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The Opening Day sequence was filmed on September 4, 2004 with Stephen King throwing out the first pitch; the Red Sox lost that game, ending a 10-game winning streak and King was blamed for it in the Boston Globe.

Right before the scene where Lindsay gets hit with the ball, the legend on the screen says it's July. The ball Miguel Tejada of the Orioles hits into the stands, which hits Lindsay, is thrown by Mike Myers of the Red Sox. Mike Myers wasn't picked up by the Red Sox until August 6, 2004.

Following the credits, there is a short home-video-like clip of 4 children cheering on the Red Sox.

The DVD editon of the film dubbed the "Cursed Reversed Edition for Boston Red Sox fans" by Fox contains the alternate ending of the film that was actually shot during the 2004 playoffs and World Series. In the original ending of the film scripted by Lowell Ganz and Babaloo Mandel, "The Curse of the Bambino" dubbed by die hard Red Sox fans would have continued "if" the Yankees had beaten them in the playoffs. The Red Sox, who were down by three games, had come back and beaten the Yankees which was the first time a pro-sports team had ever come back from such a defeat and eventually won the World Series, sweeping the St.Louis Cardinals. The moment that it had happened, Drew Barrymore and Jimmy Fallon in character, ran onto the field and celebrated with the team. This ending was edited in the film as a montage with narration by actor Jack Kehler.

Edited into Fever Pitch: Red Sox Alternate Ending (2005)