Ōoku: Los aposentos privados

I'm a sucker for well-made alternate histories. This one makes the grade.

It's the Edo period in Japan. A mysterious plague decimates the male population. Women take over running the country. The plague's impact extends to the Shogun's household where there now is a male harem-the Ooku of the title-in attendance to the female Shogun. Palace intrigue ensues.

Based on just this outline you might think this was going to be just another harem-heavy comedy with fan service, adolescent jokes, and stale rom-com situations.

You would be mistaken. This series is actually an extended and sophisticated exploration of a range of serious themes such as gender identity, role reversal, sexual politics, and economic discrimination. If you like serious themes uniquely addressed, you should check this one out.