After a nasty motorcycle accident, a young couple, Hart (Frank Moore) and Rose (porn star Marilyn Chambers), are taken to a nearby plastic surgery clinic, where Rose undergoes a revolutionary skin grafting technique that results in the growth of a bloodsucking tumour. Driven by the lust for plasma, Rose flees the clinic and embarks on a series of attacks which leave her victims alive, but infected with a strain of rabies that causes them to react in a violent manner. As the disease rapidly turns into a city-wide epidemic and martial law is imposed, Hart attempts to locate his missing girlfriend, unaware that she is the carrier of the disease.
With crisper cinematography and more confident direction from David Cronenberg, Rabid is a technically superior effort to his 1975 film Shivers, but doesn't manage to be as satisfying an experience thanks to a script that becomes a tad too repetitive at times, strays a little to close to George Romero's The Crazies (1973) for comfort, and perhaps most importantly, fails to answer burning questions about the nature of Rose's condition: the needle tipped, phallic mutation, which emerges from a sphincter-like orifice from under Rose's arm, is as grotesque and unsettling as anything Cronenberg has conjured up since, but it's existence is never adequately explained, most likely because no amount of in-depth exposition could ever be convincing enough.
On a more positive note, Chambers does reasonably well in her first non-porn lead role, there are some genuinely nasty moments for which makeup guy Joe Blasco provides some pretty decent effects work (I particularly enjoyed the 'finger snipping' moment, and the impressive use of a pneumatic drill by one of the infected), and Cronenberg occasionally ditches his sober approach for the odd spot of delightfully twisted humour, such as the scene in which a mall Santa Claus gets accidentally machine-gunned by a trigger happy cop (well, I found it funny!).
Whilst Rabid certainly doesn't qualify as essential Cronenberg, it is still worth a look if you're a fan of the man's work and merits a reasonable 6.5 out of 10 from this viewer (generously rounded up to 7 for IMDb).