The first time I HEARD of Vampire the Masquerade:Bloodlines was while searching for a new game to play after Neverwinter Nights 2. I watched Gopher's Let's play of Vampire the Masquerade:Bloodlines and after seeing the first (2) episodes, I stopped watching because I said I HAVE TO PLAY THIS!
This game has the most creative NPC (Non Player Characters) that interact with you an a way that is authentic, organic and very creative. The back story and Lore of World of Darkness by White Wolf in which Vampire the Masquerade:Bloodlines takes place in is one of treachery, plots within plots and the never-ending hunger (Called "The Beast") to feed on blood.
You have different choices that you can make, which have a DIRECT impact on your progression and interactions in the game.
You have the choice of playing from one of (8) clans as a Male or Female and each clan has their own individual powers, motivations, horrors and quests.
I started of playing the INCREDIBLE Clan Malkavian and had NUMEROUS humorous moments from the confusion on the individual faces because of the insanity that runs in this clans and their dialog choices.
I cannot recommend this game enough to anyone that's wants to experience a TRULY unique RPG video game.
Be sure to obtain and install the Official patch, found here: http://planet-vampire.net2
and then the Unofficial Patch, found here: http://www.patches-scrolls.de/patch
and Enjoy!!