D.O.A has a good premise, borrowed from a 1950 film of the same name and a 1969 film entitled Color Me Dead. But beyond the premise it fails to develop into anything worthwhile. The script mistakes ludicrousness for cleverness; the directors peculiarly seem to think they're making a pop video rather than a film; and Dennis Quaid puts on a weird grin and raises his eyebrows maniacally as if he's auditioning as a Jack Nicholson impersonator. It's good for a laugh but, since that wasn't the original intention, it's hard to rate this as a worthwhile film.
English lecturer Dexter Cornell (Quaid) is a bitter, bored shell of a man. Formerly a great author, he never recovered from the critical failure of his fourth and final novel and vowed never to write again. Without the drive of writing to fill his life, he gave up on everything else too, including his marriage and his dedication to the job. When pupil Nick Lang (Rob Knepper) apparently commits suicide after handing in an assignment, Cornell hits the booze to get over the shock. But soon thereafter, he learns that he has drunk a slow-acting poison, and that within 48 hours he will be dead. So close to death, he finally finds a renewed purpose in being alive.... as, aided by student Sydney Fuller (Meg Ryan), he desperately attempts to solve his own "murder".
It's such a good idea that one can hardly imagine how it could fail. But it does. It really, really does fail in a big way. All the pointlessly fancy camera angles, all the inappropriate musical scoring, and especially the jaw-droppingly stupid solution to the mystery, conspire to ruin the film. D.O.A stands for "Dead On Arrival", and that's the perfect adjectival phrase for the entire film. Some day, this wonderful idea for a film might be used once again to better effect, but for now you'd be best advised to stick with the 1950 version.