Killface is an albino supervillain with plans to blast the earth into the sun with a weapon called "The Annhilatrix". Xander Crews is a chauvinistic, idiotic playboy leading a double life as a billionaire tycoon and a superhero "Awesome-X" with an army of armoured soldiers called "The Xtacles". Killface was once referred to as his "arch nemesis and secret buddy." Crews must stop his plans as they both deal with their personal issues and side characters in and around 'The Town', and struggle to become better businessmen.
That's as close as I can get to describing the plot, since the way the show is presented needs to be seen to be believed. The humour is extremely random and demented, often gleefully obscene and outrageously violent. Characters are often killed without any warning, and the plot lines and dialogue are all very stream-of-consciousness. The show is so knee-slappingly funny and endlessly quotable that it will imprint itself on your mind. Soon "Kakow", "Boosh" and "We can never go back to Arizona!" will become part of your regular vocabulary.
Almost every side character is awesomely hilarious. There's Mr. Ford, the double-entendre spewing judge, Ronnie the perverted Xtacle, Killface's gay (?) son Simon, Crew's girlfriend Grace Ryan who he treats like dirt and is also arch-villainess 'Ant-agony', some meth-addicted hooker, a lesbian wannabe assassin, a half-man/half-crab hybrid, a giant ant baby, and a giant ant baby machete squad. Come to think of it, Frisky Dingo is probably not for the easily offended or the pretentious...
This show also features what is probably that greatest character in Adult Swim history: Wendell. A former agent of the department of labour, turned psychopathic killing machine, this guy is disgusting, weird and a total ass to everyone he meets, including his best friend who he framed for murder and then tried to have sex with his wife. This guy needs his own show big time.
Unfortunately only two seasons of this series were made, and it ends with a big cliffhanger. The studio had financial issues as I understand. These two seasons though are an unparallelled work of comedy genius. That is, if you don't mind it being completely absurd and filled to the brim with epic, epic penis jokes. Mastah cylindahhhh!! Don't look over here at what I'm doing! You point at it! You celebrate yourself!!