For most of the first episode of this series I was thinking it would be fairly worthless. The main character, Shu, is annoying and not too bright, and I actually fast forwarded through about 15 minutes of the show just to see if anything would ever happen.
This opener, however, is just a brief taste of the life Shu will be leaving behind. Once he is transported to a disturbing other world (it is never explained how he gets there or where there actually is) the show takes on a completely different tone. It is, in fact, a horrific study of the consequences of war that contains murder, kidnapping, pedophiliac rape, child soldiers and mass murder.
The show has a very clear perspective: the people who wage war are evil, insane or dupes, and are sometimes all three. But while the series is incredibly grim, it does insist that a few good people can make a difference.
While the series has some typical anime elements, including weird technology, mystic powers and a heroic, headstrong boy, episodes are true to the human experience, with characters acting pretty much as one would expect. Fairly uncompromising, horrible things happen with great frequency, and for the most part, nothing can be done.
I think it would be pretty easy to find huge plot holes and inconsistencies. But the show doesn't really care about that, never even bothering to explain who or what Lala Rue is. All that matters is, war is very very bad, and peace cannot be won through war.