I have not played any of the Resident Evil games, but am a fan of the movie series.
This movie apparently takes place in the game universe. I had purchased the first Resident Evil animation, but have not watched it in a while.
This movie stands quite well on its own. The plot is fairly straight forward. Mr cool guy spy had been ordered away from his vacation to check out a problem regarding prisoners of war in a war torn former soviet country. It turns out they were turned into BOWs (Bio Organic Weapons). These are basically humans that have been mutated by a weaponized virus into deadly creatures controlled by whoever has been infected with the master form of the virus.
The country is undergoing a revolution, and the rebels have resorted to using the BOWs against the army. Our hero tries to survive and fight until he can figure out who's controlling the BOWs, and discovers the rebels are not the only ones with BOWs, and there is in fact a much deadlier version right under his very nose.
Action packed all the way through. The animation is better than the first animated movie and the story and acting are great. I enjoyed every minute of it, and I think animation, horror and/or zombie fans will enjoy it too.