After his close friend, an affable and absent minded college professor (Stanley Ridges) is critically injured when a gangster runs him down, Karloff does what any other doctor would do – he transplants the gangster's brain into Ridges' head. Incredibly, Karloff manages to do this by himself, with no one at the hospital knowing about it. What's more, he doesn't need prior authorization from Ridges' health insurance company. In fact, Karloff does such a great job, there are no scars on Ridges, and he also maintains his full head of hair.
It seems the gangster has hidden 500 grand somewhere, so Karloff figures maybe he can coax the location out of Ridges, who is starting to act strangely. In short order, the gangster brain takes over, and Ridges (now looking about 30 years younger) goes on a killing spree, exacting revenge on his former gang. On occasion, he returns to his professor self. How will this all end? If you can ignore the stupidity involved, this is one of the most entertaining of the Universal horror flicks. Beautifully paced, never dull, the film benefits from a great Hans J. Salter score, with familiar themes he used over and over in multiple films. Karloff is fine as the doctor. But the real star is Ridges, who is outstanding in a dual role. Anne Nagel, as the gangster's girlfriend, is gorgeous. Murray Alper is very amusing as a confused bellboy. However, Bela Lugosi, billed second, is woefully miscast as one of the gangsters.