Tosposertib (TU2218) is a highly potent, oral dual inhibitor designed to block the signaling pathways of transforming growth factor-beta (TGF-β) and vascular endothelial growth factor (VEGF), two critical mediators of tumor growth and metastasis.
Preclinical results support 6-month dosing, demonstrating VLTR-559’s substantially longer ocular half-life, with high drug concentrations retained in the retina compared to current anti-VEGF standard of care ... .