As usual in anything Resident Evil, we've got villains that are so cartoonishly evil as their plans and motives are ridiculous. Every single faction in the movie is a carbon copy of Umbrella Corp. The movie is supposed to occur in the Eastern Slav Republic, so everyone speaks flawless English, even among them, but with a Slavic accent. The monsters suck. Bullets and other projectiles are small, fast-moving, autonomous plot devices that cause variable damage depending on the importance of the character their hit. In some cases, hundreds of bullets that go towards a specific target disappear midair and let him/her/it get away. In other cases, a monster that survived constant rifle fire at short range several times unharmed is killed by a single 9mm bullet.
The CGI is bad. The voice acting is bad. The lip-syncing is even worse.
The pro-American propaganda is pathetic, obvious, and omnipresent throughout the movie.
There is no script.
It's as if the director of this movie took Shoot 'em up, removed the sarcasm, replaced the hitmans with monsters and the actors with poor CGI models.
All that said, if you've seen every other umbrella-related thing, if you've played the games, and it's a gray Sunday afternoon and you really have nothing better to do, shut down your brain, and the action will be enjoyable.