer cell lines ... Dual targeting of EGFR and TGF-β with ficerafusp alfa showed improved ... TGF-β1 in pg/mL.