Jesse Helms nació el 18 de octubre de 1921 en Carolina del Norte, EE.UU.. Estuvo casado con Dorothy Jane Coble. Murió el 4 de julio de 2008 en Raleigh, Carolina del Norte, EE.UU..
Both of his parents, both of his grandfathers, four of his
great-grandparents, five of his great-great-grandparents, and seven of
his great-great-great-grandparents bore the surname Helms.