Simply put, Run Leia Run is essentially a palette swap of Lola Rennt with Star Wars characters, scenery, and basic references. The plot and basically anything important in the movie is a Lola Rennt reference.
Like others have indicated, your enjoyment of the movie will be drastically reduced if you have not seen Lola Rennt before. I will go as far as to say that you will probably not get the movie at all, or at least, you won't get it beyond a very superficial level, if you have not watched Lola Rennt before. It's not good enough to just know the general plot of Lola Rennt, because Run Leia Run is pretty much one big fifteen-minute long Lola Rennt reference.
On the other hand, if you know the basic plot and main characters of the Star Wars movies, as well as a few more in-depth details about The Empire Strikes Back, you can actually get away with not having seen any of the Star Wars movies to enjoy this. A few things might go over your head, but not too much.
With all that said, if you are a fan of both movies, especially Lola Rennt, and you can set aside any reservations about low production quality, you will love this movie and just fall over laughing. The first time I learned of this movie, I repeated it five times in one sitting. In short, as much as I think Star Wars fans who happen to enjoy Lola Rennt will like this, I think Lola Rennt fans who happen to enjoy Star Wars will absolutely adore this movie.