Hang on to your psychoanalysis, Ladies and Gentlemen...a young Brian De Palma has brought us a fine mindf*ck that is in good company with "Psycho," "The Tenant," and even "Fight Club." "Sisters" is a brain-sizzling thriller that probes the relationship between separated Siamese twins Danielle and Dominique (Margot Kidder) in a maniacally unsettling way. Danielle is a successful actress/model; Dominique is a raving lunatic who becomes violent when sexually aroused. When Dominique murders Danielle's boyfriend, reporter Grace Collier (Jennifer Salt) takes matters into her own hands after the police refuse to help. Meanwhile, Danielle's ex-husband Emil (John Waters doppleganger William Finley) runs a local psych ward. And Charles Durning plays a detective tracking the progress of a particularly heavy couch. De Palma weaves his character interactions seamlessly, employing the types of technical tricks that would be used more superficially in his later works (the use of split-screen to show action from two separate viewpoints, for instance), in addition to some of the trippiest black-and-white imagery this side of "Eraserhead." "Sisters" is an effective, highly influential work that holds up incredibly well today...just make sure you have a refill on your pills before watching it.